Publications

  1. Bi-Huei Yang, Ke Wang, Shuo Wan, Yan Liang, Xiaomei Yuan, Yi Dong, Sunglim Cho, Wanqing Xu,  Kristen Jepsen, Gen-Sheng Feng, Li-Fan Lu, Hai-Hui Xue, and Wenxian Fu. TCF1 and LEF1 control Treg competitive survival and Tfr development to prevent autoimmune diseases. Cell Reports (in press)

  2. Ying W*, Lee YS*, Dong Y*, Seidman JS, Yang M, Isaac R, Seo JB, Yang B, Wollam J, Riopel M, McNeils J, Glass CK, Olefsky JM‡, Fu W‡. Expansion of islet-resident macrophages leads to inflammation affecting beta cell proliferation and function in obesity. Cell Metabolism. 2019. 29: 457-474.  Preview by Spadaro and Dixit in Immunity. Highlighted in Nature Rev. Endo.

  3. Kraakman MJ, Liu Q, Postigo-Fernandez J, Ji R, Kon N, Larrea D, Namwanje M, Fan L, Chan M, Area-Gomez E, Fu W, Creusot RJ, Qiang L. PPARγ deacetylation dissociates thiazolidinedione's metabolic benefits from its adverse effects. J Clin Invest. 2018 May 14. pii: 98709. doi: 10.1172/JCI98709. [Epub ahead of print] PubMed PMID: 29589839.

  4. Yuan X, Dong Y, Tsurushita N, Tso JY and Fu W. CD122 blockade restores immunological tolerance in autoimmune type 1 diabetes via multiple mechanisms. JCI Insight. 2018;3(2):e96600. doi:10.1172/jci.insight.96600.

  5. Chen K, Jih A, Osborn O, Kavaler ST, Fu W, Sasik R, Saito R, Kim JJ. Distinct gene signatures predict insulin resistance in young mice with high fat diet-induced obesity. Physiol Genomics. 2018 Jan 8. dos: 10.1152/physiolgenomics.00045.2017. [Epub ahead of print] 

  6. Yuan X, Yang B, Dong Y, Yamamura A and Fu W. CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells. eLife 2017;6:e29540 DOI: 10.7554/eLife.29540. 

  7. Lee J, Liao R, Wang G, Yang BH, Luo X, Varki NM, Qiu SJ, Ren B, Fu W, Feng GS. Preventive Inhibition of Liver Tumorigenesis by Systemic Activation of Innate Immune Functions. Cell Rep. 2017 Nov 14;21(7):1870-1882

  8. Ying W, Riopel M, Bandyopadhyay G, Dong Y, Birmingham A, Seo JB, Ofrecio JM, Wollam J, Hernandez-Carretero A, Fu W, Li P, Olefsky JM. Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity. Cell. 2017 Oct 5;171(2):372-384

  9. Cho S, Wu CJ, Nguyen D, Lin LL, Chen M, Khan A, Yang B, Fu W and Lu L. A novel miR-24-TCF1 axis in modulating effector T cell responses. Journal of Immunology. 2017. 198:3919-3926.

  10. Fu W, Farache J, Clardy S, Hattori K, Mander P, Lee K, Rioja I, Weissleder R, Prinjha R, Benoist C, Mathis D. Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells. eLife. 2014. 10.7554/eLife.04631. Journal cover; highlighted in eLife. 2014;3:e05720; N Engl J Med. 2015. 372: 778-80

  11. Gutierrez D, Fu W, Schonefeldt S, Feyerabend T, Ortiz-Lopez A, Lampi Y, Liston A, Mathis D, Rodewald H. Type 1 Diabetes in NOD Mice is Unaffected by Mast Cell Deficiency. Diabetes. 2014. 63:3827-34.

  12. Engin F, Yermalovich A, Ngyuen T, Hummasti S, Fu W, Eizirik D, Mathis D, Hotamisligil G. Restoration of the Unfolded Protein Response in Pancreatic Beta Cells Protects Mice Against Type 1 Diabetes. Science Translational Medicine. 2013. 5: 211ra156. [Highlighted Nat Rev Endocrinology. 2014.10:129-30]

  13. Fu W, Ergun A, Lu T, Hill JA, Haxhinasto S, Fassett MS, Gazit R, Adoro S, Glimcher L, Chan S, Kastner P, Rossi D, Collins JJ, Mathis D and Benoist B. A multiply redundant genetic switch 'locks in' the transcriptional signature of T regulatory cells. Nature Immunology. 2012. 13: 972–980. Highlighted in Nat Immunol. 2012.13:943-5.

  14. Fu W, Wojtkiewicz G, Weissleder R, Benoist C and Mathis D. Early window of diabetes determinism in NOD mice, dependent on the complement receptor CRIg, identified by noninvasive imaging. Nature Immunology. 2012. 13: 361-368. Journal Cover. Highlighted in Nat. Rev. Immunol. 2012. 12:230-1; Nat. Immunol. 2012. 13:311-2.

  15. Fu W, Zhang J and Chen W. Cloning and Characterization of Mouse Homolog of the CXC Chemokine Receptor CXCR1. Cytokine. 2005. 31: 9-17.

  16. Fu W*, Gong S*, Qian X, Li Y, Zhu M, Dong X, Li Y and Chen W. Differential chemotactic potential of mouse platelet basic protein for thymocyte subsets. Cellular and Molecular Life Sciences. 2004. 61:1935-1945. (*co-first authors).

  17. Fu W and Chen W. Roles of Chemokines in Thymopoiesis: Redundancy and Regulation. Review. Cellular and Molecular Immunology. 2004. 1:266-273.

  18. Fu W, Zhu M, Gong S, Li Y and Chen W. Molecular cloning and characterization of a novel rat CXC chemokine, rPBP, the homologue of human and mouse PBP. Cytokine. 2004. 26: 37-43.

  19. He X, Li J, Qian X, Fu W, Li Y, Wu L and Chen W. The thymic stromal cell line MTSC4 induced thymocyte apoptosis in a non-MHC-restricted manner. Cell Research. 2004. 14: 125-133.

  20. Jin C, Fu W, Xie L, Qian X and Chen W. SDF-1a production is negatively regulated by mouse estrogen enhanced transcript in a mouse thymus epithelial cell line. Cellular Immunology. 2003. 223:26-34.

  21. Li Y, Fu W, Zhu M and Chen W. Prokaryotic expression, purification and chemotaxis analysis of a novel murine CXC chemokine MTCK1/mPBP. Chinese Journal of Microbiology and Immunology. 2003 23:459-463.

  22. Xie L*, Fu W*, Jin C, Dong X and Chen W. Negative regulation of monocyte chemoattractant protein-1 gene expression by a mouse estrogen enhanced transcript. European Journal of Immunology. 2002.32:2837-2846. (*co-first authors).

  23. Gong S, Qian X, Fu W and Chen W. Cloning of a Murine cDNA and Its Human Homolog Encoding Transcription Factor like Proteins. Chinese Journal of Biochemistry and Molecular Biology. 2001. 17:280-287.