Located on UC San Diego's beautiful La Jolla campus, the Antonio De Maio laboratory is investigating the molecular and genetic bases of the response to injury. Traumatic injury is a major cause of mortality and morbidity in the United States, particularly among children. The De Maio research group has found that the response to injury is modulated by several confounding factors including genetic background, sex, age, diet, and environment. The major factor associated with morbidity and mortality injury is an overwhelming inflammatory response.
The Antonio De Maio group is using mouse genetics to identify genes that regulate the inflammatory process as potential therapeutic targets. In addition, the Antonio De Maio laboratory is studying the role of heat shock proteins in the regulation of the inflammatory response.The Antonio De Maio Laboratory is actively engaged in the training of basic scientists, future academic surgeons and students at the undergraduate, graduate and medical school levels
Antonio De Maio, Ph.D
Dr. Antonio De Maio is a professor of Surgery and Neuroscience, a member of the Biomedical Sciences Graduate Program (BMS) at UC San Diego, and Director of the Center for Investigations of Health and Education Disparities (CIHED).
A graduate of the Central University of Venezuela in Caracas, Dr. Antonio De Maio received his Ph.D. from the Weizmann Institute of Science in Rehovot, Israel.He joined the faculty at UC San Diego School of Medicine in January 2006.
Prior to joining UCSD, Dr. De Maio was an Associate Professor and Research Director for the Division of Pediatric Surgery at Johns Hopkins University. While at Hopkins, Dr. De Maio led the Committee for the Recruitment of Under-represented Minorities to Graduate Programs and the Post-baccalaureate Research Education Program (PREP). At UC San Diego, Dr. De Maio continues to be very active in increasing student diversity in graduate and medical school.
In 2007, he received a Vice Chancellor of Health Sciences Equal Opportunity/Affirmative Action and Diversity Award. Dr. De Maio is the Director of the Initiative to Maximize Student Development (IMSD) Program at UC San Diego, which is supported by NIGMS-NIH.
De Maio Group Research and Projects
The De Maio laboratory has found that the response to injury is modulated by several confounding factors including genetic background, sex, age, diet and environment. Classical mouse genetics were used to identify modifier genes that regulate the response to injury as potential genetic markers or therapeutic targets. In this regard, macrophage scavenger receptor A was identified as a modifier of the induction of IL-10. In addition, the De Maio laboratory found that the negative outcome from sepsis is related to a condition of innate immune dysfunction.
The De Maio group has been a pioneer in studying the role of heat shock proteins in the regulation of the innate immune system. The major inducible form of heat shock protein family, Hsp70, is actively secreted by cells by an active non-classical mechanism, which is independent of ER-Golgi traffic. The De Maio group found that Hsp70 secretion is initiated by the translocation of the protein into the plasma membrane followed by the released within vesicles.
The De Maio laboratory is investigating the possible therapeutic potential of heat shock proteins in ameliorating the development of Alzheimer’s disease.
Dr. De Maio is actively engaged in the training of undergraduate, graduate, medical students, and Post-docs, particularly students from disadvantaged social and economic backgrounds, students with disabilities, and students from minority groups that are under-represented in science. Additionally, Dr. De Maio actively mentors future academic surgeons and other health-related professionals.
UCSD La Jolla Campus
School of Medicine Building 4