The Division of Neonatology contains a very productive group of cellular, molecular, and translational investigators. Division members have recently published in high-impact journals including PNAS, J Biol Chem, PLoS One, and Glia. Research has been supported by both the NIH, foundation, and industry sources. Investigators have presented data at many National and International meetings and received multiple awards.
Division Faculty members studying the basic mechanisms of disease include Drs. Evan Snyder (neuronal stem cells and disease), Lars Bode (human mild oligosaccharides), Greg Heldt (development of synthetic surfactants), Farhad Imam (genetic response to hypoxia and stress), and Lance Prince (inflammation, immunity, and lung development).
New translational investigations include a Trial of Therapeutic Hypothermia during Transport (Dr. Jose Honold), a Review of Blood Culture Negative Sepsis in Neonates (Dr. Jane O’Donnell), Efficacy of Intravenous Levetiracetam in the Treatment of Neonatal Seizures (Dr. Richard Haas, Dr. Mary J. Harbert, Dr. Brian Lane, Dr. Jose Honold), and Evaluation of Video Laryngoscopy (Dr. Jae Kim).
Lawrence (Lance) Prince, MD, PhD
• Mechanisms linking lung inflammation and abnormal development in bronchopulmonary dysplasia
• Developmental biology of lung macrophages
• Development of novel imaging approaches for understanding neonatal lung disease.
Lars Bode, PhD
• Biosynthesis and physiological function of human milk oligosaccharides
• Role of breast milk and unbound complex glycans in development of the intestinal innate immune response.
• Development of oligosaccharide based therapies to prevent infectious disease and necrotizing enterocolitis.
David Golembeski, MD
• Board member for the National Children’s Study.
• Co-PI for the Boston University Birth Defects Monitoring Project.
Gregory P. Heldt, MD
• Development of synthetic and novel lung surfactants.
• Neural-activated synchronized ventilation and its applications in critically ill neonates.
• Basic molecular and cellular mechanisms of group-B streptococcal infections in neonates.
Jose Honold, MD
• Clinical innovation and interventions that improve outcome in critically ill neonates at highest risk of neurodevelopmental impairment.
Eustratia (Tia) Hubbard, MD
• Clinical investigations aimed at improving outcomes in late preterm infants and patients at risk of feeding difficulties.
Farhad Imam, MD, PhD
• Using novel approaches and experimental models to study the molecular and genetic responses to environmental stress.
• Testing the effects of cellular stress on embryogenesis, particularly heart and brain development, in zebrafish
Jae Hong Kim, MD, PhD
• Understanding development of gastrointestinal motility in preterm infants.
• Developing novel noninvasive approaches to personalize critical care management in neonates.
Michelle Leff, MD
• Interactions between maternal diet, breast milk composition, and development of obesity and diabetes.
Krishelle Leong Marc-Aurele, MD
• Development of novel approaches for counseling families in the prenatal and postnatal setting as part of a multi-disciplinary palliative care model developed specifically for newborns.
Sanjay Nigam, MD
• Systems biology approaches to identify mechanisms of kidney branching morphogenesis.
• Developmental regulation and function of organic acid transporters and the elimination and metabolism of drugs and toxins.
Evan Y. Snyder, MD, PhD
• Stem cell biology
• Discovery of novel molecular and cellular mechanisms that regulate stem cell pluripotency and neuronal differentiation.
• The use of induced pluripotent stem cells to investigate basic disease mechanisms and discover novel treatments specific for individual patients.