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Publications

2021

Immunohorizons©ImmunoHorizons
Distal Lck Promoter-Driven Cre Shows Cell Type-Specific Function in Innate-like T Cells
Figueroa MG, Parker LM, Krol K, Zhao M. Distal LckPromoter-Driven Cre Shows Cell Type-Specific Function in Innate-like T Cells. Immunohorizons. 2021 Sep 28;5(9):772-781. doi: 10.4049/immunohorizons.2100079. PMID: 34583938.



Supported by the MARC through the Pilot Project Grant program.
Calcium signals regulate the functional differentiation of thymic iNKT cells.
Zhao M, Quintana A, Zhang C, Andreyev AY, Kiosses W, Kuwana T, Murphy A, Hogan PG, Kronenberg M. Calcium signals regulate the functional differentiation of thymic iNKT cells. EMBO J. 2021 Aug 16;40(16):e107901. doi: 10.15252/embj.2021107901. Epub 2021 Jun 25. PMID: 34169542; PMCID: PMC8365263. Reproduced with permission from EMBO
              
 
Supported by the MARC through the Pilot Project Grant program.

Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation
Xian H, Liu Y, Rundberg Nilsson A, Gatchalian R, Crother TR, Tourtellotte WG, Zhang Y, Aleman-Muench GR, Lewis G, Chen W, Kang S, Luevanos M, Trudler D, Lipton SA, Soroosh P, Teijaro J, de la Torre JC, Arditi M, Karin M, Sanchez-Lopez E. Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation. Immunity. 2021 Jul 13;54(7):1463-1477.e11. doi: 10.1016/j.immuni.2021.05.004. Epub 2021 Jun 10. PMID: 34115964; PMCID: PMC8189765.
 Supported by the MARC through the Pilot Project Grant program.

EMJ Innovations
Triggers, Timescales, and Treatments for Cytokine-Mediated Tissue Damage
McBride DA, Kerr MD, Dorn NC, Ogbonna DA, Santos EC, Shah NJ. Triggers, Timescales, and Treatments for Cytokine-Mediated Tissue Damage. Euro Med J Innov. 2021 Feb;5(1):52-62. doi: 10.33590/emjinnov/20-00203. Epub 2020 Dec 9. PMID: 34013158; PMCID: PMC8130813.



Supported by the MARC through the Pilot Project Grant program.




2020

JCI Insight October 2020
PTPN2 links colonic and joint inflammation in experimental autoimmune arthritis
Hsieh WC, Svensson MN, Zoccheddu M, Tremblay ML, Sakaguchi S, Stanford SM, Bottini N. PTPN2 links colonic and joint inflammation in experimental autoimmune arthritis. JCI Insight. 2020 Oct 15;5(20):141868. doi: 10.1172/jci.insight.141868. PMID: 33055428.
Journal of Medicine and Surgical Sciences.
A novel bioengineered material to reverse intervertebral disc degeneration
Daisuke Fukui, Koichi Masuda, Michael Zimber, Stephanie Y. Adachi, Natsuko Arimoto, Jeong Ho Kim, … Gail K. Naughton*. A Novel Bioengineered Material to Reverse Intervertebral Disc Degeneration. Journal of Medicine and Surgical Sciences, 2020 May, 2(1), 1–10. http://doi.org/10.5281/zenodo.3777266.


Science Advances June 2020
Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal
Svensson MND, Zoccheddu M, Yang S, Nygaard G, Secchi C, Doody KM, Slowikowski K, Mizoguchi F, Humby F, Hands R, Santelli E, Sacchetti C, Wakabayashi K, Wu DJ, Barback C, Ai R, Wang W, Sims GP, Mydel P, Kasama T, Boyle DL, Galimi F, Vera D, Tremblay ML, Raychaudhuri S, Brenner MB, Firestein GS, Pitzalis C, Ekwall AH, Stanford SM, Bottini N. Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal. Sci Adv. 2020 Jun 26;6(26):eaba4353. doi: 10.1126/sciadv.aba4353. PMID: 32637608; PMCID: PMC7319753.

Highlighted in Natural Reviews Rheumatology: Therapies targeting FLS and TNF can have synergistic effects (November 2020)
Biomaterials Science
Characterization of regulatory T cell expansion for manufacturing cellular immunotherapies.
McBride DA, Kerr MD, Wai SL, Yee YY, Ogbonna DA, Shah NJ. Characterization of
regulatory T cell expansion for manufacturing cellular immunotherapies. Biomaterials
science. 2020 May 22. PubMed PMID: 32441280; DOI: 10.1039/d0bm00622j.


Supported by the MARC through the Pilot Project Grant program.
Arthritis and Rheumatology May 2020
Differential DNA Methylation of Networked Signaling, Transcriptional, Innate and Adaptive Immunity, and Osteoclastogenesis Genes and Pathways in Gout
 Wang Z, Zhao Y, Phipps-Green A, Liu-Bryan R, Ceponis A, Boyle DL, Wang J, Merriman TR, Wang W, Terkeltaub R. Differential DNA Methylation of Networked Signaling, Transcriptional, Innate and Adaptive Immunity, and Osteoclastogenesis Genes and Pathways in Gout. Arthritis Rheumatol. 2020 May;72(5):802-814. doi: 10.1002/art.41173. Epub 2020 Mar 23. PMID: 31738005; PMCID: PMC7323903.

Supported by the MARC through the Pilot Project Grant program.
Cells v.9 coverpage
Hypoxia-Inducible Factor-1α: The Master Regulator of Endothelial Cell Senescence in Vascular Aging
Alique M, Sánchez-López E, Bodega G, Giannarelli C, Carracedo J, Ramírez R. Hypoxia-Inducible Factor-1α: The Master Regulator of Endothelial Cell Senescence in Vascular Aging. Cells. 2020 Jan 13;9(1):195. doi: 10.3390/cells9010195. PMID: 31941032; PMCID: PMC7016968. 


Supported by the MARC through the Pilot Project Grant program.

2019

Wires 2019

Applications of Molecular Engineering in T-cell-based Immunotherapies
McBride DA, Kerr MD, Wai SL, Shah NJ. Applications of molecular engineering in T-cell-based immunotherapies. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2019 Sep;11(5):e1557. doi: 10.1002/wnan.1557. Epub 2019 Apr 10. PMID: 30972976; PMCID: PMC7869905.



Supported by the MARC through the Pilot Project Grant program.