Nishant Singhal

Assistant Project Scientist

Contact Information

Phone: 858-822-3669
Email: nisinghal@ucsd.edu

Location:
Cellular and Molecular Medicine, West, room 337

Mailing Address:
9500 Gilman Drive #0649
La Jolla, CA 92093-0649


Nishant Singhal earned his MS in biotechnology from Himachal Pradesh University in Shimla, India, and his PhD in developmental biology from the Adolf Butenandt Institute, Ludwig Maximilians University, Munich, Germany. He was a postdoctoral fellow in the Department of Cell and Developmental Biology at the Max-Planck Institute of Molecular Biomedicine in Muenser, Germany from 2005-2011.

In 2012 he joined the William Mobley Lab at UC San Diego to pursue his research on stem cells and Down syndrome.

Dr. Singhal focuses on utilizing human induced pluripotent cells to model Down syndrome. Human induced pluripotent cells based in an in-vitro model will help us understand the underlying causes of cognition deficit as well as progression of Alzheimer’s disease in individuals with Down syndrome.

Further, molecular biomarkers identified during these studies will be used to generate reporter cell lines. These reporter cells lines will be useful in identifying newer drugs to improve cognition and treat Alzheimer’s disease.

See more about research at our Down Syndrome Center for Research and Treatment.

  1. Singhal, N*., et. al., (2014) Down syndrome stem cell display developmental switch from neural to gliogenic fate (Manuscript under Preparation).
  2. Singhal, N*., et. al., (2014) Brg1 and Baf155 enhances induction of pluripotent cells from adult human fibroblasts. (Manuscript under Preparation).
  3. Singhal, N., Nicetto, D., Wagner, G., Kremmer, E., and Rupp, R.A.W. (2014) BRG1 dependent SWI/SNF chromatin remodeling complex regulates early embryonic patterning. (Development-Under revision).
  4. Rupp, R. A. W., Singhal, N., and Veenstra, G. J. C. (2002). When the embryonic genome flexes its muscles – chromatin and myogenic specification. European Journal of Biochemistry 269, 2294-2299.
  5. Zaehres, H., Do, J.T., Singhal, N., Tapia, N., Han, D.W., and Scholer, H. (2008). Genetic modulation of self-renewal factors for induced reprogramming of somatic cells. Cell Res 18.
  6. Sharma, A.D., Narain, N., Handel, E.M., Iken, M., Singhal, N., Cathomen, T., Manns, M.P., Scholer, H.R., Ott, M., and Cantz, T. (2011). MicroRNA-221 regulates FAS-induced fulminant liver failure. Hepatology 53, 1651-1661.
  7. Singhal, N*., Esch, D., Stehling, M., Scholer, HR. (2014) BRG1is required to maintain pluripotency of murine embryonic stem cells. Bioresearch Open Access, 3, 1-8.
  8. Wu, W., Han, D., Gong, Y., Sebastiano, V., Gentile, L., Singhal, N., Adachi, K., Fischedick, G., Ortmeier, C., Sinn, M., Radstaak, M., Tomilin, A., Schöler, HR (2013) Establishment of Totipotency does not depend on Oct4. Nature Cell Biology, 15, 1089-1097.
  9. Singhal, N., Graumann,J, Wu, G., Bravo, MJA., Han, DW., Greber, B., Gentile, L., Mann, M., and Schöler, HR. (2010). Chromatin Remodeling components of the BAF Complex Facilitate Reprogramming. Cell 141, 943-955.