Inhibition of NOTCH3 Cleavage Reverses Pulmonary Arterial Hypertension in Animal Models, UCSD Researchers Find
Pulmonary arterial hypertension (PAH), a form of high blood pressure in the lung's arteries, affects more than 100,000 people in the United States, causing approximately 20,000 deaths per year. UC San Diego researchers have discovered a key pathway that controls this proliferative process – the NOTCH3 signaling pathway.