Pediatric Diabetes Research Center (PDRC)
Professor, UCSD Department of Pediatrics
Dr. Jianhua Shao is a professor in the Department of Pediatrics. His medical education began overseas at Xinxiang Medical College, China, where he received his MD degree and practiced as an endocrinologist.
In 1992, Dr. Shao began his basic research career, earning his PhD degree from the Beijing Medical University. During his postdoctoral training at Case Western Reserve University and University of Colorado Health Sciences Center, he studied insulin signaling abnormalities in human and mouse models of gestational diabetes.
Dr. Shao was appointed as a faculty member of the Graduate Center for Nutritional Sciences at the University of Kentucky in 2004, where he taught in the graduate program and continued his basic research of obesity and diabetes.
Dr. Shao’s research is focused on understanding how maternal metabolism influences the development of obesity and diabetes in offspring.
Qiao, L., Yoo, H., Bosco, C., Lee, B., Feng, G., Schaack, J., Chi, N. and J. Shao. Adiponectin reduces thermogenesis by inhibiting brown adipose tissue activation in mice. Diabetologia. 2014, 57: 1027-1036.
Lee, B., Qiao, L., Brice, K., Feng, G. and J. Shao. Macrophage Depletion Disrupts Immune Balance and Energy Homeostasis. PLoS ONE. 2014, 9(6).
Lee, B., Qiao, L., Lu, M., Yoo, HS., Wai, C., Mak, R., Schaack, J., Feng, G.., Chi, NW., Olefsky, and J. Shao. C/EBPα regulates macrophage activation and systemic metabolism. American journal of physiology. Endocrinology and metabolism. 2014, 306: E1144-54.
Yoo, HS., Qiao, L., Bosco, C., Leong, LH., Lytle, N., Feng, GS., Chi, NW., and J. Shao. Intermittent Cold Exposure Enhances Fat Accumulation in Mice. PLoS ONE. 2014, 9(5).
Li, S., Hsu, D. D., Li, B., Luo, X., Alderson, N.. Qiao, L., Ma, L., Zhu, H. H., He, Z., Suino, Powell, K., Ji, K., Li, J., Shao, J., Xu, H. E., Li, T., Feng, G. S. Cytoplasmic Tyrosine Phosphatase Shp2 Coordinates Hepatic Regulation of Bile Acid and FGF15/19 Signaling to Repress Bile Acid Synthesis. Cell Metabolism. 2014, 20(2): 320-332.
Zhong L, Ding Y, Bandyopadhyay G, Waaler J, Borgeson E, Smith S, Zhang M, Phillips SA, Mahooti S, Mahata SK, Shao J, Krauss S, Chi NW. The PARsylation activity of tankyrase in adipose tissue modulates systemic glucose metabolism in mice. Diabetologia. 2016;59(3):582-91. Epub 2015/12/04. doi: 10.1007/s00125-015-3815-1. PubMed PMID: 26631215.
Zhong L, Yeh TY, Hao J, Pourtabatabaei N, Mahata SK, Shao J, Chessler SD, Chi NW. Nutritional energy stimulates NAD+ production to promote tankyrase-mediated PARsylation in insulinoma cells. PLoS One. 2015;10(4):e0122948. Epub 2015/04/16. doi: 10.1371/journal.pone.0122948. PubMed PMID: 25876076; PMCID: Pmc4395342.
Qiao L, Guo Z, Bosco C, Guidotti S, Wang Y, Wang M, Parast M, Schaack J, Hay WW, Jr., Moore TR, Shao J. Maternal High-Fat Feeding Increases Placental Lipoprotein Lipase Activity by Reducing SIRT1 Expression in Mice. Diabetes. 2015;64(9):3111-20. Epub 2015/05/08. doi: 10.2337/db14-1627. PubMed PMID: 25948680; PMCID: Pmc4542442.