Clinical and Translational Fungal Research - Working Group (CTFR-WG)

About the Working Group

Invasive fungal infections are an increasing threat for immunocompromised individuals and associated with devastating morbidity and mortality. Clinicians and Researchers at UCSD have come together and founded a multidisciplinary working group (Clinical and Translational Fungal Research - Working Group). The CTFR-WG is dedicated to advancing the understanding, diagnostics and management of invasive fungal infections. In 2018, the working group completed two studies on point-of-care diagnosis of invasive aspergillosis, and on impact of combination antifungal therapy on survival in rare mold infections, and was very active in disseminating their research findings in a total of 8 Pub Med listed publications. 

Members

Martin Hoenigl, PhD
Assistant Professor;
President of the European
Confederation of Medical
Mycology, FECMM
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Jeffrey Jenks, MD, MPH
Assistant Professor
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Nancy Law, DO
Assistant Professor
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Stephen Rawlings, MD
ID Fellow
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Randy Taplitz, MD
Professor
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Sharon Reed, MD
 Professor
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 Sanjay Mehta, MD
 Assistant Professor
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Cathy Logan, MD
Assistant Professor
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Ongoing Projects
  • Aspergillus and other Rare Mold Infections at UC San Diego Health (IRB #181119; PI Jenks)
  • Novel Diagnostic Approaches for Invasive Pulmonary Aspergillosis (IRB #171104; PI Hoenigl)
  • FungiScope Global Emerging Fungal Infections registry (IRB #171105; PI Hoenigl)

Clinical Trials

  • SCY-078-206: Study to Evaluate the Safety and Efficacy of the Combination Therapy of Ibrexafungerp
    (SCY-078) With Voriconazole in Patients With Invasive Pulmonary Aspergillosis (SCYNERGIA)

Publications

  1. Jenks JD, Mehta SR, Taplitz R, Aslam S, Reed SL, Hoenigl M. Point-of-care
    diagnosis of invasive aspergillosis in non-neutropenic patients: Aspergillus
    Galactomannan Lateral Flow Assay versus Aspergillus-specific Lateral Flow Device
    test in bronchoalveolar lavage. Mycoses. 2018 Dec 18. doi: 10.1111/myc.12881.
    [Epub ahead of print] PubMed PMID: 30565352.
  2. Jenks JD, Salzer HJF, Hoenigl M. Improving the rates of Aspergillus detection:
    an update on current diagnostic strategies. Expert Rev Anti Infect Ther. 2019
    Jan;17(1):39-50. doi: 10.1080/14787210.2018.1558054. Epub 2018 Dec 17. PubMed
    PMID: 30556438.
  3. Jenks JD, Mehta SR, Taplitz R, Law N, Reed SL, Hoenigl M. Bronchoalveolar
    lavage Aspergillus Galactomannan lateral flow assay versus Aspergillus-specific
    lateral flow device test for diagnosis of invasive pulmonary Aspergillosis in
    patients with hematological malignancies. J Infect. 2018 Nov 2. pii:
    S0163-4453(18)30319-0. doi: 10.1016/j.jinf.2018.10.014. [Epub ahead of print]
    PubMed PMID: 30391632.
  4. Jenks JD, Hoenigl M. Treatment of Aspergillosis. J Fungi (Basel). 2018 Aug
    19;4(3). pii: E98. doi: 10.3390/jof4030098. Review. PubMed PMID: 30126229; PubMed
    Central PMCID: PMC6162797.
  5. Jenks JD, Reed SL, Seidel D, Koehler P, Cornely OA, Mehta SR, Hoenigl M. Rare
    mould infections caused by Mucorales, Lomentospora prolificans and Fusarium, in
    San Diego, CA: the role of antifungal combination therapy. Int J Antimicrob
    Agents. 2018 Nov;52(5):706-712. doi: 10.1016/j.ijantimicag.2018.08.005. Epub 2018
    Aug 9. PubMed PMID: 30099056; PubMed Central PMCID: PMC6231988.
  6. Jenks JD, Salzer HJ, Prattes J, Krause R, Buchheidt D, Hoenigl M. Spotlight on
    isavuconazole in the treatment of invasive aspergillosis and mucormycosis:
    design, development, and place in therapy. Drug Des Devel Ther. 2018 Apr
    30;12:1033-1044. doi: 10.2147/DDDT.S145545. eCollection 2018. Review. PubMed
    PMID: 29750016; PubMed Central PMCID: PMC5933337.
  7. Jenks JD, Mehta SR, Hoenigl M. Broad spectrum triazoles for invasive mould infections
    in adults: Which drug and when? Med Mycol. 2019 Apr 1; 57 (Supplement_2):S168-S178.
    doi: 10.1093/mmy/myy052. PMID: 30816967
  8. Hoenigl M. Fungal Translocation: A driving force behind the Occurrence of non-AIDS Events?
    Clin Infect Dis. 2019 Mar 12; pii: ciz215. doi: 10.1093/cid/ciz215. PMID: 30861074

Contact Us

Dr. Martin Hoenigl
Email:mhoenigl@ucsd.edu

Dr. Jeffrey Jenks
Email:jjenks@ucsd.edu
Phone: (619) 471-9250

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