Clinical and Translational Fungal Research - Working Group (CTFR-WG)

About the Working Group

Invasive fungal infections are an increasing threat for immunocompromised individuals and associated with devastating morbidity and mortality. Clinicians and Researchers at UCSD have come together and founded a multidisciplinary working group (Clinical and Translational Fungal Research - Working Group). The CTFR-WG is dedicated to advancing the understanding, diagnostics and management of invasive fungal infections. In 2018, the working group completed two studies on point-of-care diagnosis of invasive aspergillosis, and on impact of combination antifungal therapy on survival in rare mold infections, and was very active in disseminating their research findings in a total of 8 Pub Med listed publications. 

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Members

Martin Hoenigl, MD
Assistant Professor
President of the European
Confederation of Medical
Mycology, FECMM
UCSD Profile
Jeffrey Jenks, MD, MPH
Assistant Professor
UCSD Profile
Nancy Law, DO
Assistant Professor
UCSD Profile

Stephen Rawlings, MD
ID Fellow
UCSD Profile

Randy Taplitz, MD
Professor
UCSD Profile


Sharon Reed, MD
 Professor
 UCSD Profile


 Sanjay Mehta, MD
 Assistant Professor
 UCSD Profile


Cathy Logan, MD
Assistant Professor
UCSD Profile



Ongoing Projects
  • Aspergillus and other Rare Mold Infections at UC San Diego Health (IRB #181119; PI Jenks)
  • Novel Diagnostic Approaches for Invasive Pulmonary Aspergillosis (IRB #171104; PI Hoenigl)
  • FungiScope Global Emerging Fungal Infections registry (IRB #171105; PI Hoenigl)

Clinical Trials

  • SCY-078-206: Study to Evaluate the Safety and Efficacy of the Combination Therapy of Ibrexafungerp
    (SCY-078) With Voriconazole in Patients With Invasive Pulmonary Aspergillosis (SCYNERGIA)

Publications

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  1. Jenks JD, Mehta SR, Taplitz R, Aslam S, Reed SL, Hoenigl M. Point-of-care
    diagnosis of invasive aspergillosis in non-neutropenic patients: Aspergillus
    Galactomannan Lateral Flow Assay versus Aspergillus-specific Lateral Flow Device
    test in bronchoalveolar lavage. Mycoses. 2018 Dec 18. doi: 10.1111/myc.12881.
    [Epub ahead of print] PubMed PMID: 30565352.
  2. Jenks JD, Salzer HJF, Hoenigl M. Improving the rates of Aspergillus detection:
    an update on current diagnostic strategies. Expert Rev Anti Infect Ther. 2019
    Jan;17(1):39-50. doi: 10.1080/14787210.2018.1558054. Epub 2018 Dec 17. PubMed
    PMID: 30556438.
  3. Jenks JD, Mehta SR, Taplitz R, Law N, Reed SL, Hoenigl M. Bronchoalveolar
    lavage Aspergillus Galactomannan lateral flow assay versus Aspergillus-specific
    lateral flow device test for diagnosis of invasive pulmonary Aspergillosis in
    patients with hematological malignancies. J Infect. 2018 Nov 2. pii:
    S0163-4453(18)30319-0. doi: 10.1016/j.jinf.2018.10.014. [Epub ahead of print]
    PubMed PMID: 30391632.
  4. Jenks JD, Hoenigl M. Treatment of Aspergillosis. J Fungi (Basel). 2018 Aug
    19;4(3). pii: E98. doi: 10.3390/jof4030098. Review. PubMed PMID: 30126229; PubMed
    Central PMCID: PMC6162797.
  5. Jenks JD, Reed SL, Seidel D, Koehler P, Cornely OA, Mehta SR, Hoenigl M. Rare
    mould infections caused by Mucorales, Lomentospora prolificans and Fusarium, in
    San Diego, CA: the role of antifungal combination therapy. Int J Antimicrob
    Agents. 2018 Nov;52(5):706-712. doi: 10.1016/j.ijantimicag.2018.08.005. Epub 2018
    Aug 9. PubMed PMID: 30099056; PubMed Central PMCID: PMC6231988.
  6. Denning DW, Page ID, Chakaya J, Jabeen K, Jude CM, Cornet M, Alastruey-Izquierdo A, Bongomin F, Bowyer P, Chakrabarti A, Gago S, Guto J, Hochhegger B, Hoenigl M, Irfan M, Irurhe N, Izumikawa K, Kirenga B, Mnaduku V, Moazam S, Oladele RO, Richardson MD, Tudela JLR, Rozaliyani A, Salzer HJF, Sawyer R, Simukulwa NF, Skrahina A, Sriruttan C, Setianingrum F, Wilopo BAP, Cole DC, Getahun H. Case Definition of Chronic Pulmonary Aspergillosis in Resource-Constrained Settings. Emerg Infect Dis. 2018 Aug;24(8). doi: 10.3201/eid2408.171312. PMCID: PMC6056117.
  7. Jenks JD, Salzer HJ, Prattes J, Krause R, Buchheidt D, Hoenigl M. Spotlight on
    isavuconazole in the treatment of invasive aspergillosis and mucormycosis:
    design, development, and place in therapy. Drug Des Devel Ther. 2018 Apr
    30;12:1033-1044. doi: 10.2147/DDDT.S145545. eCollection 2018. Review. PubMed
    PMID: 29750016; PubMed Central PMCID: PMC5933337.
  8. Hoenigl M, Gangneux JP, Segal E, Alanio A, Chakrabarti A, Chen SC, Govender N, Hagen F, Klimko N, Meis JF, Pasqualotto AC, Seidel D, Walsh TJ, Lagrou K, Lass-Florl C, Cornely OA, European Confederation of Medical Mycology (ECMM). Global guidelines and initiatives from the European Confederation of Medical Mycology to improve patient care and research worldwide: New leadership is about working together. Mycoses. 2018 Nov;61(11):885-894. doi: 10.1111/myc.12836. PMID: 30086186.
  9. Oladele RO, Osaigbovo II, Ayanlowo OO, Otu AA, Hoenigl M, Cornely OA, Chakrabarti A, Denning DW. The role of medical mycology societies in combatting invasive fungal infections in low- and middle-income countries: A Nigerian model. Mycoses. 2019 Jan;62(1):16-21. doi: 10.1111/myc.12845. PMID: 30184285.
  10. Hoenigl M. Fungal Translocation: A driving force behind the Occurrence of non-AIDS Events? 
    Clin Infect Dis. 2019 Mar 12; pii: ciz215. doi: 10.1093/cid/ciz215. PMID: 30861074
  11. Jenks JD, Mehta SR, Hoenigl M. Broad spectrum triazoles for invasive mould infections 
    in adults: Which drug and when? Med Mycol. 2019 Apr 1; 57 (Supplement_2):S168-S178. 
    doi: 10.1093/mmy/myy052. PMID: 30816967
  12. Bassetti M, Scudeller L, Giacobbe DR, Lamoth F, Righi E, Zuccaro V, Grecchi C, Rebuffi C, Akova M, Alastruey-Izquierdo A, Arikan-Akdagli S, Azoulay E, Blot SI, Cornely OA, Lass-Florl C, Koehler P, Cuenca-Estrella M, de Lange DW, De Rosa FG, De Waele JJ, Dimopoulos G, Garnacho-Montero J, HoeniglM, Kanj SS, Maertens J, Martin-Loeches I, Muñoz P, Kullberg BJ, Agvald-Ohman C, Poulakou G, Rello J, Sanguinetti M, Taccone FS, Timsit JF, Torres A, Vazquez JA, Calandra T; from the Study Group for Infections in Critically Ill Patients (ESGCIP) and the Fungal infection Study Group (EFISG) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID); European Society of Intensive Care Medicine (ESICM); European Confederation of Medical Mycology (ECMM); Mycoses Study Group Education and Research Consortium (MSGERC). Developing definitions for invasive fungal diseases in critically ill adult patients in intensive care units. Protocol of the FUNgal infections Definitions in ICU patients (FUNDICU) project. Mycoses. 2019 Apr;62(4):310-319. doi: 10.1111/myc.12869. PMID: 30426598.
  13. Aslam S, Rotstein C, AST Infectious Disease Community of Practice. Candida infections in solid organ transplantation: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clin Transplant. 2019 Jun 2:e13623. doi: 10.1111/ctr.13623. [Epub ahead of print] PMID: 31155770.
  14. Koehler P, Arendrup MC, Arikan-Akdagli S, Bassetti M, Bretagne S, Klingspor L, Lagrou K, Meis JF, Rautemma-Richardson R, Schelenz S, Hamprecht A, Koehler FC, Kurzai O, Salmanton-Garcia J, Vehreschild JJ, Alanio A, Alastruey-Izqierdo A, Arsic Arsenijevic V, Gangneux JP, Gow NAR, Hadina S, Hamal P, Johnson E, Klimko N, Lass-Florl C, Mares M, Ozenci V, Papp T, Roilides E, Sabino R, Segal E, Talento AF, Tortorano AM, Verweij PE, Hoenigl M, Cornely OA; European Confederation of Medical Mycology (ECMM). ECMM CandiReg-A ready to use platform for outbreaks and epidemiological studies. Mycoses. 2019 Jul 4. doi: 10.1111/myc.12963. PMID: 31271702.
  15. Rawlings SA, Heldt S, Prattes J, Eigl S, Jenks JD, Flick H, Rabensteiner J, Pruller F, Wolfler A, Neumeister P, Strohmaier H, Krause R, Hoenigl M. Using Interleukin 6 and 8 in Blood and Bronchoalveolar Lavage Fluid to Predict Survival in Hematological Malignancy Patients With Suspected Pulmonary Mold Infection. Front Immunol. 2019 Aug 2;10:1798. doi: 10.3389/fimmu.2019.01798. PMCID: PMC6687868.
  16. Salmanton-Garcia J, Seidel D, Koehler P, Mellinghoff SC, Herbrecht R, Klimko N, Racil Z, Falces-Romero I, Ingram P, Benitez-Peñuela MA, Rodriguez JY, Desoubeaux G, Barac A, Garcia-Vidal C, Hoenigl M, Mehta SR, Cheng MP, Klyasova G, Heinz WJ, Igbal N, Krause R, Ostermann H, Penack O, Schalk E, Sheppard DC, Willinger B, Wisplinghoff H, Vehreschild JJ, Cornely OA, Vehreschild MJGT; FungiScope ECMM/ISHAM Working Group. Matched-paired analysis of patients treated for invasive mucormycosis: standard treatment versus posaconazole new formulations (MoveOn). J Antimicrob Chemother. 2019 Aug 8. pii: dkz344. doi: 10.1093/jac/dkz344. PMID: 31393591.
  17. Cornely OA, Hoenigl M, Lass-Florl C, Chen SC, Kontoyiannis DP, Morrissey CO, Thompson GR 3rd; Mycoses Study Group Education and Research Consortium (MSG-ERC) and the European Confederation of Medical Mycology (ECMM). Defining breakthrough invasive fungal infection-Position paper of the mycoses study group education and research consortium and the European Confederation of Medical Mycology. Mycoses. 2019 Sept;62(9):716-729. doi: 10.1111/myc.12960. PMCID: PMC6692208.

Contact Us

Dr. Martin Hoenigl
Email: mhoenigl@ucsd.edu

Dr. Jeffrey Jenks
Email: jjenks@ucsd.edu
Phone: (619) 471-9250

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