Postdoctoral Scholar:

Postdoctoral Fellowships in immunotherapy, RNA Biology, Medicinal Chemistry, and Chemical Biology

Available immediately for highly motivated recent PhDs and/or MDs with strong training in biochemistry, bioinformatics, immunology, molecular and cell biology, virology, medicinal chemistry or chemical biology to participate in the following projects involving multidisciplinary teams of clinicians and basic science investigators: (a) investigate immunotherapy and immune exhaustion mechanisms by using CRISPR and RNAi; (b) identify RNA modification roles in regulating host-pathogen interactions by performing biochemical and HT genomics studies; (c) develop and employ cancer stem cell based disease models; (d) identification and synthesis of new drug candidates to treat cancer and viral infections. Technologies employed in our projects include single cell genomics, bioinformatics, HT RNA-seq, gene editing, in vitro and vivo models for immunotherapy to treat cancer and viral infections, computational drug design and synthesis. Strong publication record and training to perform independent research are required for further consideration. We highly value and encourage applications from minority groups. For examples of our multidisciplinary work and technologies used in our work: see Cancer Research, 2017 Nov 15;77(22):6330-6339; Cell Stem Cell, 2016 Aug 4;19(2):258-65; Cell Host Microbe. 2016 Nov 9;20(5):666-673. doi: 10.1016/j.chom.2016.10.002; Cancer Research, 2016 Oct 1;76(19):5777-5787. Nature Microbiology, Article number: 16011 (2016) doi:10.1038/nmicrobiol.2016.11; J Med Chem, 2016 Aug 25;59(16):7677-82; Nat Rev Drug Discov. 2014, 622-38, Molecular Cell. 2014, 1005-19; Proc Natl Acad Sci USA. 2014,1002-7; Cell Stem Cell. 2014, 523-34; Cell Reports. 2014, 327-37; Genome Biol. 2013, R149, Nature Commun. 2012, 1085, EMBO J. 2011, 823-34, Molecular Cell, 2009, 696, Nature Biotechnology, 2008, 1187-92, J Med Chem. 2012, 6328, ACS Med Chem Lett. 2012, and http://biomedsci-db.ucsd.edu/faculty_detail?f=249

Successful Candidates will be part of a stimulating and collaborative scientific environment with cutting-edge instrumentation and facilities.

Applicants should send CV and names and addresses of three references to: ranaoffice@ucsd.edu  , Kira Chaiboonma, Administrative Coordinator, Rana Laboratory, Division of Genetics, Department of Pediatrics, Moores Cancer Center, Institute for Genomic Medicine, and Center for Drug Discovery Innovation, University of California San Diego, La Jolla, California, USA.

PhD Students:

If you are interested in pursuing your PhD in the Rana Lab, please apply through the Biomedical Sciences Graduate Program. 
Please keep in mind that international applicants are required to complete a Pre-Application due prior to the full application due date.

Undergraduate Students:

MS/BS in Biology


Desired Qualifications:
Must have a strong desire and commitment to perform scientific research in human disease mechanisms. Must have an understanding of biochemistry, bioinformatics, chemistry, cell biology, or molecular biology. Prior lab experience is a plus.

Documents to Submit: Resume, Cover Letter, Unofficial Transcript

Send Materials to: Rana Lab. ranaoffice@ucsd.edu  

Projects Available:

Research opportunities are available in a multidisciplinary laboratory studying fundamental questions in Immunobiology and RNA biology. Ongoing projects include: (1) Bioinformatics and systems medicine using HT genome sequencing of blood cells from cancer and AIDS patients. (2) CRISPR-Cas9 applications in immune system engineering. (3) Developing new approaches for cancer immunotherapies.

Additional Info: Under supervision of a postdoctoral fellow or a staff scientist, you will be exposed to: bioinformatics analyses of large genomics data sets, culturing and differentiation of stem cells, drug discovery, viral transduction, RNA and DNA isolation, PCR and gel electrophoresis, transfection, western blot, in vivo and in vitro cancer models, and lab maintenance. For additional information about projects and publications, see http://biomedsci-db.ucsd.edu/faculty_detail?f=249

Rotation Projects

Lab Rotation Project Title
Role of RNAs in regulating immunotherapy and cancer stem cells

Lab Rotation Project Description
There are two projects available in the lab. (a) in-vivo models are utilized to identify RNAs and their complexes involved in the success and resistance to immunotherapy in melanoma and colon cancers. (b) glioblastoma cancer stem cells are differentiated to generate 3D organoids and to identify RNA modification mechanisms that can be perturbed to selectively destroy cancer stem cells. Both projects involve RNAi, CRISPR-Cas9, inhibitors efficacy and immune exhaustion mechanism analyses. Methods used: stem cell culture, bioinformatics, RNA-Seq, single cell RNA-Seq, HT library preparation and sequencing, CRISPR-Cas9 knockout cells, mouse models.

Project Duration
12 Weeks