The Mayadev Lab focuses on enhancing the cure through scientific discovery of locally advanced cervical cancer through translational science and clinical trials. The Mayadev lab has a passion to understand the mechanisms of therapeutic response and tumor resistance in cervical cancer. Her lab works on investigations of developmental therapeutic interventions, neoadjuvant strategies with chemoradiation, brachytherapy (internal radiation) optimization, and decreasing disparities in cervical cancer.
The mission of the Mayadev laboratory is to use our clinical experience with locally advanced cervical cancer to better understand and shed light on complex problems. Questions that drive our research include: “Why do certain patients recur with cancer and why do some experience toxicity from our treatment? How can be increase the cure rate for patients with large tumors or those with lymph node spread?” We then use all of our available scientific tools, technology, innovation, team science, and knowledge to answer these questions. Everything we do focuses on this strategy; we are sincerely dedicated to cervical cancer innovation.
We describe an optimization framework to convert brachytherapy dose distributions directly into dwell times.
Our knowledge-based dose prediction model accurately identified cases that could have met constraints without needle supplementation, suggesting that such models may be beneficial for applicator selection.
A simple boundary distance-driven knowledge-based DVH estimation exhibited promising results in predicting critical brachytherapy dose metrics.