Clinical Research Activities

Children’s Oncology Group (COG), a National Cancer Institute (NCI) supported clinical trials group, is the world’s largest organization devoted exclusively to pediatric cancer research.[1] The COG conducts a spectrum of clinical research and translational research trials for infants, children, adolescents, and young adults with cancer. UCSD/RCHSD PI: William Roberts, MD

Neuroblastoma and Medulloblastoma Translational Research Consortium (NMTRC) is a group of 18 universities and children's hospitals that offer a nationwide network of childhood cancer clinical trials. These trials are based on the research from a group of closely collaborating investigators who are linked with laboratory programs developing novel therapies for high-risk Neuroblastoma and Medulloblastoma. Our mission is to create a national collaborative effort of researchers and oncologists to bring forward new therapies for children with relapsed Neuroblastoma and Medulloblastoma with the goal of finding a cure for these patients. UCSD/RCHSD PI: William Roberts, MD

Pacific Pediatric Neuro-Oncology Consortium (PNOC) is a network of eight children’s hospitals that conduct clinical trials of new therapies for children with brain tumors. Our goal is to improve outcomes by translating the latest findings in cancer biology into better treatments for these children. At PNOC, our focus is personalized medicine – testing new therapies that are specific to the biology of each patient’s tumor to maximize their effectiveness. Our goal is to improve overall outcome for children with brain tumors. UCSD/RCHSD PI: John Crawford, MD, MS

Pediatric Blood and Marrow Transplant Consortium (PBMTC) is the largest clinical trials group focused exclusively on blood and marrow transplants for children and adolescents. Our consortium includes more than 100 pediatric BMT centers in the United States, Canada, New Zealand, and Australia. PBMTC is a core member of the NIH-funded Blood and Marrow Transplant (BMT) Clinical Trials Network (CTN) and has a close collaborative relationship with the Children's Oncology Group (COG). The PBMTC has clinical trials activities focused on the application of BMT for younger patients and works in concert with many of our industrial partners. As the largest forum focused on pediatric BMT, the PBMTC is committed to research that improves clinical outcomes of BMT in children and adolescents. By vigorously advocating for our patients and their families, we strive to increase awareness and resources for all of those who must undergo this life saving treatment. UCSD/RCHSD PI: Eric Anderson, MD

St. Jude Children’s Research Hospital/Rady Children’s Hospital/UCSD Alliance. This unique alliance is designed to benefit both patient care and research efforts. It enables St. Jude, Rady Children’s, and UCSD to combine their resources and expertise to pursue clinical trials and basic and translational research. UCSD/RCHSD PIs: Deborah Schiff, MD and Donald Durden, MD, PhD

California Childhood Leukemia Study (CCLS). This study is a case-control study investigating the causes of childhood leukemia in California. The overall purpose of this epidemiologic study is to find specific genetic or environmental factors that may increase the risk of leukemia in children. The study is being conducted by Patricia Buffler, PhD at the School of Public Health - University of California Berkeley in collaboration with the California Department of Health Services and 16 hospitals located throughout the state of California. The study began in 1995 and will continue to 2014. UCSD/RCHSD PI: William Roberts, MD