Principal Investigator

Dr. Donald Durden, MD, PhD (Bio)
Vice Chair of Research, Department of Pediatrics, UC San Diego and Rady Children’s Hospital, San Diego Associate Director for Pediatric Oncology, Moores UC San Diego Cancer Center and UC San Diego School of Medicine 

 Project Scientist 

Shweta Joshi, PhD: Dr. Joshi is investigating the signaling pathways in macrophages controlling tumor metastasis and M2 macrophage activation in tumor microenvironment. She identified a signal transduction pathway in macrophages which extends from the provisional integrin, α4β1 through a kinase/GTPase pair (Syk-Rac2) to control tumor metastasis in vivo. She is also studying the signaling pathways which controls M2 macrophage differentiation in setting of bleomycin induced lung fibrosis, liver fibrosis and other diseases driven by M2 macropages. Dr. Joshi is also engaged in studying microRNAs controlling M1-M2 macrophage polarization.

Staff Research Associate

Muamera Zulcic: Zulcic is engaged in the study of the role of Rac2-Syk signaling pathway in macrophages which is required for tumor growth, angiogenesis, and metastasis. She is supporting post docs and also managing the laboratory.




Adam Burgoyne, MD, PhD: Dr. Burgoyne is a senior clinical fellow in hematology/oncology studying rationally designed dual-specificity inhibitors of PI3K and BRD4 as novel therapeutic agents for hepatocellular carcinoma (HCC). His work focuses on characterizing the interplay between PI3K signaling and the bromodomain-regulated epigenome in HCC to develop a bioinformatically-driven method for predicting sensitivity to rationally designed targeted therapeutics in HCC. He is also involved in the translation of these mechanistic and preclinical studies into early phase clinical trials in HCC patients.


Student Interns

Corey Cheung
Boss Le
Archana Mukthavaram
Apurwa Adwait Shukla

Past Lab Members

Afshan Ahman (Student)
Alok Singh (Project Scientist)
Amanda Amarasinghe (Lab Assistant)
Amanda Goldin (Resident)
Andrew Martin (MD Fellow)
Cassandra Wang (Student)
Carlos Noworny (Student)
Felix To (Student)
Francisco Vega (Visiting Scholar)
Michael Alcaraz (Lab Assistant)
Mingyu Hu (Student)
Mrudula Bhuvanagiri (Student)
Jasmine Massoumi (Student)
Joshua Lange (Student)
Lisa Hartman (MD Fellow)
Mohar Chattopadhyay, Ph.D. (Postdoctoral Fellow)
Nicholas LaCivita (Student)
Salvatore Fanale (Staff Research Associate)
Sharanbir Gill (Student)
Tracey Huynh (Student)