Founding Members & Collaborators

Scott C. Matthews, M.D.
Staff Psychiatrist, Veterans Affairs San Diego Healthcare System
Associate Professor of Psychiatry, University of California San Diego


After receiving his M.D. from UMDNJ-New Jersey Medical School, Dr. Matthews completed his internship and residency in psychiatry at the University of California San Diego (UCSD), and was Chief Resident at UCSD Outpatient Psychiatric Services in his final year of residency. He then completed formal research training in functional brain imaging in UCSD’s NIH-funded Fellowship in Biological Psychiatry and Neuroscience. Dr. Matthews is currently Assistant Professor of Psychiatry in Residence at UCSD, Lead Psychiatrist on the Polytrauma Support Clinic Team at Veterans Affairs San Diego Healthcare System (VASDHS), Director of the VASDHS Special Fellowship in Advanced Psychiatry, and former Chief of the Consultation-Liaison Division of the Psychiatry Service at VASDHS. He is a Diplomate of the American Board of Psychiatry and Neurology, an active member of the American Psychosomatic Society (APS), former Co-Chair of the APS Program Committee, and current member of the Editorial Board of Journal of Affective Disorders. In addition to his research and clinical duties, Dr. Matthews is actively involved in teaching residents and medical students.

Dr. Matthews has used neuroimaging methods to increase understanding of the structural and functional neural correlates of normal and abnormal cognitive and emotional processing. He has published several papers indicating that major depressive disorder (MDD) is associated with dysregulated activity of brain systems involved in processing and regulating emotion. His current research program, which is funded by the Department of Veterans Affairs and the Congressionally Directed Medical Research Program (CDMRP), focuses on using structural and functional neuroimaging in veterans exposed to combat in Operation Iraqi Freedom and Operation Iraqi Freedom to identify how blasts disrupt brain structure and function and increase risk of MDD.


I-Wei Shu, MD PhD
Staff Psychiatrist, Moores Cancer Center at UC San Diego Health

Dr. Shu received his PhD in Neurosciences from Mount Sinai School of Medicine in New York City in 2004 and his MD from University of California Davis School of Medicine in 2006. He completed his psychiatry residency at University of California San Diego (UCSD) in 2010. He is a board-certified psychiatrist with a special interest in the neurobiology of anxious and depressive symptoms, especially in patients coping with stressful or traumatic events. Dr. Shu’s current studies involve developing EEG biomarkers that can objectively monitor and predict the course of PTSD symptoms, including response to treatment.

Before joining UC San Diego Health in 2014, Dr. Shu was a staff psychiatrist at the Veterans Affairs San Diego Healthcare System and on the psychiatric consult staff for UC San Diego Jacobs Medical Center and San Diego Hospice. He has also served as a member of San Diego Psychiatric Society's Ethics Committee.


Irina A. Strigo, Ph.D.
Assistant Professor of Psychiatry, University of California San Diego

Dr. Strigo joined our faculty in 2007 after completing a joint post-doctoral fellowship with the UCSD Department of Psychiatry and the Barrow Neurological Institute Atkinson Pain Research Laboratory in Phoenix, Arizona. She received her Ph.D. and B.Sc. in Physiology from McGill University in Montreal, Canada. The Canadian Institute of Health Research funded her doctoral studies, which entailed psychophysical, pharmacological and fMRI analysis of visceral and cutaneous pain in humans.

Dr. Strigo uses psychophysical and brain imaging approaches to study experimental pain perception in various psychiatric disorders, such as Major Depression, Post Traumatic Stress Disorder, Eating Disorders and Traumatic Brain Injury. The long-term goal of this research is to understand the mechanisms leading to co-morbidities between chronic pain and psychiatric conditions. Her research is funded by the National Institute of Mental Health (NIMH) and National Alliance for Research in Schizophrenia and Depression (NARSAD).