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Publications

  1. Lin JH, Saito T, Anderson DJ, Lance-Jones C, Jessell TM, Arber S.  1998.  Functionally related motor neuron pool and muscle sensory afferent subtypes defined by coordinate expression ETS gene expression.  Cell.  95:393-407. PMID: 9814709.
  2. Arber S, Ladel DR, Lin JH, Frank E, Jessell TM.  2000.  ETS gene Er81 controls the formation   of functional connections between group Ia sensory afferents and motor neurons. Cell. 101:485-498. PMID: 10850491.
  3. Lin JH, Li H, Yasumura D, Cohen HR, Zhang C, Panning B, Shokat KM, LaVail MM, Walter P. IRE1 signaling affects cell fate during the unfolded protein response.  2007.  Science. 318:944-949.  PMID: 17991856.
  4. Lin JH, Walter P, Yen, TSB. 2008. Endoplasmic reticulum stress in disease pathogenesis.  Ann Rev Pathol. 3:399-425. PMID: 18039139.
  5. Lisbona F, Rojas-Rivera D, Thielen P, Zamorano S, Todd D, Martinon F, Glavic A, Kress C, Lin JH, Walter P, Reed JC, Glimcher LH, Hetz C.  2009.  BAX Inhibitor-1 is a negative regulator of the ER stress sensor IRE1a.  Molecular Cell.  33: 679-691. doi: 10.1016/j.molcel.2009.02.017. PMID: 19328063.
  6. Lin JH, Li H, Zhang Y, Ron D, Walter P. 2009.  Divergent effects of PERK and IRE1 signaling on cell viability.  PLoS ONE.  4(1): e4170. doi: 10.1371/journal.pone.0004170. Epub 2009 Jan 12. PMID:19137072.
  7. Hollien J, Lin JH, Li H, Stevens N, Walter P, Weissman JS.  2009.  Regulated Ire1-dependent decay of mRNAs in mammalian cells. J Cell Biol. 186(3): 326-331. doi: 10.1083/jcb.200903014. Epub 2009 Aug 3. PMID:19651891.
  8. Gorbatyuk MS, Knox T, LaVail MM, Gorbatyuk OS, Noorwez SM, Hauswirth WW, Lin JH, Muzycska N, Lewin AS.  2010. Restoration of visual function in P23H transgenic rats by gene delivery of BiP/Grp78.  PNAS. 107(13): 5961-5966. doi: 10.1073/pnas.0911991107. Epub 2010 Mar 15. PMID:20231467.
  9. Mahajan VB, Vallone J, Lin JH, Mullins RF, Ko AC, Folk JC, Stone EM.  2010.  T-cell infiltration in autosomal dominant neovascular vitreoretinopathy. Mol Vis. 16(114-115):1034-1040. PMID: 20596252
  10. Lin JH, LaVail MM. 2010. Misfolded proteins and retinal dystrophies.  Adv Exp Med Biol. 664:115-121. doi: 10.1007/978-1-4419-1399-9_14. PMID: 20238009.
  11. Vasireddy V, Chavati VRM, Joseph VT, Kadam R, Lin JH, Jamison JA, Kompella UB, Gereddy B, Ayyagari R.  2011.  Rescue of photoreceptor degeneration by curcumin in transgenic rats with P23H rhodopsin mutation. PLoS ONE.  6(6): e21193. doi: 10.1371/journal.pone.0021193. Epub 2011 Jun 29. PMID: 21738619.
  12. Hiramatsu N, Joseph VT, Lin JH. 2011. Monitoring and manipulating the mammalian unfolded protein response.  Methods Enzymol. 491C:183-198. doi: 10.1016/B978-0-12-385928-0.00011-0. PMID: 21329801.
  13. Mantuano E, Henry K, Yamauchi T, Hiramatsu N, Yamauchi K, Orita S, Takahashi K, Lin JH, Gonias SL, Campana WM.  2011.  Inhibiting the Unfolded Protein Response is a major mechanism by which LRP1 promotes Schwann cell survival.  J Neurosci. 31(38): 13376-13385. doi: 10.1523/JNEUROSCI.2850-11.2011. PMID: 21940431.
  14. Chiang WC, Messah C, Lin JH.  2012.  IRE1 directs proteasomal and lysosomal degradation of misfolded rhodopsin. Mol Biol Cell. 23(5): 758-770. doi: 10.1091/mbc.E11-08-0663. Epub 2012 Jan 4. PMID:  22219383.
  15. Gorbatyuk MS, Gorbatyuk OS, LaVail MM, Lin JH, Hauswirth WW, Lewin AS.  2012. Functional rescue of P23H rhodopsin photoreceptors by gene delivery.  Adv Exp Med Biol.  723:191-197. doi: 10.1007/978-1-4614-0631-0_26. PMID: 22183333.
  16. Chiang WC, Hiramatsu N, Messah C, Lin JH.  2012.  Selective activation of ATF6 and PERK signaling pathways prevent mutant rhodopsin accumulation.  Invest Ophthal Vis Sci. 53(11): 7159-7166. doi: 10.1167/iovs.12-10222. PMID: 22956602.
  17. Gorbatyuk MS, Shabashvili A, Chen W, Meyers C, Sullivan LF, Lin JH, Lewin AS, Muzyczka N, Gorbatyuk OS.  2012. Glucose regulated protein 78 (GRP78/BiP) diminishes a-synuclein  neurotoxicity in a rat model of Parkinson Disease.  Mol Therapy. Jul;20(7):1327-37. doi: 10.1038/mt.2012.28. Epub 2012 Mar 20.PMID: 22434142.
  18. Kroeger H, Chiang WC, Lin JH. 2012. Endoplasmic reticulum associated degradation (ERAD) of mutant P23H rhodopsin in photoreceptors.  Adv Exp Med Biol. 723:559-565. doi: 10.1007/978-1-4614-0631-0_71. Review. PMID: 22183378.
  19. Shinde V, Sizova OS, Lin JH, LaVail MM, Gorbatyuk MS.  2012.  ER stress in retinal  degeneration in S334ter rhodopsin rats.  PLoS ONE. 7(3): e33266.  doi: 10.1371/journal.pone.0033266. Epub 2012 Mar 14.PMID: 22432009.
  20. Kroeger H, Messah C, Ahern K, Gee J, Joseph V, Matthes MT, Yasumura D, Gorbatyuk MS, Chiang WC, LaVail MM, Lin JH.  2012.  Induction of endoplasmic reticulum stress genes, BiP and Chop, in genetic and environmental models of retinal degeneration. Invest Ophthal Vis Sci. 53(12): 7590-7599. doi: 10.1167/iovs.12-10221. PMID: 23074209
  21. Hodgson N, Whipple K, Lin JH, Brumund K, Kikkawa DO, Korn BS. 2013. Bilateral squamous cell carcinoma of the lacrimal sac. Ophthal Plast Reconstr Surg.  29(6):e149-151. doi: 10.1097/IOP.0b013e3182831c2d. PMID: 24217491.
  22. Muller KA, Lin JH.  2014.  Orbital granulomatosis with polyangiitis (Wegener Granulomatosis).     Arch Path     Lab Med. 138:1110–1114; doi:10.5858/arpa.2013-0006-RS.  PMID:  25076302.
  23. Joshi-Barr S, Bett C, Chiang WC, Trejo M, Goebel HH, Sikorska B, Liberski P, Raeber A, Lin JH, Masliah E, Sigurdson CJ. 2014. De novo prion aggregates trigger autophagy in skeletal muscle. 88(4): 2071-82.  doi: 10.1128/JVI.02279-13. Epub 2013 Dec 4.PMID: 24307586
  24. Kroeger H, LaVail, MM, Lin JH. 2014. Endoplasmic reticulum stress in vertebrate mutant rhodopsin models of retinal degeneration.  Adv Exp Med Biol. 801:585-592.  doi: 10.1007/978-1-4614-3209-8_74. PMID: 24664747.
  25. Hiramatsu N, Messah C, Han J, LaVail MM, Kaufman RJ, Lin JH. 2014. Translational and post-translational regulation of XIAP by eIF2a and ATF4 promotes endoplasmic reticulum stress-induced cell death during the Unfolded Protein Response. Mol Biol Cell. May; 25(8): 1411-1420. doi: 10.1091/mbc.E13-11-0664. Epub 2014 Mar 12. PMID:  24623724.
  26. Mahajan VB, Lin JH.  2013.  Leukocyte infiltration in CAPN5 autosomal dominant neovascular inflammatory vitreoretinopathy.  Clin Ophthalmol. 7:1-7.  doi: 10.2147/OPTH.S46450. Epub 2013 Jul 3. PMID: 23861576.
  27. Wert KJ, Lin JH, Tsang SH.  2014.  General pathophysiology in retinal degeneration.  Dev Ophthalmol.  53:33-43.  doi: 10.1159/000357294. Epub 2014 Apr 10. Review. PMID: 24732759.
  28. Chiang WC, Kroeger H, Sakami S, Messah C, Yasumura D, Matthes MT, Coppinger JA, Palczewski K, LaVail MM, Lin JH.  2014.  Robust endoplasmic reticulum-associated degradation of rhodopsin precedes retinal degeneration.  Mol Neurobiol. Epub 2014 Oct 2. DOI:10.1007/s12035-014-8881-8. PMID: 25270370
  29. Chiang WC, Lin JH. 2014. Effects of IRE1, ATF6, and PERK signaling on adRP-linked rhodopsins.  Adv Exp Med Biol. 801: 661-667. doi: 10.1007/978-1-4614-3209-8_83. PMID: 24664756.
  30. Ouyang H, Xue Y, Lin Y, Zhang X, Xi L, Patel S, Cai H, Luo J, Zhang M, Zhang M, Yang Y, Li G, Li H, Jiang W, Weh E, Lin JH, Pei M, Zhu J, Cao G, Zhang L, Yu B, Chen S, Fu XD, Liu Y, Zhang K. 2014. WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesis.  Nature.  511(7509):358-361. doi: 10.1038/nature13465. Epub 2014 Jul 2.  PMID: 25030175.
  31. Karam R, Lou CH, Kroeger H, Huang L, Lin JH, Wilkinson MF. The Unfolded Protein Response is shaped by the NMD pathway. EMBO Reports.  2015. doi: 10.15252/embr.201439696.Published online 25.03.2015.  Pubmed PMID: 25807986. 
  32. Hiramatsu N, Chiang WC, Kurt TD, Sigurdson CJ, Lin JH. 2015.  Multiple mechanisms of Unfolded Protein Response-induced cell death. Am J Pathol. 185(7): 1800-1808.  doi: 10.1016/j.ajpath.2015.03.009. Epub 2015 May 5. PMID: 25956028.
  33. Salganik M, Sergeyev VG, Meyers CA, Shinde V, Gorbatyuk MS, Lin JH, Zolotukhin S, Gorbatyuk OS. 2015. Loss of Glucose Regulated Protein 78 (GRP78) during normal aging or from siRNA knockdown augments human alpha-Synuclein toxicity to rat nigral neurons. Neurobiol Aging. Epub 2015 Mar 5 doi: 10.1016/j.neurobiolaging.2015.02.018. PMID:25863526
  34. Zou AE, Ku J, Honda TK, Yu V, Kuo SZ, Zheng H, Xuan Y, Hinton A, Brumund KT, Lin JH, Wang-Rodriguez J, Ongkeko WM.  2015.  Transcriptome sequencing uncovers novel long non-coding and small nucleolar RNAs dysregulated in head and neck squamous cell carcinoma.  RNA. 2015 Jun;21(6):1122-34. doi: 10.1261/rna.049262.114. Epub 2015 Apr 22.  PMID:25904139.
  35. Kohl S, Zobor D, Chiang W, Weisschuh N, Staller J, Gonzalez Menendez I, Chang S, Beck SC, Garcia Garrido M, Sothilingam V, Seeliger MW, Stanzial  F, Benedicenti F, Inzana F, Héon E, Vincent A, Beis J, Strom TM, Rudolph G, Roosing S, den Hollander AI, Cremers F, Lopez I, Ren H, Moore AT, Webster A, Michaelides M, Koenekoop RK, Zrenner E, Kaufman RJ, Tsang SH, Wissinger B, Lin JH.  2015.  Mutations in the Unfolded Protein Response regulator, ATF6, cause the cone dysfunction syndrome Achromatopsia.  Nat Genet. 2015. 47:757-765. Jun 1. doi: 10.1038/ng.3319.