Program Director: Antoni Duleba, MD
This fellowship training program is designed to qualify individuals for the subspecialty board in reproductive endocrinology. The goal of this training program is to provide fellows with a balance of training between clinical and research activities and to prepare them for an academic career with a solid foundation for leadership in reproductive endocrinology.
The clinical and research activities of the Division of Reproductive Endocrinology and Infertility are conducted by faculty members composed of basic scientists, clinicians, and clinical investigators. This cohesive group of faculty members provides a conducive academic environment to pursue high quality and contemporary training. The faculty preceptors and their expertise are listed below:
Antoni Duleba, MD - Professor, Reproductive Medicine, Chief of the Division of Reproductive Endocrinology and Infertility, and Director of Reproductive Endocrinology and Infertility Fellowship Training, UCSD.
Ovarian dysfunction, endometriosis, and infertility.
H. Irene Su, MD, MSCE - Assistant Professor, Reproductive Medicine, Division of Reproductive Endocrinology and Infertility, UCSD.
Preservation of fertility in women with cancer.
Sanjay K. Agarwal, M.D -Professor, Reproductive Medicine, Division of Reproductive Endocrinology and Infertility, UCSD.
Infertility and Endometriosis.
Heidi Cook-Andersen, MD, PhD - Assistant Professor, Reproductive Medicine, Division of Reproductive Endocrinology and Infertility, UCSD.
Post-transcriptional regulation of maternal mRNA during early mammalian embryogenesis.
R. Jeffrey Chang, MD - Professor Emeritus, Reproductive Medicine, UCSD.
Reproductive metabolic processes in ovarian disorders.
Pamela Mellon, PhD - Professor and Vice-Chair for Research, Reproductive Medicine and Neurosciences, Division of Reproductive Endocrinology and Infertility, UCSD. Director of the NICHD Center for Reproductive Science and Medicine and the NIH Training Program in Reproductive Sciences.
Regulation and development of the reproductive neuroendocrine system.
Shimasaki, Shunichi, MSc, PhD - Professor, Reproductive Medicine, Division of Reproductive Endocrinology and Infertility, UCSD.
Molecular mechanism of growth factor control in folliculogenesis.
Lawson, Mark, PhD - Professor, Reproductive Medicine, Division of Reproductive Endocrinology and Infertility, UCSD.
Mechanisms of reproductive hormone and regulation of gene expression in the gonadotrope.
Kauffman, Alexander, PhD - Assistant Professor, Reproductive Medicine, Division of Reproductive Endocrinology and Infertility, UCSD.
Neuroendocrine control of puberty and reproductive function.
Wilkinson, Miles, PhD - Professor, Reproductive Medicine, Division of Reproductive Endocrinology and Infertility, UCSD.
Transcriptional and RNA regulatory mechanisms impacting mammalian fertility, neurological function, and cancer.
Thackray, Varykina, PhD - Assistant Professor, Reproductive Medicine, Division of Reproductive Endocrinology and Infertility, UCSD.
Role of transcription factors in gonadotrope cells.
Church, Kellie, PhD - Assistant Professor, Reproductive Medicine, Division of Reproductive Endocrinology and Infertility, UCSD.
Physiologic interactions between the stress and reproductive axes.
Michael Hsieh, MD - Assistant Clinical Professor, Urology, UCSD.
Mechanisms of testicular development and markers of sperm function.
- David Meldrum, MD - Reproductive Partners-UCSD Regional Fertility Center; Clinical Professor, Reproductive Medicine, Division of Reproductive Endocrinology and Infertility, UCSD
- Gabriel Garzo, MD - Reproductive Partners-UCSD Regional Fertility Center; Clinical Professor, Reproductive Medicine, Division of Reproductive Endocrinology and Infertility, UCSD
- Michael Wittenberger, MD - Naval Medical Center San Diego
- Li-Shei Lin, MD - Kaiser Permanente San Diego; Clinical Professor, Reproductive Medicine, Division of Reproductive Endocrinology and Infertility, UCSD
- Patricia Wu, MD - Kaiser Permanente San Diego
- Richard Yoo, MD - Kaiser Permanente San Diego
- Michael Gottschalk, MD - Clinical Professor, Pediatrics, Chief, Division of Pediatric Endocrinology and Infertility, UCSD and Rady Children’s Hospital San Diego
Structure and Rotations
Each fellow will rotate through medical (3 months) and pediatric (3 months) endocrine clinics. Fellows are encouraged to attend the Reproductive Medicine Departmental Grand Rounds scheduled on Wednesday afternoons as well as seminars and conferences provided by other departments and institutions (i.e. Department of Medicine, Neuroscience, Biology, Salk Institute). Also, fellows participate in night call rotation in obstetrics and gynecology.
Fellows actively participate in the evaluation, management, and follow-up of patient care with special emphasis toward the comprehensive understanding of reproductive disorders and infertility processes. Acquisition of knowledge and techniques in Assisted Reproductive Technologies (ART, by rotation at noted institutions), endoscopy, and microsurgery are integrated segments of our training program. Clinical activities are concentrated in the first tow years of training as the third year focuses on completion of research projects. Diverse reproductive disorders are managed by the faculty with increasing responsibility by the fellows. Fellows are expected to be highly versed with policies and procedures of the Clinical Research Center in order to delineate the pathophysiology of complex clinical problems.
Clinics: Throughout the year fellows will participate in the evaluation and management of patients with reproductive disorders under the supervision of the full-time clinical faculty within the Division of Reproductive Endocrinology. During one three month interval they attend medical endocrine and pediatric endocrine clinics once a week. They will also receive training in andrology and male infertility. Fellows maintain the Ovulation Induction Clinic, which will allow them to follow through the evaluation, treatment and the final outcome of their patients.
Surgery: Under the supervision of clinical faculty fellows are responsible for a variety of surgical procedures and related patient care activities. They will be involved in the surgical management of patients which are seen during the course of the year with full-time clinical faculty as well as those seen in their own clinic. During a six months interval fellows will attend and participate in the surgical management of patients seen at the Kaiser Reproductive Endocrinology and Infertility Clinics and at the Naval Medical Center San Diego.
Assisted Reproductive Technology: Fellows will receive training in the specialized field of ART at the Reproductive Partners- UCSD Regional Fertility Center for four months. They will be supervised by clinical faculty in learning the principles of gamete physiology and acquiring the techniques of a variety of procedures including IVF, GIFT, and current micromanipulative methodologies.
During the ART rotation fellows will receive training in andrology. The fellow is attends a male infertility clinic once a week during this rotation under the supervision of UCSD faculty in urology that see patients at Reproductive Partners-UCSD Regional Fertility Center.
Fellows have the opportunity to participate in undergraduate and/or graduate courses to remedy background deficiencies and to acquire skills important to their career goals. A variety of courses relevant to human reproduction are available at the UCSD School of Medicine as well as the General Campus. The required courses set forth by the American Board of Obstetrics and Gynecology in the subspecialty area of Reproductive Endocrinology must be fulfilled. Among them are Biostatistics, Molecular Biology, Molecular and Cellular Neurobiology, Molecular and Cellular Neuroendocrinology, Neuroscience, Pharmacology and Physiology.
The research component of our training program offers a range of projects with faculty expertise represented in ovarian molecular and cellular biology, gene regulation and expression, endocrine-metabolic regulation, neuroendocrine control mechanisms and biostatistics. Ethics in research and attendance of School of Medicine courses is emphasized. Our research training program is integrated with the activities of the U54 Sepecialized Cooperative Centers Program in Infertility and Reproduction (SCCPIR) funded by NICHD. Functioning in a coordinated fashion and with direct participation by the fellows, our training program offers diverse research opportunities; examples:
- Characterization and regulation of hormone gene expression
- Interrelationship between GnRH, opioidergic and catecholominergic neurons and their modulation by sex steroids, inhibin, activin and follistatin as well as other growth factors.
- Cellular and molecular mechanisms in the regulation of follicular growth and differentiation.
- The role of neuropeptides, growth factors, and inhibin related peptides in intragonadal regulation.
- The use of transgenic mouse models to uncover molecular mechanisms in GnRH and gonadotropin subunit biosynthesis, expression and regulation.
- Neuroendocrine-metabolic control of the human menstrual cycle and its disorders.
- Delineation of pathophysiology of chronic anovulation.
- Ovarian physiology, senescence and menopause.
These research areas as well as others are targeted for an integrated analysis of hypothalamic-pituitary-gonadal-endometrial interactions during puberty, the menstrual cycle, and menopause in rodent models as well as in humans. Clinical disorders will be investigated to answer specific questions. The research component of this program includes didactic teaching, discussion groups, a journal club, seminars, laboratory training molecular biology and clinical investigation. Emphasis is placed on the fundamental design and execution of experiments, methodology, and analysis of data. Our aim is to prepare the physician-scientist with expertise in broad areas of basic and clinical reproductive processes and disorders.
Applicants who have completed their residency training in obstetrics and gynecology are eligible to apply. Prior approval by the American Board of Obstetrics and Gynecology, Subspecialty Division of Reproductive Endocrinology is required. According to University of California policy we are unable to accept applicants in any visa status.
- A letter from the candidate outlining his/her past academic and/or clinical experiences, a statement of his/her long term career goal(s) as well as current interests as related to the training he/she hopes to obtain.
- A curriculum vitae, including a bibliography.
- Two letters of recommendation to be emailed (preferred) to Eunice Tingzon at firstname.lastname@example.org or mailed directly to:
Antoni Duleba, MD
Director, Division of Reproductive Endocrinology
Department of Reproductive Medicine
UCSD School of Medicine
9500 Gilman Drive #0633
La Jolla, CA 92093-0633
If you need further explanation contact Eunice Tingzon, coordinator Fellowship Training Program at (858) 534-8930, Fax (858) 534-8856, or e-mail