Wenxian Fu, PhD

Pediatric Diabetes Research Center (PDRC)

Assistant Professor, UCSD Department of Pediatrics               

phone: 858-246-0022
e-mail: w3fu@ucsd.edu

Fu Lab website​

BIOGRAPHY

Dr. Fu received his Ph.D. in Immunology at Peking University, China, where he studied the role of chemokines in immune cell migration and maturation. Dr. Fu did his postdoctoral training first at Joslin Diabetes Center and then at the Department of Microbiology and Immunobiology, Harvard Medical School, Boston, where his research has focused on the pathogenesis of autoimmune type 1 diabetes and the molecular mechanisms of Foxp3+ regulatory T cells.

RESEARCH INTERESTS

Dr. Fu’s research focuses on the immune regulatory mechanisms that lead to type 1 diabetes with the goal of discovering new preventive and therapeutic strategies.  His lab is also exploring new imaging methods for predicting the risk of developing type 1 diabetes before patients are diagnosed with the disease.

RECENT PUBLICATIONS

Yuan X, Yang B, Dong Y, Yamamura A and Fu W. CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells. eLife. 2017. 10.7554/eLife.29540.

Yuan X, Dong Y, Tsurushita N, Tso JY and Fu W. CD122 blockade restores immunological tolerance in autoimmune type 1 diabetes via multiple mechanisms. JCI insight (in press)

Chen K, Jih A, Osborn O, Kavaler ST, Fu W, Sasik R, Saito R, Kim JJ. Distinct gene signatures predict insulin resistance in young mice with high fat diet-induced obesity. Physiol Genomics. 2018 Jan 8. dos: 10.1152/physiolgenomics.00045.2017. [Epub ahead of print] 

Lee J, Liao R, Wang G, Yang BH, Luo X, Varki NM, Qiu SJ, Ren B, Fu W, Feng GS. Preventive Inhibition of Liver Tumorigenesis by Systemic Activation of Innate Immune Functions. Cell Rep. 2017 Nov 14;21(7):1870-1882.

Ying W, Riopel M, Bandyopadhyay G, Dong Y, Birmingham A, Seo JB, Ofrecio JM, Wollam J, Hernandez-Carretero A, Fu W, Li P, Olefsky JM. Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity. Cell. 2017 Oct 5;171(2):372-384.e12.

Cho S, Wu CJ, Nguyen DT, Lin LL, Chen MC, Khan AA, Yang BH, Fu W, Lu LF. A Novel miR-24-TCF1 Axis in Modulating Effector T Cell Responses. J Immunol. 2017. May 15;198(10):3919-3926. 

Fu W, Wojtkiewicz G, Weissleder R, Benoist C and Mathis D. Early window of diabetes determinism in NOD mice, dependent on the complement receptor CRIg, identified by noninvasive imaging. Nature Immunology. 2012. 13: 361-368. (Journal Cover)  

Fu W, Ergun A, Lu T, Hill JA, Haxhinasto S, Fassett MS, Gazit R, Adoro S, Glimcher L, Chan S, Kastner P, Rossi D, Collins JJ, Mathis D and Benoist C. A multiply redundant genetic switch ‘locks in’ the transcriptional signature of T regulatory cells. Nature Immunology. 2012. 13: 972–980.

Engin F, Yermalovich A, Nguyen T, Hummasti S, Fu W, Eizirik D, Mathis D, Hotamisligil G. ATF6-dependent restoration of defective beta cell UPR with TUDCA protects mice against type 1 diabetes. Science Translational Medicine. 2013. 5:211ra156.

Gutierrez D, Fu W, Schonefeldt S, Feyerabend T, Ortiz-Lopez A, Lampi Y, Liston A, Mathis D, Rodewald H. Type 1 Diabetes in NOD Mice is Unaffected by Mast Cell Deficiency. Diabetes (online advanced publication).​   

Fu W, Farache J, Clardy S, Hattori K, Mander P, Lee K, Rioja I, Weissleder R, Prinjha R, Benoist C,Mathis D. Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages andβ cells. eLife. 2014. 10.7554/eLife.04631. [Journal cover; highlighted in eLife. 2014;3:e05720; NEngl J Med. 2015. 372: 778-80]