The Zuraw lab conducts research in two separate areas, angioedema and asthma. Angioedema studies are focused on bradykinin-mediated swelling, investigating genetic determinants of angioedema severity, the role of bradykinin receptors in swelling, and the cell biology of C1 inhibitor deficiency. In collaboration with the US HAEA Angioedema Center, of which Dr. Zuraw is Director, the laboratory is studying improved assays for the diagnosis of angioedema. Asthma studies focus on the role of the airway epithelial cell in inflammatory airway disease. The laboratory is studying the impact of glucocorticoid-induced leucine zipper (GILZ) in down-regulating airway inflammation as well as the role of B2 and B1 bradykinin receptors as well as transient receptor potential channels in allergic airway inflammation.
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