Paul M. Quinton, Ph.D.
Nancy Olmsted Chair in Pediatric Pulmonology
Professor of Pediatrics, UC San Diego
Professor of Biomedical Sciences, UC Riverside
Specialty: Epithelial Fluid and Electrolyte Transport Physiology
Dr. Paul Quinton, who has CF himself, discovered that the basic defect in the CF sweat duct was due to anion impermeability and not defective anion exchange. His discovery is considered to be one of the major advances in understanding the basic CF defect.
The research of the Quinton Laboratory is focused to better understand the roles fluid, electrolyte, and mucus movements of epithelia in Cystic Fibrosis and other obstructive lung diseases. We apply electrophysiological, imaging, micro-manipulation, molecular biological and biochemical approaches to investigate the mechanisms of normal and pathophysiological functions in affected epithelia. Studies include sweat gland, airway,reproductive, and gastrointestinal intestinal organs with an emphasis on native tissue ex vivo. Specific interests include the control and role of CFTR (the defective protein expressed in Cystic Fibrosis), in ion secretion and absorption processes, and the interaction of electrolytes with mucins. We specialize in multiple forms of micro-techniques to pursue.