Jisook Lee, PhD

Jisook Lee, PhD

Assistant Project Scientist


Contact Information


Lab Location:
Hillcrest, CTF B307

Research Overview

The normal brain consists of many different cell types (endothelial cell, astrocytes, microglia, neuron) that communicate with each other to maintain homeostasis and perform normal functions of the brain. However, various injuries to the central nervous system such as traumatic brain injury, stroke, and brain tumors disrupt the normal communication between these different cell types causing blood-brain barrier breakdown, astrogliosis, and inflammation. Cerebral inflammation in particular involves several mediators including activation of resident astrocytes and microglia, infiltration of leukocytes, and release of proinflammatory cytokines and chemokines at the site of injury. My research interest is understanding the kinetics and mechanism of host responses upon brain injuries, especially focusing on determining novel secreted factors that mediate cell-to-cell communication, with the goal of identifying molecular therapeutic targets to maximize the inflammatory response with minimizing damage to the brain.