The Joint Bioinformatics and Computational (JBC) Core offers a variety of services including:
- Senior Faculty and Project Scientist Consulting: to assist study design and assessment of multi-dimensional data including epigenomics, genomics, and other structured data.
- Single cell analysis: Eliminate batch effects, clustering and identify cell sub-populations.
- Gene transcriptional network analysis (Taiji): Leverage epigenomic and transcriptomic data using integrative models to elucidate disease mechanisms, including transcription factors that participate in pathogenesis.
- Implementation of machine learning methods to datasets such as:
- Neural networks
- classification and regression methods (such as random forest and UMAP)
- Whole genome sequencing analysis: Variant calling and pathway enrichment analysis.
EpiSig analysis example integrating 9 separate omics databases to identify genes in rheumatoid arthritis that are epigenetically distinguished from controls.
How to get started
Submit a service request form to the JBC Core. A core director or core manager will get back to you for an initial meeting (no cost to you). In this meeting, you will need to let us know:
- Overall goal of study
- Datasets to be analyzed
- Desired outcomes from data analysis
Costs and ways to lower costs
Core Leadership & Contacts
|Gary Firestein, MD, Core Co-Director|
Wei Wang, PhD, Core Co-Director
|Richard Ainsworth, Core Manager|
Alisa Prewett, MARC Coordinator