The Life and Death of Neutrophils
The production, function, and death of neutrophils is critical for host defense against pathogens. The laboratory studies a novel phenomena called
shuttling, which involves the transfer of intracellular pathogens from neutrophils to macrophages. We also investigate how cell death signaling controls cytokine secretion, NET formation, neutrophil lifespan, and chronic inflammatory diseases.
Sudden Infant Death Syndrome (SIDS)
The KCNJ8 potassium channel supports cardiac function following infection. Without the channel, mammals are sensitized 20,000-fold to infection leading to sudden cardiac failure. Mutations in KCNJ8 have been identified in a subset of sudden infant death syndrome (SIDS) cases, suggesting that infection and cardiovascular instability contributes to this devastating syndrome. Genes controlling the cardiovascular response to infection are being investigated.