My research is primarily focused on clinical investigations in the diagnosis, treatment and surveillance of patients with peritoneal metastases from a variety of primary tumors. As a surgical oncologist who treats patients with this condition by performing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC); I am interested in better understanding the disease processes, predicting short- and long-term outcomes, and improving treatments in this disease. I am seeking to better understand the the immunologic, genetic, histopathologic, and clinical landscape of these tumors by investigating the natural history, clinical factors, banked tumor tissue, and blood collected from patients with peritoneal metastases. I am attempting to use this data to predict various outcomes - including complications of treatment, ability to perform effective treatment, progression from primary tumor to peritoneal dissemination, disease recurrence, and death – using carefully curated clinical data from UCSD and beyond. Finally, I am attempting to improve treatments of this disease by investigating novel treatments in clinical trials and reviewing the efficacy of existing therapies.
I am also interested in the clinical investigation of cutaneous malignancies – primarily melanoma. I am collaborating on multiple clinical trials of novel therapies for these tumors and am assisting with an autologous tumor infiltrating lymphocyte program at UCSD.
The ILEUS Study: A Phase 2 Randomized Controlled Trial Investigating Alvimopan for Enhanced Gastrointestinal Recovery after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
Role: Principal Investigator
Funding Agency: Merck
Dates of funding: 12/1/17-12/1/19 (approximate)
Baumgartner JM, Kwong TG, Ma GL, Messer K, Kelly KJ, Lowy AM.
A Novel Tool for Predicting Major Complications After Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy. Ann Surg Oncol. 2016 May; 23(5):1609-17. PMID: 26678406.
Marmor RA, Kelly KJ, Lowy AM,
Laparoscopy is Safe and Accurate to Evaluate Peritoneal Surface Metastasis Prior to Cytoreductive Surgery. Ann Surg Oncol 2016;23(5):1461-7.
Baumgartner JM, Tobin L, Heavey SH, Kelly K, Roeland EJ, Lowy AM.
Predictors of Progression in High-Grade Appendiceal or Colorectal Peritoneal Carcinomatosis after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy. Ann Surg Oncol 2015;22(5):1716-1721.
PMP Pals Conference: Dr. Joel Baumgartner Shares UCSD's Experience with the Genetics of PMP
Surgical Management of Appendix Cancer