Chemical Biology and Drug Development

  • ​Chiu YL, Dinesh CU, Chu CY, Ali A, Brown KM, Cao H and Rana TM. (2005) Dissecting RNA-interference pathway with small molecules. Cell Chem Biol, 12, 643-648. DOI: 10.1016/j.chembiol.2005.04.016
  • Ali A, Reddy GK, Cao H, Anjum SG, Nalam M, Schiffer C A, and Rana TM. (2006) Discovery of HIV-1 protease inhibitors with picomolar affinities incorporating N-aryl-oxazolidinone-5-carboxamides as novel P2 ligands. Journal of Medicinal Chemistry, 49, 7342-7356. DOI: 10.1021/jm060666p
  • Nathans R, Cao H, Sharova N, Ali A, Sharkey M, Stranska R, Stevenson M, and Rana TM. (2008) Small-molecule inhibition of HIV-1 Vif. Nature Biotechnology, 26, 1187-1192. DOI: 10.1038/nbt.1496
  • Baigude H, Ahsanullah Li, Z Zhou, Y and Rana, TM. (2012) miR-TRAP: a benchtop chemical biology strategy to identify microRNA targets. Angewandte Chemie, 51, 5880-5883. DOI: 10.1002/anie.201201512
  • Li Z and Rana T M. (2012) A kinase inhibitor screen identifies small-molecule enhancers of reprogramming and iPS cell generation. Nature Communications, 3, 1085. DOI: 10.1038/ncomms2059.
  • Mohammed I, Parai M, Jiang X, Sharova N, Singh G, Stevenson M, and Rana TM. (2012) SAR and lead optimization of an HIV-1 Vif-APOBEC3G axis inhibitor. ACS Medicinal Chemistry Letters, 3, 465-469. DOI: 10.1021/ml300037k
  • Li Z and Rana TM. (2014). Therapeutic targeting of microRNAs: current status and future challenges. Nature Reviews Drug Discovery, 13, 622-638. DOI: 10.1038/nrd4359
  • Mohammed I, Kummetha I R, Singh G, Sharova N, Lichinchi G, Dang J, Stevenson M, and Rana TM. (2016) 1,2,3-Triazoles as amide bioisosteres: Discovery of a new class of potent HIV-1 Vif antagonists. Journal of Medicinal Chemistry, 59, 7677-7682. DOI: 10.1021/acs.jmedchem.6b00247.
  • Johnson T, Chin M, Han T, Shen J, Rana T, Siegel D. (2016) Synthesis of eupalinilide E a promoter of human hematopoietic stem and progenitor cell expansion. Journal of the American Chemical Society, 138, 6068-6073. DOI: 10.1021/jacs.6b03055.