About the Working Group
Invasive fungal infections are an increasing threat for immunocompromised individuals and associated with devastating morbidity and mortality. Clinicians and Researchers at UCSD have come together and founded a multidisciplinary working group (Clinical and Translational Fungal Research - Working Group). The CTFR-WG is dedicated to advancing the understanding, diagnostics and management of invasive fungal infections. In 2018, the working group completed two studies on point-of-care diagnosis of invasive aspergillosis, and on impact of combination antifungal therapy on survival in rare mold infections, and was very active in disseminating their research findings in a total of 8 Pub Med listed publications.
Members
 Martin Hoenigl, PhD
Assistant Professor;
President of the European
Confederation of Medical
Mycology, FECMM
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|  Jeffrey Jenks, MD, MPH
Assistant Professor
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|  Nancy Law, DO
Assistant Professor
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| 
Stephen Rawlings, MD
ID Fellow
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|
 Randy Taplitz, MD
Professor
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|
Sharon Reed, MD
Professor
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|
Sanjay Mehta, MD
Assistant Professor
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|
Cathy Logan, MD
|
Ongoing Projects
- Aspergillus and other Rare Mold Infections at UC San Diego Health (IRB #181119; PI Jenks)
- Novel Diagnostic Approaches for Invasive Pulmonary Aspergillosis (IRB #171104; PI Hoenigl)
- FungiScope Global Emerging Fungal Infections registry (IRB #171105; PI Hoenigl)
Clinical Trials
- SCY-078-206: Study to Evaluate the Safety and Efficacy of the Combination Therapy of Ibrexafungerp
(SCY-078) With Voriconazole in Patients With Invasive Pulmonary Aspergillosis (SCYNERGIA)
Publications
- Jenks JD, Mehta SR, Taplitz R, Aslam S, Reed SL, Hoenigl M. Point-of-care
diagnosis of invasive aspergillosis in non-neutropenic patients: Aspergillus
Galactomannan Lateral Flow Assay versus Aspergillus-specific Lateral Flow Device
test in bronchoalveolar lavage. Mycoses. 2018 Dec 18. doi: 10.1111/myc.12881.
[Epub ahead of print] PubMed
PMID: 30565352.
- Jenks JD, Salzer HJF, Hoenigl M. Improving the rates of Aspergillus detection:
an update on current diagnostic strategies. Expert Rev Anti Infect Ther. 2019
Jan;17(1):39-50. doi: 10.1080/14787210.2018.1558054. Epub 2018 Dec 17. PubMed
PMID: 30556438.
- Jenks JD, Mehta SR, Taplitz R, Law N, Reed SL, Hoenigl M. Bronchoalveolar
lavage Aspergillus Galactomannan lateral flow assay versus Aspergillus-specific
lateral flow device test for diagnosis of invasive pulmonary Aspergillosis in
patients with hematological malignancies. J Infect. 2018 Nov 2. pii:
S0163-4453(18)30319-0. doi: 10.1016/j.jinf.2018.10.014. [Epub ahead of print]
PubMed
PMID: 30391632.
- Jenks JD, Hoenigl M. Treatment of Aspergillosis. J Fungi (Basel). 2018 Aug
19;4(3). pii: E98. doi: 10.3390/jof4030098. Review. PubMed PMID: 30126229; PubMed
Central
PMCID: PMC6162797.
- Jenks JD, Reed SL, Seidel D, Koehler P, Cornely OA, Mehta SR, Hoenigl M. Rare
mould infections caused by Mucorales, Lomentospora prolificans and Fusarium, in
San Diego, CA: the role of antifungal combination therapy. Int J Antimicrob
Agents. 2018 Nov;52(5):706-712. doi: 10.1016/j.ijantimicag.2018.08.005. Epub 2018
Aug 9. PubMed PMID: 30099056; PubMed Central
PMCID: PMC6231988.
- Jenks JD, Salzer HJ, Prattes J, Krause R, Buchheidt D, Hoenigl M. Spotlight on
isavuconazole in the treatment of invasive aspergillosis and mucormycosis:
design, development, and place in therapy. Drug Des Devel Ther. 2018 Apr
30;12:1033-1044. doi: 10.2147/DDDT.S145545. eCollection 2018. Review. PubMed
PMID: 29750016; PubMed Central
PMCID: PMC5933337.
- Jenks JD, Mehta SR, Hoenigl M. Broad spectrum triazoles for invasive mould infections
in adults: Which drug and when? Med Mycol. 2019 Apr 1; 57 (Supplement_2):S168-S178.
doi: 10.1093/mmy/myy052.
PMID: 30816967
- Hoenigl M. Fungal Translocation: A driving force behind the Occurrence of non-AIDS Events?
Clin Infect Dis. 2019 Mar 12; pii: ciz215. doi: 10.1093/cid/ciz215.
PMID: 30861074
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