Opportunities and Challenges
In contrast with other genetic modification techniques, which are typically designed to minimize inheritance or transmission of altered genetic elements, the goal of a gene drive is to rapidly spread genetic information throughout a population. This makes it especially important to minimize the potential for unintended consequences. Reducing the potential for unintended consequences will require a combination of confinement and containment strategies. For active genetics to target pathogenic or antibiotic resistant bacteria, technical challenges will include selection of optimal delivery systems, e.g. bacteriophage or conjugal transfer, that can be deployed in environmental or clinical settings.