Inhibition of NOTCH3 Cleavage Reverses Pulmonary Arterial Hypertension in Animal Models, UCSD Researchers Find

Pulmonary arterial hypertension (PAH), a form of high blood pressure in the lung's arteries, affects more than 100,000 people in the United States, causing approximately 20,000 deaths per year. UC San Diego researchers have discovered a key pathway that controls this proliferative process – the NOTCH3 signaling pathway. 

UCSD's Lung Cancer Program Takes Off

The Division of Cardiovascular and Thoracic Surgery is internationally recognized as a leader in the field of cardiothoracic surgery, especially in the surgical treatment of chronic pulmonary emboli through a procedure called pulmonary thromboendarterectomy. Now, the Division's general thoracic surgery enterprise is expanding to include increased access to highly specialized, multidisciplinary care for lung cancer patients; preventative screenings; and increasing use of minimally invasive and robotic techniques.