|October 21, 2020 | Features Victor Nizet, MD|
Start-up Receives up to $15 M to Develop Nanoparticle Therapy for Sepsis Licensed from UC San Diego
San Diego-based Cellics Therapeutics, which was co-founded by UC San Diego nanoengineering Professor Liangfang Zhang, has received an award of up to $15M from Boston-based accelerator CARB-X to develop a macrophage cellular nanosponge—nanoparticles cloaked in the cell membranes of macrophages—designed to treat sepsis.
|October 19, 2020 | Features Mark Sawyer, MD|
Two from San Diego named to governor’s COVID-19 vaccine safety panel
Two San Diego physicians are among 11 experts statewide tasked with determining the quality of any new coronavirus vaccines released in the United States.
Gov. Gavin Newsom announced the COVID-19 Scientific Safety Review Workgroup Monday, promoting the panel as an independent body capable of scrutinizing the trial results and risk assessments associated with any vaccine approved for release by the U.S. Food and Drug Administration.
|September 23, 2020 | Features Tariq Rana, PhD|
Statins Reduce COVID-19 Severity, Likely by Removing Cholesterol That Virus Uses to Infect
There are no Food and Drug Administration (FDA)-approved treatments for COVID-19, the pandemic infection caused by a novel coronavirus. While several therapies are being tested in clinical trials, current standard of care involves providing patients with fluids and fever-reducing medications. To speed the search for new COVID-19 therapies, researchers are testing repurposed drugs — medicines already known to be safe for human use because they are FDA-approved for other conditions — for their abilities to mitigate the virus.
|September 9, 2020 | Features Alysson Muotri, PhD|
How the Coronavirus Attacks the Brain
It’s not just the lungs — the pathogen may enter brain cells, causing symptoms like delirium and confusion, scientists reported. The coronavirus targets the lungs foremost, but also the kidneys, liver and blood vessels. Still, about half of patients report neurological symptoms, including headaches, confusion and delirium, suggesting the virus may also attack the brain.
August 19, 2020 | Features Jane Burns, MD
New Data on How Many Kids Got That Covid Mystery Illness
A few young patients also develop strange inflammatory symptoms. A CDC report sheds light on how widespread this syndrome is, and what it could mean for vaccines. AS STUDENTS GO back to school across the United States, the assumption that children and teens play little role in spreading Covid-19 is taking a beating. One Georgia school district quarantined more than 900 students and adults. At another in Mississippi, more than 100 students were sent home. One Indiana high school didn’t even make it through a full day—and on Monday, the entire University of North Carolina reversed course on in-person learning and went fully remote.
|August 19, 2020 | Features Rob Knight, PhD|
Human microbiome trims mucosal glycans, influencing SARS-CoV-2 infection
An international team of researchers has conducted a study showing that differences in the human microbiome may influence the ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to infect host cells. These microbiome differences may help to explain why older individuals and men are more susceptible to developing coronavirus disease 19 (COVID-19), compared with younger individuals and women, says the team.
August 4, 2020 | Features Sandra Leibel, MD
Researchers Growing Mini-Lungs To Study Coronavirus Impacts On Different Race, Gender
San Diego scientists are growing mini-lungs from a diverse set of stem cells to see how COVID-19 impacts the organ. Researchers are hoping the study shows how coronavirus affects people from different backgrounds. Researchers collected stem cells from people with different racial backgrounds and gender and then used them to grow organoids, or small functioning organs, in Petri dishes.
|August 3, 2020 | Features Tariq Rana, PhD|
Inhibiting Enzyme Helps Cancer Immunotherapy Work Better
People with inactive RNA-editing enzyme respond better to immunotherapy; inhibitors of the enzyme help mice with difficult-to-treat cancers live longer.
Cancer immunotherapy — a treatment that better enables a patient’s own immune system to attack tumors — has shown great potential against some cancers. Yet immunotherapy doesn’t work against all tumor types, and many patients who initially respond later develop resistance and relapse.
|July 31, 2020 | Features Alysson Muotri, PhD|
How Zero Gravity Can Reveal Basic Biological Questions
Astronauts have conducted all sorts of experiments in the International Space Station—from observations of microgravity on the human to body to growing space lettuce. But recently, cosmonauts bioengineered human cartilage cells into 3D structures aboard the station, using a device that utilizes magnetic levitation.
July 29, 2020 | Features Stephanie Cherqui, PhD
Best Life: Experimental Treatment for Cystinosis Featuring Dr. Stephanie Cherqui
The Department of Pediatrics is excited to share this news clip that highlights Dr. Stephanie Cherqui’s experimental gene therapy approach to treating cystinosis. Stem cells taken from patient’s peripheral blood were re-engineered to produce functional cystinosin, the protein defective in cystinosis. The patient was then reinfused with his own cystinosin-producing cells.
|July 28, 2020 | Features Rob Knight, PhD|
Watcher in the Wastewater
Research groups around the globe are looking to see whether urban wastewater monitoring can be integrated into surveillance systems for SARS-CoV-2 and other pathogens. After COVID-19 lockdowns eased across the United States in June, some parts of the country began reporting sudden increases in new cases. Texas was among the states leading the surge, and Houston in particular emerged as a national hotspot.
|July 24, 2020 | Features Stephen Spector, MD|
National Clinical Trial Launches, Will Test Promising Vaccine Against Novel Coronavirus
UC San Diego Health and the Altman Clinical and Translational Research Institute, part of UC San Diego School of Medicine, will be sites for an accelerated national clinical trial to assess the efficacy and immunogenicity of a vaccine intended to protect against SARS-CoV-2, the novel coronavirus that causes COVID-19.
July 23, 2020 | New Publication
Seema Aceves and team identified a new signaling pathway in eosinophilic eshophagitis that could lead to new therapeutics
Increased production of LIGHT by T Cells in eosinophilic esophagitis promotes differentiation of esophageal fibroblasts toward an inflammatoryphenotype.