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Headshot of Adriana Tremoulet, MD

Adriana Tremoulet, MD, MAS

Division of Host-Pathogen Systems & Therapeutics


EDUCATION
  • Harvard University:  A.B. in Biochemistry, 1995
  • University of California, Los Angeles School of Medicine: M.D.,2000  
POSTGRADUATE TRAINING
  • Cedars-Sinai Medical Center: Pediatric Internship, 2000-2001 
  • Cedars-Sinai Medical Center: Pediatric Residency, 2001-2003
  • University of California, San Diego & Children’s Hospital, San Diego: Pediatric Infectious Disease Fellowship, 2003-2006 
  • University of California, San Diego: Masters of Advanced Studies in Clinical Research, 2005-2008
  • University of California, San Diego: Fellow at the Pediatric Pharmacology Research Unit, 2006-2007
  • University of California, San Diego: National Center of Leadership in Academic Medicine, 2009
PROFESSIONAL EXPERIENCE / POSITIONS:
  • University of California, San Diego: Assistant Professor, Division of Pharmacology and Drug Discovery, Pediatric Pharmacology Research Center, 2007-2013
  • University of California, San Diego/Rady Children’s Hospital San Diego: Associate Director, Kawasaki Disease Research Center, 2007-Present
  • Rady Children’s Specialist San Diego: Pediatric Infectious Disease and Kawasaki Disease specialist, 2007-Present
  • University of California, San Diego: Associate Professor, Division of Host-Microbe and Therapeutic Systems, Pediatric Pharmacology Research Center, 2013-Present
  • University of California, San Diego: Laboratory Director, Pediatric Pharmacology Laboratory, 2013-Present
  • University of California, San Diego: Co-director Altman Clinical Translational Research Unit KL2 Training Program, 2017-Present
HONORS and AWARDS
  • National Science Foundation Incentives for Excellence Scholarship, 1994
  • Harvard College Scholarship, 1995
  • Cary Agassiz Certificate of Merit (Harvard-Radcliffe College), 1995
  • Cum Laude Honors in Biochemistry (Harvard University), 1995
  • Clinical Research Training Program Fellowship (National Institutes of Health), 1998
  • Neonatal Intensive Care Unit Housestaff Award (Cedars-Sinai Hospital), 2001
  • Baxter Pharmaceutical Grant, 2002
  • American Academy of Pediatrics, Perinatal Section Travel Grant, 2005
  • Federation of Clinical Immunology Trainee Travel Award, 2006
  • Cindy Matters Fund Grant (San Diego Padres Foundation), 2006
  • Pediatric Academic Society Travel Grant, 2006
  • Pediatric Academic Society Travel Grant, 2010
  • Premier Abstract Presenter 28th Congress of the International Pediatric Association Award, 2016
  • Award of Excellence for Clinical Research, Rady Children’s Hospital San Diego, 2018
  • 1st Place Abstract for the 20th Inter-American Congress of Pediatrics, 2018
NATIONAL/INTERNATIONAL PROFESSIONAL COMMITTEES
Kawasaki Disease Symposium
  • Invited member, 10th International Kawasaki Disease Symposium Organizing Committee, 2012
  • Invited member, 11th International Kawasaki Disease Symposium Organizing Committee, 2014-2015
  • Invited member, 12th International Kawasaki Disease Symposium Organizing Committee, 2017-2018
Kawasaki Disease Foundation
  • Member, Annual Kawasaki Disease Fundraising Gala Organizing Committee, 2010- Present
  • Co-Chair, Annual Kawasaki Disease Parent Symposium, Rady Children’s Hospital San Diego, 2010-Present
American Heart Association
  • Elected Committee Member, Rheumatic Fever, Endocarditis, and Kawasaki Disease (RFEKD) Section, Cardiovascular Diseases in the Young (Committee Vice Chair 2018 – Present), 2015-Present
Latin American Kawasaki Disease Network (Red de la Enfermedad de Kawasaki en America Latina/REKAMLATINA)
  • Co-founder and Director of Research, 2013-Present

Dr. Tremoulet graduated from Harvard University with a major in Biochemistry and then attended medical school at the University of California, Los Angeles. During medical school, she completed a fellowship at the National Institutes of Health as a Clinical Research Training Program fellow. She then completed her pediatric infectious disease fellowship at the University of California, San Diego, and joined the faculty in 2006 where she is now an Associate Professor in the Division of Host-Microbe Systems and Therapeutics in the Department of Pediatrics. In 2007, Dr. Tremoulet became the Associate Director of the Kawasaki Disease (KD) Research Center at the University of California, San Diego. In this capacity she cares for nearly 1300 children with KD in San Diego County and an additional 100 children annually hospitalized at Rady Children’s Hospital San Diego with KD. She has a passion for pediatric pharmacology and serves as the co-principal investigator of the NIH-funded UC San Diego Research Program in Developmental Pharmacology as well as Co-Director of the UC San Diego Department of Pediatric Clinical Pharmacology Training Program. She leads Phase I through III clinical trials including an FDA Orphan Products Grant funded Phase III clinical trial on the use of infliximab as adjunctive primary therapy in KD as well as Phase I/IIa clinical trials of atorvastatin and anakinra in children with KD and coronary artery damage. Her research interest lies in the interface between pediatric pharmacology and the repurposing of therapies for use in pediatric inflammatory and infectious diseases.
 

  1. Tremoulet AH, Albani S. Immunomics in clinical development: bridging the gap. Expert review of clinical immunology. 2005 May;1(1):3-6.(PMID: 20477648)
  2. Tremoulet AH, Albani S. Novel therapies for rheumatoid arthritis. Expert opinion on investigational drugs. 2006 Nov;15(11):1427-1441.(PMID: 17040201)
  3. Tremoulet AH, Capparelli EV, Patel P, Acosta EP, Luzuriaga K, Bryson Y, Wara D, Zorrilla C, Holland D, Mirochnick M. Population pharmacokinetics of lamivudine in human immunodeficiency virus-exposed and -infected infants. Antimicrob. Agents Chemother. 2007 Dec;51(12):4297-4302.(PMID: 17893155)
  4. Tremoulet AH, Best BM, Song S, Wang S, Corinaldesi E, Eichenfield JR, Martin DD, Newburger JW, Burns JC. Resistance to intravenous immunoglobulin in children with Kawasaki disease. J. Pediatr. 2008 Jul;153(1):117-121.(PMID: 18571548)
  5. Tremoulet AH, Devera G, Best BM, Jimenez-Fernandez S, Sun X, Jain S, Burns JC. Increased incidence and severity of Kawasaki disease among Filipino-Americans in San Diego county. Pediatr. Infect. Dis. J. 2011 Oct;30(10):909-911.(PMID: 21552184)
  6. Tremoulet AH, Jain S, Chandrasekar D, Sun X, Sato Y, Burns JC. Evolution of laboratory values in patients with Kawasaki disease. Pediatr. Infect. Dis. J. 2011 Dec;30(12):1022-1026.(PMID: 21817952)
  7. Onouchi Y, Ozaki K, Burns JC, Shimizu C, Terai M, Hamada H, Honda T, Suzuki H, Suenaga T, Takeuchi T, Yoshikawa N, Suzuki Y, Yasukawa K, Ebata R, Higashi K, Saji T, Kemmotsu Y, Takatsuki S, Ouchi K, Kishi F, Yoshikawa T, Nagai T, Hamamoto K, Sato Y, Honda A, Kobayashi H, Sato J, Shibuta S, Miyawaki M, Oishi K, Yamaga H, Aoyagi N, Iwahashi S, Miyashita R, Murata Y, Sasago K, Takahashi A, Kamatani N, Kubo M, Tsunoda T, Hata A, Nakamura Y, Tanaka T, Abe J, Kobayashi T, Arakawa H, Ichida F, Nomura Y, Miura M, Ikeda K, Hara T, Fukazawa R, Ogawa S, Hamaoka K, Newburger JW, Baker AL, Rowley AH, Shulman ST, Melish ME, Mason WH, Takahashi M, Tremoulet AH. A genome-wide association study identifies three new risk loci for Kawasaki disease. Nat. Genet. 2012 Mar 25;44(5):517-21.(PMID: 22446962)
  8. Tremoulet AH, Pancoast P, Franco A, Bujold M, Shimizu C, Onouchi Y, Tamamoto A, Erdem G, Dodd D, Burns JC. Calcineurin inhibitor treatment of IVIG-resistant Kawasaki disease. J. Peds. 2012 Apr 6; 161(3): 506–512.e1.(PMID: 22484354)
  9. Tremoulet AH. Comment on atorvastatin safety in kawasaki disease patients with coronary artery aneurysms. Pediatr. Cardiol. 2014 Jan;35(1):93.(PMID: 24072043)
  10. Tremoulet AH, Jain S, Jaggi P, Jimenez-Fernandez S, Pancheri JM, Sun X, Kanegaye JT, Kovalchin JP, Printz B, Ramilo O, Burns JC. Phase III randomised, double-blind, placebo-controlled trial of infliximab for intensification of primary therapy for Kawasaki disease. Lancet. 17 May 2014;383(9930):1731-1738.(PMID: 24572997)
  11. Tremoulet AH, Le J, Poindexter B, Sullivan JE, Laughon M, Delmore P, Salgado A, Ian UCS, Melloni C, Gao J, Benjamin DK, Jr., Capparelli EV, Cohen-Wolkowiez M. Characterization of the Population Pharmacokinetics of Ampicillin in Neonates Using an Opportunistic Study Design. Antimicrob Agents Chemother. Jun 2014;58(6):3013-3020.(PMID: 24614374)
  12. Tremoulet AH, Dutkowski J, Sato Y, Kanegaye JT, Ling XB, Burns JC, Emergency Medicine Kawasaki Disease Research Group. Novel data-mining approach identifies biomarkers for diagnosis of Kawasaki disease. Peds Research. 2015 Nov;78(5):547-53.(PMID: 26237629)
  13. Jaggi P, Wang W, Dvorchik I, Printz B, Berry E, Kovalchin JP, Texter K, Ramilo O, Burns JC, Tremoulet AH. Patterns of Fever in Children After Primary Treatment for Kawasaki Disease. Pediatr. Infect. Dis. J. 2015 Dec;34(12):1315-8.(PMID: 26353031)
  14. Tremoulet AH, Jain S, Kim S, Newburger J, Arditi M, Franco A, Best B, Burns JC. Rationale and study design for a phase I/IIa trial of anakinra in children with Kawasaki disease and early coronary artery abnormalities (the ANAKID trial). Contemp Clin Trials. 2016 May;48:70-5.(PMID: 27080929)
  15. Doan S, Maehara CK, Chaparro JD, Lu S, Liu R, Graham A, Berry E, Hsu CN, Kanegaye JT, Lloyd DD, Ohno-Machado L, Burns JC, Tremoulet AH, Pediatric Emergency Medicine Kawasaki Disease Research G. Building a Natural Language Processing Tool to Identify Patients with High Clinical Suspicion for Kawasaki Disease from Emergency Department Notes. Acad. Emerg. Med. 2016 May;23(5):628-36.(PMID: 26826020)
  16. Herberg JA, Kaforou M, Wright VJ, Shailes H, Eleftherohorinou H, Hoggart Clive, Cebey-López M, Carter M, Janes V, Gormley S, Shimizu C, Tremoulet AH, Barendregt A, Salas A, Kanegaye J, Pollard A, Faust S, Patel S, Kuijpers T, Martinón-Torres F, Burns J, Coin L, Levin M. Diagnostic Test Accuracy of a 2-Transcript Host RNA Signature for Discriminating Bacterial vs Viral Infection in Febrile Children. JAMA. 2016 Aug 23-30;316(8):835-845.(PMID: 27552617)
  17. Friedman KG, Gauvreau K, Hamaoko-Okamoto A, Tang A, Berry E, Tremoulet AH, Mahavadi VS, Baker A, deFerranti SD, Fulton DR, Burns JC, Newburger JW. Coronary Artery Aneurysms in Kawasaki Disease: Risk Factors for Progressive Disease and Adverse Cardiac Events in US Population. J Am Heart Assoc. 2016 Sep 15;5(9).(PMID:27633390)
  18. Lee AM, Burns JC, Tremoulet AH. Safety of Infliximab Following Live Virus Vaccination in Kawasaki Disease. Ped Inf Dis J. 2016 Dec 1;120(2):354-365.(PMID: 27918378)
  19.  Wright VJ, Herberg JA, Kaforou M, Eleftherohorinou J, Shimizu C, Shailes H Barendregt AM, Tremoulet AH, Kanegaye JT, Coin LJM, Glode MP, Hibberd M, Kuijpers T, Hoggart C, Burns JC, Levin M. Diagnosis of Kawasaki disease using a Minimal Whole-Blood Gene Expression Signature. JAMA Pediatr. 2018 Aug 6: :e182293. doi: 10.1001/jamapediatrics.2018.2293. [Epub ahead of print] (PMID: 30083721)
  20. de Ferranti SD, Gauvreau K, Friedman KG, Tang A, Baker AL, Fulton DR, Tremoulet AH, Burns JC, Newburger JW. Association of Initially Normal Coronary Arteries with Normal Findings on Follow-Up Echocardiography in Patients with Kawasaki Disease. JAMA Pediatr. 2018 Oct 1:e183310 (PMID: 30285057)


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