Neutrophils

Humans produce 100 billion neutrophils every day, and even more following infection, so how do mammals control neutrophil number? The laboratory studies how cell death signaling regulates the generation of neutrophil extracellular traps (NETs), cytokine secretion, and cell death.

Inflammatory cell death

Neutropenia has long been associated with morbidity and mortality, and conversely, accumulation of neutrophils in tissues is a hallmark feature of many acute and chronic inflammatory diseases. We study inflammatory cell death signals that override homeostatic neutrophil survival signals during infection and inflammation.

SIDS

The KCNJ8 potassium channel supports cardiac function following infection. Without  the channel, mammals are sensitized 20000-fold to infection leading to sudden cardiac failure. Mutations in KCNJ8 have been identified in a subset of sudden infant death syndrome (SIDS) cases, suggesting that infection and cardiovascular instability contributes to this devastating syndrome.