Latest Grants

BREAST SURGERY

Principal Investigator Research Title Funding Source
Sarah Blair, MDAn improved BREAST MRI contrast using folate targeting and gadolinium oxide nanoparticlesMoores Cancer Center pilot grant
Sarah Blair, MDNon-circulating microparticles for improved localization and resection of cancerNIH-NCI
Anne Wallace, MD, FACSInvestigation of serial studies to predict your therapeutic response with imaging and molecular analysis 2 (ISPY-2 Trial) (2016)
Quantum Leap
Anne Wallace, MD, FACSA Phase II study of intraoperative tumor detection using ratiometric activatable fluorescent peptide in early stage breast cancer patients (2017)Avelas

CARDIOVASCULAR AND THORACIC SURGERY

Principal Investigator Research Title Funding Source
Michael Madani, MD, FACSGrant to establish a national registry for patients who suffer from chronic thromboembolic pulmonary hypertension
Bayer
Mark Onaitis, MDProximalization therapy for KRAS mutant adenocarcinomaVA
Mark Onaitis, MDCTGF as therapeutic target in lung cancerNCI
Mark Onaitis, MDComprehensive evaluation of mesotheliomaDOD
Patricia Thistlethwaite, MD, PhDNotch signaling in pulmonary hypertensionNIH-NHLBI
Patricia Thistlethwaite, MD, PhDSmall molecule inhibitors to treat pulmonary arterial hypertensionNIH-NHLBI

COLON AND RECTAL SURGERY

Principal Investigator Research Title Funding Source
Nicole Lopez, MDBioinformatics fellowshipNIH-NLM
Lisa Parry, MD, FASCRSEducating the next generation of robotic surgeonsAmerican Society of Colon and Rectal Surgeons Robotic Grant

HEPATOBILIARY AND TRANSPLANT SURGERY

Principal Investigator Research Title Funding Source
Tatiana Kisseleva, MD, PhDThe role of portal fibroblasts in cholestatic liver fibrosisNIH
Tatiana Kisseleva, MD, PhDThe role of IL-17 in alcoholic liver disease and cancerNIH
Tatiana Kisseleva, MD, PhDInactivation of hepatic stellate cells during reversal of liver fibrosisNIH
Tatiana Kisseleva, MD, PhDFibrocytes regulate liver fibrosisNIH
Tatiana Kisseleva, MD, PhDEpigenetic regulation of alcoholic liver diseaseNIH
Tatiana Kisseleva, MD, PhDThe role of human serum amyloid protein (SAP) in treatment of liver fibrosisCorporate Award Promedior
Tatiana Kisseleva, MD, PhDTherapeutic role of allogeneic murine mesenchymal precursor cells (MPCs) in inhibition of liver fibrosis in miceMesoblast Inc.
Tatiana Kisseleva, MD, PhDEvaluation of the response of primary human hepatic stellate cells to anti-fibrotic drugsCelgene Corporation
Tatiana Kisseleva, MD, PhDEvaluation of a second genome test compound on activation of primary human hepatic stellate cellsSecond Genome
Tatiana Kisseleva, MD, PhDIsolation of primary liver cells for 3-D printing of the human liverSamsara Sciences, Inc.

MINIMALLY INVASIVE SURGERY

Principal Investigator Research Title Funding Source
Santiago Horgan, MD, FACS Garth Jacobsen, MD, FACSThe evaluation of Magnetic Resonance (MR)-determined Proton Density Fat Fraction (PDFF) as a biomarker in obesityassociated Non Alcoholic Fatty Liver Disease (NAFLD)NIH
Santiago Horgan, MD, FACS Garth Jacobsen, MD, FACSEndoscopic treatment for weight reduction in patients with obesity using the TransPyloric Shuttle® system: a multicenter, prospective, randomized, double-blind, shamcontrolled, parallel-design study (ENDObesity® II study)BAROnova
Santiago Horgan, MD, FACS Garth Jacobsen, MD, FACSA worldwide post-market surveillance registry to assess the Medigus Ultrasonic Surgical Endostapler (MUSETM) system for the treatment of GERDMEDIGUS

NEUROSURGERY

Principal Investigator Research Title Funding Source
Joseph Ciacci, MDResearch support for Dr. CiacciOrthofix
Alexander Khalessi, MD, MS, FAANSexRNA biomarkers for human glioma
National Center for Advancing Translational Sciences
Alexander Khalessi, MD, MS, FAANSResearch support for Dr. KhalessiThe Penny and Robert Sarver Foundation

OTOLARYNGOLOGY/HEAD AND NECK SURGERY

Principal Investigator Research Title Funding Source
Joseph Califano, III, MD, FACSEpigenetic biomarker discovery in HPV related HNSCCDental and Cranial Research, National Cancer Institute
Joseph Califano, III, MD, FACSA novel point of care test for oral and oropharyngeal cancer riskNational Cancer Institute
Joseph Califano, III, MD, FACSOptimizing an assay for high risk HPV DNA in body fluidsNational Cancer Institute
Arwa Kurabi, PhDEstablishment of an animal model of human-specific responses to middle ear infectionNational Institute on Deafness and Other Communications Disorders, NIH
Quyen Nguyen, MD, PhDGenetic and injectable reporters to image tumors and guide resectionNational Cancer Institute
Quyen Nguyen, MD, PhDTesting fluorescently labeled probes for nerve imaging during surgeryNational Institute of Biomedical Imaging and Bioengineering
Quyen Nguyen, MD, PhDSpecialized cancer center core support grantNational Cancer Institute
Quyen Nguyen, MD, PhDA 6-month, multicenter, Phase 3, open-label extension safety study of OTO-104 given at 3-month intervals by intratympanic injection in subjects with unilateral Meniere’s diseaseSyneos Health Inc. Otonomy, Inc.
Quyen Nguyen, MD, PhDRapid 3-D-printing of multi-functional adaptive nerve conduitsChild Health & Human Development, Department of Health & Human Services (DHHS)(FH)
Quyen Nguyen, MD, PhDDose-ranging study of the efficacy and safety of miconazole oil used for 7 or 14 days compared with vehicle in the treatment of otomycosisQST Consultations
Allen Ryan, PhDMechanisms of persistence and recovery in otitis mediaNational Institute on Deafness and Other Communications Disorders, NIH
Allen Ryan, PhD Arwa Kurabi, PhDMiddle ear response in otitis mediaNational Institute on Deafness and Other Communications Disorders, NIH
Allen Ryan, PhDOtolaryngology training in immunology, virology and molecular biologyNational Institute on Deafness and Other Communications Disorders, NIH
Allen Ryan, PhDInnovative therapy for diseases of the middle earU.S. Department of Veterans Affairs
Allen Ryan, PhDA biological interface for auditory rehabilitation with a cochiea implantU.S. Department of Veterans Affairs

SURGICAL ONCOLOGY

Principal Investigator Research Title Funding Source
Joel Baumgartner, MDThe ILEUS study: a Phase 2 randomized controlled trial investigating Alvimopan for enhanced gastrointestinal recovery after cytoreductive surgery and hyperthermic intraperitoneal chemotherapyMerck
Michael Bouvet, MD, FACSDevelopment of near infrared fluorescence-guided surgical navigation and tumor-specific photoimmunotherapy for improved outcomes for GI cancersVA Merit Review Award
Michael Bouvet, MD, FACSTAV-255 viral developmentPeninsula Biomedical
Kaitlyn Kelly, MDSafety and effect of GL-ONC1 administered IV prior to surgery to patients with solid organ cancers undergoing surgeryMerck
Andrew M. Lowy, MD, FACSRO1-RON receptor in pancreatic cancer biology and therapyNIH
Andrew M. Lowy, MD, FACSTranscriptional reprogramming to control pancreatic cancerSU2C / AACR / Lustgarten Foundation
Andrew M. Lowy, MD, FACSRO1-Musahi mediated control of pancreatic cancer growth and progressionNIH/NCI
Andrew M. Lowy, MD, FACSUO1-imaging and molecular correlates of progression in cystic neoplasms of the pancreasNIH/NCI
Andrew M. Lowy, MD, FACSROR1 CAR-T cells for anticancer therapyCA Institute of Regenerative Medicine (CIRM)
Andrew M. Lowy, MD, FACSMolecular strategies for early detection and targeting of cancerNIH/NCI
Andrew M. Lowy, MD, FACSClinical development of a tumor-penetrating peptide for enhanced pancreatic cancer treatmentPancreatic Cancer Action Network
Jason Sicklick, MD, FACSTargeting Imatinib-resistant, KIT-negative cells in human GISTsKristin Ann Carr Foundation
Jason Sicklick, MD, FACSKO8-novel allosteric kinase inhibitors target ImatiniBresistant GISTNIH
Jason Sicklick, MD, FACSR21-defining the germline genomic landscape of a novel GIST multi-tumor syndromePedal the Cause Grant Active
Rebekah White, MD, FACSIrreversible electroporation as an in situ vaccine for pancreatic cancerNIH
Rebekah White, MD, FACSR21-Aptamers as proteomic tools for pancreatic cancer biomarker identification
National Cancer Institute

TRAUMA, SURGICAL CRITICAL CARE, BURNS, AND ACUTE CARE SURGERY

Principal Investigator Research Title Funding Source
Todd Costantini, MD, FACSThe pathogenesis of post-traumatic pulmonary embolism: a prospective multi-center investigation by the CLOTT Study Group (CLOTT)Department of Defense/ Medical Research and Development Program
Todd Costantini, MD, FACSRole of exosomes in mediating the inflammatory response following trauma/hemorrhagic shockHealth Sciences Academic Senate
Todd Costantini, MD, FACSThe human-specific gene CHRFAM7A in leukocytesNIH/National Institute of General Medical Sciences
Antonio De Maio, PhDContribution of cholesterol homeostasis for injury resolutionNIH/National Institute of General Medical Sciences
Antonio De Maio, PhDMentoring young minds to increase diversity in biomedical researchNIH/National Institute of General Medical Sciences
Jay Doucet, MD, MSc, FRCSC, FACSCharlotte E. Hammond FundUC San Diego Foundation (Reoccurring Donation)
Brian Eliceiri, PhDVagus nerve-mediated regulation of tumor-associated leukocytesHealth Sciences Academic Senate
Brian Eliceir, PhD Robert Dorschner, MD, MSc, FRCSC, FACSThe role of the host-defense peptide ECRG4 in mediating inflammation in wound repairSociety for Investigative Dermatology (SID) Sun Pharma-SID Innovation Research Fellowship Grant
Jeanne Lee, MD, FACSPhysiologic signals and signatures with the Accuryn System in intensive care patientsPotrero Medical, Inc.
Elliot Williams, MDThe role of exosomes in mediating the inflammatory response to injurySurgical Infection Society (SIS) Basic or Translational Research Training Fellowship Grant

VASCULAR AND ENDOVASCULAR SURGERY

Principal Investigator Research Title Funding Source
Andrew Barleben, MDH160159, “Expanding patient applicability with polymer sealing ovation alto stent graft IDE study”Endologix, Inc
Andrew Barleben, MDCombined computational-experimental approach to evaluation of abdominal aortic aneurysms following stent graft placement to mitigate endoleak and late graft failureNIH, National Center for Advancing Translational Sciences (NCATS) and the UC San Diego HRPP
Andrew Barleben, MDSAFE MANTA pivotal IDE studyEssential Medical
John Lane III, MD, FACSBest endovascular versus best surgical therapy in patients with critical limb ischemia (BEST-CLI). NIH sponsored prospective, randomized clinical trial NCT02060630National Institutes of Health
John Lane III, MD, FACSPivotal study of the MicroVention, Inc. carotid artery stent system used in conjunction with the Nanoparasol® embolic protection system for the treatment of carotid artery stenosis in patients at elevated risk for adverse events from carotid endarterectomy (CONFIDENCE Trial) NCT02908880MicroVention-Terumo, Inc.
John Lane III, MD, FACSProspective, multicenter, single arm safety and effectiveness study of endovascular abdominal aortic aneurysm repair using the Nellix® system: a pivotal and continued access study NCT02908880Endologix, Inc.
John Lane III, MD, FACSA prospective, randomized, adaptive, double-blind, shamcontrolled, multicenter study to evaluate the ROX coupler in subjects with hypertension NCT02895386ROX Medical, Inc
John Lane III, MD, FACSA Phase 3 study to compare the efficacy and safety of Humacyte’s human acellular vessel with that of an autologous arteriovenous fistula in subjects with end stage renal disease NCT03183245Humacytel, Inc
John Lane III, MD, FACSProspective, multicenter, single arm safety and effectiveness confirmatory study of endovascular abdominal aortic aneurysm repair using the Nellix system IDE study (EVAS 2 confirmatory IDE study)Endologix, Inc