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Fisch Lab

Translating genomic discoveries to improve mother and child health throughout the lifespan.

​Dr. Kathleen Fisch

Kathleen Fisch, Ph.D. is an Assistant Professor in the Department of Obstetrics, Gynecology and Reproductive Sciences, in the Division of Maternal-Fetal Medicine.  She serves as the Faculty Director of the UC San Diego Center for Computational Biology & Bioinformatics (CCBB) and as the Co-Director of the ACTRI Center for Excellence in Translational Immunogenomics (CETI). Dr. Fisch spearheads the development of a vibrant, leading edge vision for computational genomics, bioinformatics support and infrastructure at UCSD Health Sciences.  

Full Biography

​About the Lab

Our group focuses on understanding the molecular mechanisms underlying pregnancy disorders and exposures to improve maternal and child health throughout the lifespan.

​Selected Publications

A convergent molecular network underlying autism and congenital heart disease. Cell Syst. 2021 Aug 13. Rosenthal SB, Willsey HR, Xu Y, Mei Y, Dea J, Wang S, Curtis C, Sempou E, Khokha MK, Chi NC, Willsey AJ,Fisch KM, Ideker T. PMID: 34411509.

Inflammation-driven deaminase deregulation fuels human pre-leukemia stem cell evolution. Cell Rep. 2021 01 26; 34(4):108670. Jiang Q, Isquith J, Ladel L, Mark A, Holm F, Mason C, He Y, Mondala P, Oliver I, Pham J, Ma W, Reynoso E, Ali S, Morris IJ, Diep R, Nasamran C, Xu G, Sasik R, Rosenthal SB, Birmingham A, Coso S, Pineda G, Crews L, Donohoe ME, Venter JC, Whisenant T, Mesa RA, Alexandrov LB,Fisch KM, Jamieson C. PMID: 33503434.

Post Doctoral Position Available!

A postdoctoral position is available in the laboratory of Dr. Kathleen Fisch in the UC San Diego School of Medicine Department of Obstetrics, Gynecology & Reproductive Sciences, Division of Maternal-Fetal Medicine, part of the newly established Center for Perinatal Discovery. The lab focuses on the application of genomics to discover biomarkers that can predict pregnancy disorders and adverse fetal outcomes in order to improve maternal-fetal health. The candidate will be supported by NIH awards and will be involved in the following research initiatives:

  • Analysis of human placenta sequencing data (e.g. scRNAseq, scATACseq, spatial transcriptomics) as a member of the HuBMAP Female Reproductive Tissue Mapping Center (
  • Design and analysis of clinical research studies involving technologies such as single cell and bulk transcriptomics, epigenomics, genomics, proteomics and metabolomics.
  • Analysis of extracellular RNA and genomics data in the context of chronic pain as a member of the A2CPS Consortium (

This position affords ample opportunity for academic growth, multi-institutional and multi-disciplinary collaborations. The successful candidate will be encouraged to explore new research areas and seek independent funding to establish a pathway for independence. The ideal candidate will be expected to draft manuscripts and present results at professional meetings. Candidates are required to have a Ph.D. or M.D./Ph.D. in molecular and cellular biology or a related discipline with an emphasis on clinical research, reproductive science, epidemiology, or molecular biology. The ideal candidate will have a strong background in molecular biology with excellent quantitative analytical skills and familiarity with next generation sequencing technologies and lab protocols.

Applicants are expected to be within two years of completing graduate studies and have a strong publication record with excellent writing and communication skills. Experience with the R programming language is preferred. While computational skills are desirable, highly motivated candidates aspiring to acquire these skills will be considered and training will be provided.

If interested, please email a cover letter summarizing current research and career goals, curriculum vitae, and list of three references to Dr. Kathleen Fisch.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran. The Office of Research Affairs at UC San Diego is committed to academic excellence and diversity within the academic, staff, and student body. Salary is commensurate with qualifications and based on published University of California pay scales