Sunil Advani Lab
A long-time focus of the Advani Lab has been on the understanding and overcoming of tumor radio-resistance. An R01 funded tenured faculty,
Dr. Advani and his colleagues have focused on cell signaling pathways involving the PAK-RAF signaling axis. They recently demonstrated that non-canonical, kinase independent functions of RAF mediates cell cycle progression and radio-resistance through phosphorylation of CRAF at serine 338 by PAK. In parallel, the lab is developing tumor-targeted delivery approaches to ultra-potent tumoricidal drugs that have the dual advantage of also radio-sensitizing.