What is Translational Research?
Translational research in neuroscience involves interactions between preclinical “bench” neuroscientists and clinical “bedside” neuroscientists. Translational science involves non-human and non-clinical (basic science) studies conducted with the specific intent to discover mechanisms, biomarkers, or treatments of nervous system disorders, and clinical studies that provide a foundation for developing or directly testing novel therapeutic strategies for humans.
At TRIPEC, we have created a new kind of research environment. We develop research models based upon preclinical studies and apply them to humans. A traditional translational approach is to develop models that extend human studies to animal paradigms in order to study analogous constructs. Alternatively, we use a ‘‘reverse translational’’ approach where existing measures of behavior (exploration, psychophysiological, or cognitive) in animals can be adapted to study the same behavior in people with neuropsychiatric disorders.