Publications

2020

PTPN2 links colonic and joint inflammation in experimental autoimmune arthritis

Hsieh WC, Svensson MN, Zoccheddu M, Tremblay ML, Sakaguchi S, Stanford SM, Bottini N. PTPN2 links colonic and joint inflammation in experimental autoimmune arthritis. JCI Insight. 2020 Oct 15;5(20):141868. doi: 10.1172/jci.insight.141868. PMID: 33055428.

Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal

Svensson MND, Zoccheddu M, Yang S, Nygaard G, Secchi C, Doody KM, Slowikowski K, Mizoguchi F, Humby F, Hands R, Santelli E, Sacchetti C, Wakabayashi K, Wu DJ, Barback C, Ai R, Wang W, Sims GP, Mydel P, Kasama T, Boyle DL, Galimi F, Vera D, Tremblay ML, Raychaudhuri S, Brenner MB, Firestein GS, Pitzalis C, Ekwall AH, Stanford SM, Bottini N. Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal. Sci Adv. 2020 Jun 26;6(26):eaba4353. doi: 10.1126/sciadv.aba4353. PMID: 32637608; PMCID: PMC7319753.

Highlighted in Natural Reviews Rheumatology: Therapies targeting FLS and TNF can have synergistic effects (November 2020)

Characterization of regulatory T cell expansion for manufacturing cellular immunotherapies.

McBride DA, Kerr MD, Wai SL, Yee YY, Ogbonna DA, Shah NJ. Characterization of
regulatory T cell expansion for manufacturing cellular immunotherapies. Biomaterials
science. 2020 May 22. PubMed PMID: 32441280; DOI: 10.1039/d0bm00622j.

Differential DNA Methylation of Networked Signaling, Transcriptional, Innate and Adaptive Immunity, and Osteoclastogenesis Genes and Pathways in Gout

Wang Z, Zhao Y, Phipps-Green A, Liu-Bryan R, Ceponis A, Boyle DL, Wang J, Merriman TR, Wang W, Terkeltaub R. Differential DNA Methylation of Networked Signaling, Transcriptional, Innate and Adaptive Immunity, and Osteoclastogenesis Genes and Pathways in Gout. Arthritis Rheumatol. 2020 May;72(5):802-814. doi: 10.1002/art.41173. Epub 2020 Mar 23. PMID: 31738005; PMCID: PMC7323903.

Hypoxia-Inducible Factor-1α: The Master Regulator of Endothelial Cell Senescence in Vascular Aging

Alique M, Sánchez-López E, Bodega G, Giannarelli C, Carracedo J, Ramírez R. Hypoxia-Inducible Factor-1α: The Master Regulator of Endothelial Cell Senescence in Vascular Aging. Cells. 2020 Jan 13;9(1):195. doi: 10.3390/cells9010195. PMID: 31941032; PMCID: PMC7016968.