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Selected Publications

  • Elenara da Fonseca Andrade Procianoy; · Fernando Antônio de Abreu e Silva; ·Paulo José Cauduro Maróstica; Paul M. Quinton. "Chloride Conductance, Nasal Potential Difference and Cystic Fibrosis Pathophysiology." Lung  198(1):151-156, 2020.
  • Carla Cristina Souza Gomez1 · Paloma Lopes Francisco Parazzi1 · Karl Jan Clinckspoor2 ·Renan Marrichi Mauch1 · Francisco Benedito Teixeira Pessine2 · Carlos Emilio Levy3 · Andressa Oliveira Peixoto1 ·Maria Ângela Gonçalves Oliveira Ribeiro1 · Antônio Fernando Ribeiro1 · Douglas Conrad4 · Paul Marquis Quinton5 ,·Fernando Augusto Lima Marson1,· José Dirceu Ribeiro1. "Safety, Tolerability, and Effects of Sodium Bicarbonate Inhalation in Cystic Fibrosis", Clin Drug Investig.  40(2):105-117,  2020
  • Shamsuddin, A. K. M. and P. M. Quinton. Concurrent Absorption and Secretion of Airway Surface Liquids and Bicarbonate Secretion in Human Bronchioles." American Journal of Physiology. Lung cellular and molecular physiology, 316(5):L953- L960, 2019
  • Dobay, O., Laub, K., Stercz, B., Keri, A., Balazs, B., Tothpal, A., Kardos, S., Jaikumpun, P., Ruksakiet, K., Quinton, P. M., Zsembery, A. Bicarbonate Inhibits Bacterial Growth and Biofilm Formation of Prevalent Cystic Fibrosis Pathogens. Front Microbiol 9: 2245, 2018.
  • Quinton, P. M.. 'Both Ways at Once: Keeping Small Airways Clean', Physiology (Bethesda), 32: 380-90. 2017
  • Salinas D B, Kang L, Azen C, and Quinton P.  Low Beta-Adrenergic Sweat Responses in Cystic Fibrosis and Cystic Fibrosis Transmembrane Conductance Regulator-Related Metabolic Syndrome Children, Ped Allergy Immunol Pulmon, 30:2-6, 2017.
  • Flores-Delgado, G., C. Lytle, P.M. Quinton.  Site of Fluid Secretion in Small Airways.  Am J Respir Cell Mol Biol.. Mar 12, 2016.
  • Ferkol, T., and P. Quinton. 2015. Precision Medicine: At What Price? Am J Respir Crit Care Med 192:658-659.
  • Orenstein, D.M., B.P. O'Sullivan, and P.M. Quinton. 2015. Cystic Fibrosis: Breakthrough Drugs at Break-the-Bank Prices. Glob Adv Health Med 4:8-57.
  • Shamsuddin, A.K., and P.M. Quinton. Native small airways secrete bicarbonate. Am J Respir Cell Mol Biol 50:796-804, 2014.
  • Shepherd, S.L., E.J. Goodrich, J. Desch, and P.M. Quinton. Rebuttal from Mr Shepherd et al. Chest 145:684-685, 2014.
  • Shepherd, S.L., E.J. Goodrich, J. Desch, and P.M. Quinton. Counterpoint: does the risk of cross infection warrant exclusion of adults with cystic fibrosis from cystic fibrosis foundation events? No. Chest 145:680-683, 2014.
  • Quinton, P.  The Time is Now:  The Critical Need for Increased Research Funding, CFRI News, Spring 2014
  • Quinton, P.M., G., D. Worlitzsch. Obituary Gerd Döring.  The International Journal of Biochemistry & Cell Biology, 52:5-6, 2014
  • Quinton, P. M. 2014. 'A synopsis of methods of sweat tests in pathology', Clin Biochem, 47: 757-8.
  • Yang, N., M.A. Garcia, and P.M. Quinton. Normal mucus formation requires cAMP-dependent HCO3- secretion and Ca2+-mediated mucin exocytosis. J Physiol 591:4581-4593, 2013. 
  • Cooper, JL, P Quinton, and Ballard. Mucociliary Transport in Porcine Trachea: Differential Effects of Inhibiting Chloride and Bicarbonate Secretion. Am J Physiol Lung Cell Mol Physiol 304:L184-190, 2013.
  • Quinton, P.  ¿Que es la investigacion? ECOS de FIPAN, April 2013
  • Quinton, P., L. Molyneux, W. Ip, A. Dupuis, J. Avolio, E. Tullis, D. Conrad, A.K. Shamsuddin, P. Durie, and T. Gonska.  Beta-adrenergic sweat secretion as a diagnostic test for cystic fibrosis. Am J Respir Crit Care Med 186:732-739, 2012.
  • Shamsuddin, A.K., and P.M. Quinton. Surface fluid absorption and secretion in small airways. J Physiol 590:3561-3574, 2012.
  • Quinton, P.  A New View: Cystic Fibrosis, Mucus, and Baking Soda.  CFRI News, Fall 2011
  • Chen EY, Yang N, Quinton PM, and Chin WC.  A New Role for Bicarbonate in Mucus Formation. Am J Physiol Lung Cell Mol Physiol 299:L542-549, 2010.
  • RW Muchekehu and PM Quinton.  Mucus release in the female reproductive tract is critically dependent on bicarbonate.  J Physiol 588: 2329-2342, 2010.
  • Gonska T, Ip W, Turner D, WonSun Han, Rose J, Durie P, Quinton P.  Sweat gland bioelectrics differ in cystic fibrosis: a new concept for potential diagnosis and assessment of CFTR function in cystic fibrosis. Thorax. Nov;64(11):932-8, 2009.
  • Garcia MA, Yang N, and Quinton PM. Normal mouse intestinal mucus release requires cystic fibrosis transmembrane regulator-dependent bicarbonate secretion. J Clin Invest 119: 2613-2622, 2009.
  • Reddy, MM and Quinton, PM. PKA Mediates Constitutive Activation of CFTR in Human Sweat Duct.  J. Membrane Biol. 2009 Oct;231(2-3):65-78
  • Reddy MM, Wang XF, Quinton PM. Effect of Cytosolic pH on Epithelial Na(+) Channel in Normal and Cystic Fibrosis Sweat Ducts. J Membr Biol 225: 1-11, 2008.
  • Shamsuddin AK, Reddy MM, Quinton PM. Iontophoretic {beta}-adrenergic Stimulation of Human Sweat Glands: Possible Assay for CFTR Activity In Vivo. Exp Physiol. 2008 Apr 25.
  • Quinton PM. Cystic Fibrosis: Impaired HCO3- Secretion and Mucoviscidosis. Lancet. In Press.
  • Quinton PM. Too much salt, too little soda: cystic fibrosis. Sheng Li XueBao. 2007 Aug 25;59(4):397-415.
  • Quinton PM. Cystic fibrosis: lessons from the sweat gland. Physiology (Bethesda). 2007 Jun;22(3):212-25
  • Wang X, Lytle C, Quinton PM. Predominant constitutive CFTR conductance in small airways. Respir Res. 2005 Jan 17;6(1):7-19.
  • Reddy MM, Wang XF, Gottschalk M, Jones K, Quinton PM. Normal CFTR Activity and Reversed Skin Potentials in Pseudohypoaldosteronism. J Membr Biol. 2005 Feb;203(3):151-9.
  • Reddy MM, Quinton PM. Control of dynamic CFTR selectivity by glutamate and ATP in epithelial cells. Nature. 2003 12 June 2003;423:756 - 60.
  • Quinton PM. The neglected ion: HCO3. Nature medicine. 2001 Mar;7(3):292-3.
  • Reddy MM, Light MJ, Quinton PM. Activation of the epithelial Na+ channel (ENaC) requires CFTR Cl- channel function. Nature. 1999 Nov 18;402(6759):301-4.
  • Quinton PM. Physiological basis of cystic fibrosis: a historical perspective. Physiol Rev. 1999 Jan;79(1):S3-S22.
  • Quinton PM. Human genetics. What is good about cystic fibrosis? Curr Biol. 1994 Aug 1;4(8):742-3.
  • Joris L, Dab I, Quinton PM. Elemental composition of human airway surface fluid in healthy and diseased airways. Am Rev Respir Dis. 1993 Dec;148(6 Pt 1):1633-7.
  • Quinton PM, Reddy MM. Control of CFTR chloride conductance by ATP levels through non-hydrolytic binding. Nature. 1992 Nov 5;360(6399):79-81.
  • Quinton PM. Cystic fibrosis. Righting the wrong protein. Nature. 1990 Sep 20;347(6290):226.
  • Reddy MM, Quinton PM. Localization of Cl- conductance in normal and Cl- impermeability in cystic fibrosis sweat duct epithelium. Am J Physiol. 1989 Oct;257(4 Pt 1):C727-35.
  • Riordan J, Burns J, Tsui LC, Reddy MM, Quinton P, Buchwald M. Utilization of cultured epithelial cells from the sweat gland in studies of the CF defect. ProgClinBiol Res. 1987;254:59-71.
  • Joris L, Quinton PM. Concentration of elements in airway surface fluid. Medical Science Research. 1987;15:855-6.
  • Quinton PM, Bijman J. Higher bioelectric potentials due to decreased chloride absorption in the sweat glands of patients with cystic fibrosis. N Engl J Med. 1983 May 19;308(20):1185-9.
  • Quinton PM. Chloride impermeability in cystic fibrosis. Nature. 1983 Feb 3;301(5899):421-2.
  • Quinton PM. Composition and control of secretions from tracheal bronchial submucosal glands. Nature. 1979 Jun 7;279(5713):551-2.
  • Quinton PM. Techniques for microdrop analysis of fluids (sweat, saliva, urine) with an energy-dispersive X-ray spectrometer on a scanning electron microscope. Am J Physiol. 1978 Mar;234(3):F255-9.
  • Prompt CA, Quinton PM. Functions of calcium in sweat secretion. Nature. 1978 Mar 9;272(5649):171-2.
  • Quinton PM, Tormey JM. Localization of Na/K-ATPase sites in the secretory and reabsorptive epithelia of perfused eccrine sweat glands: a question to the role of the enzyme in secretion. J Membr Biol. 1976 Nov 29;29(4):383-99.
  • Quinton PM, Philpott CW. A role for anionic sites in epithelial architecture. Effects of cationic polymers on cell membrane structure. J Cell Biol. 1973 Mar;56(3):787-96.