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Allergy, Immunology and Rheumatology
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Seema S. Aceves, MD, PhD
Understand the mechanisms of TGFb1 effects on smooth muscle contraction in EoE
Conduct studies to elucidate a gene-environment interaction between food and TGFb1
Find new biomarkers in EoE
Understand the effects of mepolizumab on esophageal remodeling in EoE
Continue to expand the EGID clinic
Help to develop and design multi-center , NIH funded clinical trials in collaboration with The International Gastrointestinal Researchers and the Registry for Eosinophilic Gastrointestinal Disorder
Participate in trials that validate pediatric quality of life and symptom activity indexes in EoE
John F. Bastian, MD
Retiring in the coming year
Establish policies and protocols to provide quality and efficient clinical care
Jane C. Burns, MD. and Chisato Shimizu, MD
Define panel of protein biomarkers as a diagnostic test for KD
Complete family-based linkage analysis
Define role of microRNAs in KD pathogenesis
Devise new therapies to prevent progression of coronary artery damage
Understand mechanisms of action of IVIG
Johanna Chang, MD
Establish clinical and research protocols and procedures for pediatric joint ultrasound
Assume additional leadership roles following the retirement of Dr. Szer
Alessandra I. Franco, MD, PhD
Better characterize the events involved in the cross-talk between B cells and dendritic cells, aiming at the optimization of cytotoxic T cell priming in vivo.
Define a panel of carbohydrate-peptide conjugate that binds with high affinity to MHC class I molecules and has an appropriate structure to induce a T cell response skewed toward the recognition of the sugar moiety.
Explore (and compare) TACA conjugation natural viral sequences, sequences derived from environmental pathogens as the flu viruses and known cancer epitopes (i.e., MUC1 peptides, etc.) in preparation for pre-clinical trials.
Complete studies on T-cell activation in Kawasaki disease.
Hal M. Hoffman, MD
Continue focus on cryopyrin function using a number of novel mouse models designed to reproduce human disease in mice.
Continue to study the mechanism of cold-induced inflammation using cell lines, human monocytes and mice.
Study the role of cryopyrin in more common diseases such as gout, rheumatoid arthritis, infection, otitis, and asthma by collaborating with other UCSD investigators.
Continue to identify families with rare inherited human diseases and search for the genetic basis of these disorders.
Continue to evaluate pediatric patients with allergic and immunologic disease (approximately 400 patients a year).
Pursue clinical interest in autoinflammatory diseases, including the periodic fever disorders, and expand clinic to meet the needs of these patients.
Anthony A. Horner, MD
Continue clinical and teaching responsibilities
Continue research focusing on characterizing the cellular and molecular basis for the Th2 adjuvant and tolerogenic activities of house dust extracts (HDEs)
Continue translational research studies to determine if HDE bioactivity measures predict allergic and respiratory status in clinical practice HDEs
Continue collaborative studies to better understand the molecular basis for the immunostimulatory activities of HDEs
Continue collaborative studies with Genalyte to develop a new generation assay for the characterization and quantification of peanut specific IgE from allergic patients
Seek new sources of funding for our research
Karin Peterson, MD, PhD
Establish protocols for quality and safety in clinics .
Robert M. Sheets, MD
Consolidate practice in San Diego.
Continue involvement in the local Arthritis Foundation branch and its activities for children.
Ilona S. Szer, MD
Retiring in October 2013
To accomplish the Second Edition of Arthritis in Children and Adolescents
Continue to deliver the highest quality of care to children with RD in SD and surrounding catchment area
Continue to work with the Search Committee for a Section Chief of Rheumatology and Sr. Scientist
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