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Recent Publications

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2023

Zhao Y, Caron C, Chan YY, Lee CK, Xu X, Zhang J, Masubuchi T, Wu C, Bui JD, Hui E. cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8(+) T cell function and anti-tumor immunity. Immunity 2023. Epub 2023/05/10.

Yu Z, Zhang L, Cattaneo P, Guimaraes-Camboa N, Fang X, Gu Y, Peterson KL, Bogomolovas J, Cuitino C, Leone GW, Chen J, Evans SM. Increasing Mononuclear Diploid Cardiomyocytes by Loss of E2F Transcription Factor 7/8 Fails to Improve Cardiac Regeneration After Infarct. Circulation 2023;147(2):1836. Epub 2023/01/10. PMCID: PMC9988404.

Navia-Pelaez JM, Borges Paes Lemes J, Gonzalez L, Delay L, Dos Santos Aggum Capettini L, Lu JW, Goncalves Dos Santos G, Gregus AM, Dougherty PM, Yaksh TL, Miller YI. AIBP regulates TRPV1 activation in chemotherapy-induced peripheral neuropathy by controlling lipid raft dynamics and proximity to TLR4 in dorsal root ganglion neurons. Pain 2023;164(6):e274-e85. Epub 2023/02/01. PMCID: PMC10182209.

Navia-Pelaez JM, Agatisa-Boyle C, Choi SH, Sak Kim Y, Li S, Alekseeva E, Weldy K, Miller YI. Differential Expression of Inflammarafts in Macrophage Foam Cells and in Nonfoamy Macrophages in Atherosclerotic Lesions-Brief Report. Arterioscler Thromb Vasc Biol 2023;43(2):323-9. Epub 2022/12/02. PMCID: PMC9877149.

Marfull-Oromi P, Onishi K, Han X, Yates JR, 3rd, Zou Y. The Fragile X Messenger Ribonucleoprotein 1 Participates in Axon Guidance Mediated by the Wnt/Planar Cell Polarity Pathway. Neuroscience 2023;508:76-86. Epub 2022/10/04.

Liu JJ, Xin B, Du L, Chen L, Long Y, Feng GS. Pharmaceutical SH2 domain-containing protein tyrosine phosphatase 2 inhibition suppresses primary and metastasized liver tumors by provoking hepatic innate immunity. Hepatology 2023;77(5):1512-26. Epub 2022/05/04. PMCID: PMC9948275.

Li W, Wen L, Rathod B, Gingras AC, Ley K, Lee HS. Kindlin2 enables EphB/ephrinB bi-directional signaling to support vascular development. Life Sci Alliance 2023;6(3). Epub 2022/12/28. PMCID: PMC9795039.

Kim H, Saikia J, Monte K, Ha E, Romaus-Sanjurjo D, Sanchez J, Moore A, Hernaiz-Llorens M, ChavezMartinez C, Agba C, Li H, Lusk D, Cervantes K, Zheng B. Probing regenerative heterogeneity of corticospinal neurons with scRNA-Seq. Res Sq 2023. Epub 2023/03/04. PMCID: PMC9980198.

Jin Z, Dridi N, Palui G, Palomo V, Jokerst JV, Dawson PE, Sang QA, Mattoussi H. Quantum Dot-Peptide Conjugates as Energy Transfer Probes for Sensing the Proteolytic Activity of Matrix Metalloproteinase-14. Anal Chem 2023;95(5):2713-22. Epub 2023/01/28.

Jin Z, Dridi N, Palui G, Palomo V, Jokerst JV, Dawson PE, Amy Sang QX, Mattoussi H. Evaluating the Catalytic Efficiency of the Human Membrane-type 1 Matrix Metalloproteinase (MMP-14) Using AuNPPeptide Conjugates. J Am Chem Soc 2023;145(8):4570-82. Epub 2023/02/22.

Chung C, Yang X, Bae T, Vong KI, Mittal S, Donkels C, Westley Phillips H, Li Z, Marsh APL, Breuss MW, Ball LL, Garcia CAB, George RD, Gu J, Xu M, Barrows C, James KN, Stanley V, Nidhiry AS, Khoury S,

Howe G, Riley E, Xu X, Copeland B, Wang Y, Kim SH, Kang HC, Schulze-Bonhage A, Haas CA, Urbach

H, Prinz M, Limbrick DD, Jr., Gurnett CA, Smyth MD, Sattar S, Nespeca M, Gonda DD, Imai K, Takahashi

Y, Chen HH, Tsai JW, Conti V, Guerrini R, Devinsky O, Silva WA, Jr., Machado HR, Mathern GW, Abyzov

A, Baldassari S, Baulac S, Focal Cortical Dysplasia Neurogenetics C, Brain Somatic Mosaicism N, Gleeson JG. Comprehensive multi-omic profiling of somatic mutations in malformations of cortical development. Nat Genet 2023;55(2):209-20. Epub 2023/01/13. PMCID: PMC9961399.

 

2022

Lin L, Pinto A, Wang L, Fukatsu K, Yin Y, Bamforth SD, Bronner ME, Evans SM, Nie S, Anderson RH, Terskikh AV, Grossfeld PD. ETS1 loss in mice impairs cardiac outflow tract septation via a cell migration defect autonomous to the neural crest. Hum Mol Genet. 2022 Dec 16;31(24):4217-4227. doi: 10.1093/hmg/ddac174. PubMed PMID: 35899771.

McCurdy S, Lin J, Shenkar R, Moore T, Lightle R, Faurobert E, Lopez-Ramirez MA, Awad I, Ginsberg MH. β1 integrin monoclonal antibody treatment ameliorates cerebral cavernous malformations. FASEB J. 2022 Dec;36(12):e22629. doi: 10.1096/fj.202200907RR. PubMed PMID: 36349990; PubMed Central PMCID: PMC9674378.

Ramms B, Pollow DP, Zhu H, Nora C, Harrington AR, Omar I, Gordts PLSM, Wortham M, Sander M. Systemic LSD1 Inhibition Prevents Aberrant Remodeling of Metabolism in Obesity. Diabetes. 2022 Dec 1;71(12):2513-2529. doi: 10.2337/db21-1131. PubMed PMID: 36162056; PubMed Central PMCID: PMC9750949.

Geoffroy CG, Meves JM, Kim HJM, Romaus-Sanjurjo D, Sutherland TC, Li JJ, Suen J, Sanchez JJ, Zheng B. Targeting PTEN but not SOCS3 resists an age-dependent decline in promoting axon sprouting. iScience. 2022 Nov18;25(11):105383. doi: 10.1016/j.isci.2022.105383. eCollection 2022 Nov 18. PubMed PMID: 36339257; PubMed Central PMCID: PMC9626739.

Aung A, Davey SK, Theprungsirikul J, Kumar V, Varghese S. Deciphering the Mechanics of Cancer Spheroid Growth in 3D Environments through Microfluidics Driven Mechanical Actuation. Adv Healthc Mater. 2022 Nov 14;:e2201842. doi: 10.1002/adhm.202201842. [Epub ahead of print] PubMed PMID: 36377350.

Gerner RR, Hossain S, Sargun A, Siada K, Norton GJ, Zheng T, Neumann W, Nuccio SP, Nolan EM, Raffatellu M. Siderophore Immunization Restricted Colonization of Adherent-Invasive Escherichia coli and Ameliorated Experimental Colitis. mBio. 2022 Oct 26;13(5):e0218422. doi: 10.1128/mbio.02184-22. Epub 2022 Sep 12. PubMed PMID: 36094114; PubMed Central PMCID: PMC9600343.

Su H, Yang F, Fu R, Trinh B, Sun N, Liu J, Kumar A, Baglieri J, Siruno J, Le M, Li Y, Dozier S, Nair A, Filliol A, Sinchai N, Rosenthal SB, Santini J, Metallo CM, Molina A, Schwabe RF, Lowy AM, Brenner D, Sun B, Karin M. Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. Nature. 2022 Oct;610(7931):366-372. doi: 10.1038/s41586-022-05169-z. Epub 2022 Oct 5. PubMed PMID: 36198801; PubMed Central PMCID: PMC9588640.

Holland ND, Holland LZ, Somorjai IML. Three-dimensional fine structure of fibroblasts and other mesodermally derived tissues in the dermis of adults of the Bahamas lancelet (Chordata, Cephalohordata), as seen by serial block-face scanning electron microscopy. J Morphol. 2022 Oct;283(10):1289-1298. doi: 10.1002/jmor.21502. Epub 2022 Aug 15. PubMed PMID: 35971624.

Ojeda-Juárez D, Lawrence JA, Soldau K, Pizzo DP, Wheeler E, Aguilar-Calvo P, Khuu H, Chen J, Malik A, Funk G, Nam P, Sanchez H, Geschwind MD, Wu C, Yeo GW, Chen X, Patrick GN, Sigurdson CJ. Prions induce an early Arc response and a subsequent reduction in mGluR5 in the hippocampus. Neurobiol Dis. 2022 Oct 1;172:105834. doi: 10.1016/j.nbd.2022.105834. Epub 2022 Jul 26. PubMed PMID: 35905927; PubMed Central PMCID: PMC10080886.

Weeks R, Zhou X, Yuan TL, Zhang J. Fluorescent Biosensor for Measuring Ras Activity in Living Cells. J Am Chem Soc. 2022 Sep 28;144(38):17432-17440. doi: 10.1021/jacs.2c05203. Epub 2022 Sep 19. PubMed PMID: 36122391; PubMed Central PMCID: PMC10031818. Romaus-Sanjurjo D, Saikia JM, Kim HJ, Tsai KM, Le GQ, Zheng B. Overexpressing eukaryotic elongation factor 1 alpha (eEF1A) proteins to promote corticospinal axon repair after injury. Cell Death Discov. 2022 Sep 20;8(1):390. doi: 10.1038/s41420-022-01186-z. PubMed PMID: 36123349; PubMed Central PMCID: PMC9485247.

Barr J, Gentile ME, Lee S, Kotas ME, Fernanda de Mello Costa M, Holcomb NP, Jaquish A, Palashikar G, Soewignjo M, McDaniel M, Matsumoto I, Margolskee R,Von Moltke J, Cohen NA, Sun X, Vaughan AE. Injury-induced pulmonary tuft cells are heterogenous, arise independent of key Type 2 cytokines, and are dispensable for dysplastic repair. Elife. 2022 Sep 8;11. doi: 10.7554/eLife.78074. PubMed PMID: 36073526; PubMed Central PMCID: PMC9553214.

Zhao P, Sun X, Liao Z, Yu H, Li D, Shen Z, Glass CK, Witztum JL, Saltiel AR. The TBK1/IKKε inhibitor amlexanox improves dyslipidemia and prevents atherosclerosis. JCI Insight. 2022 Sep 8;7(17). doi: 10.1172/jci.insight.155552. PubMed PMID: 35917178; PubMed Central PMCID: PMC9536260. Xu M,

Zhou J, Cheng Y, Jin Z, Clark AE, He T, Yim W, Li Y, Chang YC, Wu Z, Fajtová P, O'Donoghue AJ, Carlin AF, Todd MD, Jokerst JV. A Self-Immolative Fluorescent Probe for Selective Detection of SARS-CoV-2 Main Protease. Anal Chem. 2022 Aug 30;94(34):11728-11733. doi: 10.1021/acs.analchem.2c02381. Epub 2022 Aug 16. PubMed PMID: 35973073; PubMed Central PMCID: PMC9396966.

Wang L, Lin L, Qi H, Chen J, Grossfeld P. Endothelial Loss of ETS1 Impairs Coronary Vascular Development and Leads to Ventricular Non-Compaction. Circ Res. 2022 Aug 19;131(5):371-387. doi: 10.1161/CIRCRESAHA.121.319955. Epub 2022 Jul 27. PubMed PMID: 35894043; PubMed Central PMCID: PMC9624262.

Cobo I, Tanaka TN, Chandra Mangalhara K, Lana A, Yeang C, Han C, Schlachetzki J, Challcombe J, Fixsen BR, Sakai M, Li RZ, Fields H, Mokry M, Tsai RG, Bejar R, Prange K, de Winther M, Shadel GS, Glass CK. DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages. Immunity. 2022 Aug 9;55(8):1386-1401.e10. doi: 10.1016/j.immuni.2022.06.022. Epub 2022 Aug 4. PubMed PMID: 35931086; PubMed Central PMCID: PMC9718507.

Gamliel A, Meluzzi D, Oh S, Jiang N, Destici E, Rosenfeld MG, Nair SJ. Long-distance association of topological boundaries through nuclear condensates. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2206216119. doi: 10.1073/pnas.2206216119. Epub 2022 Aug 1. PubMed PMID: 35914133; PubMed Central PMCID: PMC9371644.

Tonsfeldt KJ, Cui LJ, Lee J, Walbeek TJ, Brusman LE, Jin Y, Mieda M, Gorman MR, Mellon PL. Female fertility does not require Bmal1 in suprachiasmatic nucleus neurons expressing arginine vasopressin, vasoactive intestinal peptide, or neuromedin-S. Front Endocrinol (Lausanne). 2022;13:956169. doi: 10.3389/fendo.2022.956169. eCollection 2022. PubMed PMID: 35992114; PubMed Central PMCID: PMC9389073.

Gao H, Jin Z, Bandyopadhyay G, Wang G, Zhang D, Rocha KCE, Liu X, Zhao H, Kisseleva T, Brenner DA, Karin M, Ying W. Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis. Cell Metab. 2022 Aug 2;34(8):1201-1213.e5. doi: 10.1016/j.cmet.2022.07.006. PubMed PMID: 35921818; PubMed Central PMCID: PMC9365100.

Miller M, Pham AK, Gonen A, Navia-Pelaez JM, Xia K, Park S, Osterman AL, Bacon K, Beaton G, Kurten RC, Broide DH, Miller YI. Reduced AIBP expression in bronchial epithelial cells of asthmatic patients: Potential therapeutic target. Clin Exp Allergy. 2022 Aug;52(8):979-984. doi: 10.1111/cea.14150. Epub 2022 Apr 26. PubMed PMID: 35460293.

Luo Z, Ji Y, Zhang D, Gao H, Jin Z, Yang M, Ying W. Microbial DNA enrichment promotes liver steatosis and fibrosis in the course of non-alcoholic steatohepatitis. Acta Physiol (Oxf). 2022 Jul;235(3):e13827. doi: 10.1111/apha.13827. Epub 2022 May 10. PubMed PMID: 35500155; PubMed Central PMCID: PMC9335517.

Torres A, Pedersen B, Cobo I, Ai R, Coras R, Murillo-Saich J, Nygaard G, Sanchez-Lopez E, Murphy A, Wang W, Firestein GS, Guma M. Epigenetic Regulation of Nutrient Transporters in Rheumatoid Arthritis Fibroblast-like Synoviocytes. Arthritis Rheumatol. 2022 Jul;74(7):1159-1171. doi: 10.1002/art.42077. Epub 2022 Jun 2. PubMed PMID: 35128827; PubMed Central PMCID: PMC9246826.

Wang H, Alarcón CN, Liu B, Watson F, Searles S, Lee CK, Keys J, Pi W, Allen D, Lammerding J, Bui JD, Klemke RL. Genetically engineered and enucleated human mesenchymal stromal cells for the targeted delivery of therapeutics to diseased tissue. Nat Biomed Eng. 2022 Jul;6(7):882-897. doi: 10.1038/s41551-021-00815-9. Epub 2021 Dec 20. PubMed PMID: 34931077; PubMed Central PMCID: PMC9207157.

Avansini SH, Puppo F, Adams JW, Vieira AS, Coan AC, Rogerio F, Torres FR, Araújo PAOR, Martin M, Montenegro MA, Yasuda CL, Tedeschi H, Ghizoni E, França AFEC, Alvim MKM, Athié MC, Rocha CS, Almeida VS, Dias EV, Delay L, Molina E, Yaksh TL, Cendes F, Lopes Cendes I, Muotri AR. Junctional instability in neuroepithelium and network hyperexcitability in a focal cortical dysplasia human model. Brain. 2022 Jun 30;145(6):1962-1977. doi: 10.1093/brain/awab479. PubMed PMID: 34957478; PubMed Central PMCID: PMC9336577.

Sedat J, McDonald A, Cang H, Lucas J, Arigovindan M, Kam Z, Murre C, Elbaum M. A proposed unified interphase nucleus chromosome structure: Preliminary preponderance of evidence. Proc Natl Acad Sci U S A. 2022 Jun 28;119(26):e2119101119. doi: 10.1073/pnas.2119101119. Epub 2022 Jun 24. PubMed PMID: 35749363; PubMed Central PMCID: PMC9245672.

Kanbar JN, Ma S, Kim ES, Kurd NS, Tsai MS, Tysl T, Widjaja CE, Limary AE, Yee B, He Z, Hao Y, Fu XD, Yeo GW, Huang WJ, Chang JT. The long noncoding RNA Malat1 regulates CD8+ T cell differentiation by mediating epigenetic repression. J Exp Med. 2022 Jun 6;219(6). doi: 10.1084/jem.20211756. Epub 2022 May 20. PubMed PMID: 35593887; PubMed Central PMCID: PMC9127983.

Saikia JM, Chavez-Martinez CL, Kim ND, Allibhoy S, Kim HJ, Simonyan L, Smadi S, Tsai KM, Romaus-Sanjurjo D, Jin Y, Zheng B. A Critical Role for DLK and LZK in Axonal Repair in the Mammalian Spinal Cord. J Neurosci. 2022 May 4;42(18):3716-3732. doi: 10.1523/JNEUROSCI.2495-21.2022. Epub 2022 Mar 31. PubMed PMID: 35361703; PubMed Central PMCID: PMC9087816.

Breuss MW, Yang X, Schlachetzki JCM, Antaki D, Lana AJ, Xu X, Chung C, Chai G, Stanley V, Song Q, Newmeyer TF, Nguyen A, O'Brien S, Hoeksema MA, Cao B, Nott A, McEvoy-Venneri J, Pasillas MP, Barton ST, Copeland BR, Nahas S, Van Der Kraan L, Ding Y, Glass CK, Gleeson JG. Somatic mosaicism reveals clonal distributions of neocortical development. Nature. 2022 Apr;604(7907):689-696. doi: 10.1038/s41586-022-04602-7. Epub 2022 Apr 20. PubMed PMID: 35444276; PubMed Central PMCID: PMC9436791.

Wu Z, Zhou J, Nkanga CI, Jin Z, He T, Borum RM, Yim W, Zhou J, Cheng Y, Xu M, Steinmetz NF, Jokerst JV. One-Step Supramolecular Multifunctional Coating on Plant Virus Nanoparticles for Bioimaging and Therapeutic Applications. ACS Appl Mater Interfaces. 2022 Mar 23;14(11):13692-13702. doi: 10.1021/acsami.1c22690. Epub 2022 Mar 8. PubMed PMID: 35258299; PubMed Central PMCID: PMC9159738.

Moinpour M, Fracassi A, Brea RJ, Salvador-Castell M, Pandey S, Edwards MM, Seifert S, Joseph S, Sinha SK, Devaraj NK. Controlling Protein Enrichment in Lipid Sponge Phase Droplets using SNAP-Tag Bioconjugation. Chembiochem. 2022 Mar 4;23(5):e202100624. doi: 10.1002/cbic.202100624. Epub 2022 Jan 19. PubMed PMID: 34936727.

Spahn PN, Zhang X, Hu Q, Lu H, Hamaker NK, Hefzi H, Li S, Kuo CC, Huang Y, Lee JC, Davis AJ, Ly P, Lee KH, Lewis NE. Restoration of DNA repair mitigates genome instability and increases productivity of Chinese hamster ovary cells. Biotechnol Bioeng. 2022 Mar;119(3):963-982. doi: 10.1002/bit.28016. Epub 2022 Jan 5. PubMed PMID: 34953085; PubMed Central PMCID: PMC8821244.

Wu T, Liang Z, Zhang Z, Liu C, Zhang L, Gu Y, Peterson KL, Evans SM, Fu XD, Chen J. PRDM16 Is a Compact Myocardium-Enriched Transcription Factor Required to Maintain Compact Myocardial Cardiomyocyte Identity in Left Ventricle. Circulation. 2022 Feb 22;145(8):586-602. doi: 10.1161/CIRCULATIONAHA.121.056666. Epub 2021 Dec 17. PubMed PMID: 34915728; PubMed Central PMCID: PMC8860879.

Gao H, Jin Z, Tang K, Ji Y, Suarez J, Suarez JA, Cunha E Rocha K, Zhang D, Dillmann WH, Mahata SK, Ying W. Microbial DNA Enrichment Promotes Adrenomedullary Inflammation, Catecholamine Secretion, and Hypertension in Obese Mice. J Am Heart Assoc. 2022 Feb 15;11(4):e024561. doi: 10.1161/JAHA.121.024561. Epub 2022 Feb 3. PubMed PMID: 35112881; PubMed Central PMCID: PMC9245808.

Lin HH, Kuang MC, Hossain I, Xuan Y, Beebe L, Shepherd AK, Rolandi M, Wang JW. A nutrient-specific gut hormone arbitrates between courtship and feeding. Nature. 2022 Feb;602(7898):632-638. doi: 10.1038/s41586-022-04408-7. Epub 2022 Feb 9. PubMed PMID: 35140404; PubMed Central PMCID: PMC9271372.

Liang Y, Kaneko K, Xin B, Lee J, Sun X, Zhang K, Feng GS. Temporal analyses of postnatal liver development and maturation by single-cell transcriptomics. Dev Cell. 2022 Feb 7;57(3):398-414.e5. doi: 10.1016/j.devcel.2022.01.004. PubMed PMID: 35134346; PubMed Central PMCID: PMC8842999.

Indralingam CS, Gutierrez-Gonzalez AK, Johns SC, Tsui T, Cannon DT, Fuster MM, Bigby TD, Jennings PA, Breen EC. IL-33/ST2 receptor-dependent signaling in the development of pulmonary hypertension in Sugen/hypoxia mice. Physiol Rep. 2022 Feb;10(3):e15185. doi: 10.14814/phy2.15185. PubMed PMID: 35150208; PubMed Central PMCID: PMC8839421.

Wu ST, Chen JY, Martin V, Ng R, Zhang Y, Grover D, Greenspan RJ, Aljadeff J, Su CY. Valence opponency in peripheral olfactory processing. Proc Natl Acad Sci U S A. 2022 Feb 1;119(5). doi: 10.1073/pnas.2120134119. PubMed PMID: 35091473; PubMed Central PMCID: PMC8812543.

Mills RH, Dulai PS, Vázquez-Baeza Y, Sauceda C, Daniel N, Gerner RR, Batachari LE, Malfavon M, Zhu Q, Weldon K, Humphrey G, Carrillo-Terrazas M, Goldasich LD, Bryant M, Raffatellu M, Quinn RA, Gewirtz AT, Chassaing B, Chu H, Sandborn WJ, Dorrestein PC, Knight R, Gonzalez DJ. Multi-omics analyses of the ulcerative colitis gut microbiome link Bacteroides vulgatus proteases with disease severity. Nat Microbiol. 2022 Feb;7(2):262-276. doi: 10.1038/s41564-021-01050-3. Epub 2022 Jan 27. PubMed PMID: 35087228; PubMed Central PMCID: PMC8852248.

Gao H, Luo Z, Ji Y, Tang K, Jin Z, Ly C, Sears DD, Mahata S, Ying W. Accumulation of microbial DNAs promotes to islet inflammation and β cell abnormalities in obesity in mice. Nat Commun. 2022 Jan 28;13(1):565. doi:
10.1038/s41467-022-28239-2. PubMed PMID: 35091566; PubMed Central PMCID: PMC8799656.

Kamioka M, Goto Y, Nakamura K, Yokoi Y, Sugimoto R, Ohira S, Kurashima Y, Umemoto S, Sato S, Kunisawa J, Takahashi Y, Domino SE, Renauld JC, Nakae S, Iwakura Y, Ernst PB, Ayabe T, Kiyono H. Intestinal commensal microbiota and cytokines regulate Fut2+ Paneth cells for gut defense. Proc Natl Acad Sci U S A. 2022 Jan 18;119(3). doi: 10.1073/pnas.2115230119. PubMed PMID: 35027453; PubMed Central PMCID: PMC8784097.

2021

Moon, J. S. et al. ANT2 drives proinflammatory macrophage activation in obesity. JCI Insight 6, doi:10.1172/jci.insight.147033 (2021).

Diaz-Garcia, S. et al. Nuclear depletion of RNA-binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosis. Acta Neuropathol 142, 985-1001, doi:10.1007/s00401-021-02374-4 (2021).

Ban, Y. et al. Prickle promotes the formation and maintenance of glutamatergic synapses by stabilizing the intercellular planar cell polarity complex. Sci Adv 7, eabh2974, doi:10.1126/sciadv.abh2974 (2021).

Honigfort, D. J., Altman, M. O., Gagneux, P. & Godula, K. Glycocalyx crowding with mucin mimetics strengthens binding of soluble and virus-associated lectins to host cell glycan receptors. Proc Natl Acad Sci U S A 118, doi:10.1073/pnas.2107896118 (2021).

Kroeger, H. et al. ATF6 is essential for human cone photoreceptor development. Proc Natl Acad Sci U S A 118, doi:10.1073/pnas.2103196118 (2021).

Monaghan, C. E., Adamson, S. I., Kapur, M., Chuang, J. H. & Ackerman, S. L. The Clp1 R140H mutation alters tRNA metabolism and mRNA 3' processing in mouse models of pontocerebellar hypoplasia. Proc Natl Acad Sci U S A 118, doi:10.1073/pnas.2110730118 (2021).

Golden, G. J. et al. Endothelial Heparan Sulfate Mediates Hepatic Neutrophil Trafficking and Injury during Staphylococcus aureus Sepsis. mBio 12, e0118121, doi:10.1128/mBio.01181-21 (2021).

Ho, E. V. et al. Reproductive Deficits Induced by Prenatal Antimullerian Hormone Exposure Require Androgen Receptor in Kisspeptin Cells. Endocrinology 162, doi:10.1210/endocr/bqab197 (2021).

Urresti, J. et al. Cortical organoids model early brain development disrupted by 16p11.2 copy number variants in autism. Mol Psychiatry, doi:10.1038/s41380-021-01243-6 (2021).

Feng, B. et al. Planar cell polarity signaling components are a direct target of beta-amyloid-associated degeneration of glutamatergic synapses. Sci Adv 7, doi:10.1126/sciadv.abh2307 (2021).

Bogomolovas, J. et al. Titin kinase ubiquitination aligns autophagy receptors with mechanical signals in the sarcomere. EMBO Rep 22, e48018, doi:10.15252/embr.201948018 (2021).

Wang, L. et al. A human three-dimensional neural-perivascular 'assembloid' promotes astrocytic development and enables modeling of SARS-CoV-2 neuropathology. Nat Med 27, 1600-1606, doi:10.1038/s41591-021-01443-1 (2021).

Sant, V., Som, M., Karkisaval, A. G., Carnahan, P. & Lal, R. Scavenging amyloid oligomers from neurons with silica nanobowls: Implications for amyloid diseases. Biophys J 120, 3329-3340, doi:10.1016/j.bpj.2021.07.002 (2021).

Sapp, V. et al. Genome-wide CRISPR/Cas9 screening in human iPS derived cardiomyocytes uncovers novel mediators of doxorubicin cardiotoxicity. Sci Rep 11, 13866, doi:10.1038/s41598-021-92988-1 (2021).

Hoffmann, H. M. et al. The transcription factors SIX3 and VAX1 are required for suprachiasmatic nucleus circadian output and fertility in female mice. J Neurosci Res 99, 2625-2645, doi:10.1002/jnr.24864 (2021).

Cao, K. J. et al. ARCAM-1 Facilitates Fluorescence Detection of Amyloid-Containing Deposits in the Retina. Transl Vis Sci Technol 10, 5, doi:10.1167/tvst.10.7.5 (2021).

Maimon, R. et al. Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB. Nat Neurosci 24, 1089-1099, doi:10.1038/s41593-021-00864-y (2021).

Ganguly, S. et al. Nonalcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet. Cell Mol Gastroenterol Hepatol 12, 891-920, doi:10.1016/j.jcmgh.2021.05.010 (2021).

Lopez-Ramirez, M. A. et al. Astrocytes propel neurovascular dysfunction during cerebral cavernous malformation lesion formation. J Clin Invest 131, doi:10.1172/JCI139570 (2021).

Li, W. et al. Abortive intussusceptive angiogenesis causes multi-cavernous vascular malformations. Elife 10, doi:10.7554/eLife.62155 (2021).

Mesarwi, O. A. et al. Hepatocyte HIF-1 and Intermittent Hypoxia Independently Impact Liver Fibrosis in Murine Nonalcoholic Fatty Liver Disease. Am J Respir Cell Mol Biol 65, 390-402, doi:10.1165/rcmb.2020-0492OC (2021).

Schwaerzer, G. K. et al. Constitutive protein kinase G activation exacerbates stress-induced cardiomyopathy. Br J Pharmacol, doi:10.1111/bph.15530 (2021).

Navia-Pelaez, J. M. et al. Normalization of cholesterol metabolism in spinal microglia alleviates neuropathic pain. J Exp Med 218, doi:10.1084/jem.20202059 (2021).

Kim, W. E. et al. Synthase-Selective Exploration of a Tunicate Microbiome by Activity-Guided Single-Cell Genomics. ACS Chem Biol 16, 813-819, doi:10.1021/acschembio.1c00157 (2021).

Liao, Z., Gingras, A. R., Lagarrigue, F., Ginsberg, M. H. & Shattil, S. J. Optogenetics-based localization of talin to the plasma membrane promotes activation of beta3 integrins. J Biol Chem 296, 100675, doi:10.1016/j.jbc.2021.100675 (2021).

Liang, Y. et al. Desmosomal COP9 regulates proteome degradation in arrhythmogenic right ventricular dysplasia/cardiomyopathy. J Clin Invest 131, doi:10.1172/JCI137689 (2021).

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Amar, M. et al. Autism-linked Cullin3 germline haploinsufficiency impacts cytoskeletal dynamics and cortical neurogenesis through RhoA signaling. Mol Psychiatry 26, 3586-3613, doi:10.1038/s41380-021-01052-x (2021).

Zhou, T. et al. Molecular Characterisation of Titin N2A and Its Binding of CARP Reveals a Titin/Actin Cross-linking Mechanism. J Mol Biol 433, 166901, doi:10.1016/j.jmb.2021.166901 (2021).

Gleeson, J. et al. A Human 3D neural assembloid model for SARS-CoV-2 infection. Res Sq, doi:10.21203/rs.3.rs-214352/v1 (2021).

Aladesuyi Arogundade, O. et al. Nucleolar stress in C9orf72 and sporadic ALS spinal motor neurons precedes TDP-43 mislocalization. Acta Neuropathol Commun 9, 26, doi:10.1186/s40478-021-01125-6 (2021).

Dorrier, C. E. et al. CNS fibroblasts form a fibrotic scar in response to immune cell infiltration. Nat Neurosci 24, 234-244, doi:10.1038/s41593-020-00770-9 (2021).

Tang, M. et al. Rapid 3D Bioprinting of Glioblastoma Model Mimicking Native Biophysical Heterogeneity. Small 17, e2006050, doi:10.1002/smll.202006050 (2021).

Lu, S. et al. The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein. Nat Commun 12, 502, doi:10.1038/s41467-020-20768-y (2021).

Li, Y. et al. Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength. Elife 10, doi:10.7554/eLife.63509 (2021).

Bali, P., Lozano-Pope, I., Pachow, C. & Obonyo, M. Early detection of tumor cells in bone marrow and peripheral blood in a fastprogressing gastric cancer model. Int J Oncol 58, 388-396, doi:10.3892/ijo.2021.5171 (2021).

Naticchia, M. R., Laubach, L. K., Honigfort, D. J., Purcell, S. C. & Godula, K. Spatially controlled glycocalyx engineering for growth factor patterning in embryoid bodies. Biomater Sci 9, 1652-1659, doi:10.1039/d0bm01434f (2021).

Choi, S. H. et al. Intracellular AIBP (Apolipoprotein A-I Binding Protein) Regulates Oxidized LDL (Low-Density Lipoprotein)-Induced Mitophagy in Macrophages. Arterioscler Thromb Vasc Biol 41, e82-e96, doi:10.1161/ATVBAHA.120.315485 (2021).

Yu, H. et al. HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells. Science 371, doi:10.1126/science.abb4309 (2021).

Zhu, Y., Denholtz, M., Lu, H. & Murre, C. Calcium signaling instructs NIPBL recruitment at active enhancers and promoters via distinct mechanisms to reconstruct genome compartmentalization. Genes Dev 35, 65-81, doi:10.1101/gad.343475.120 (2021).

Cividini, F. et al. Ncor2/PPARalpha-Dependent Upregulation of MCUb in the Type 2 Diabetic Heart Impacts Cardiac Metabolic Flexibility and Function. Diabetes 70, 665-679, doi:10.2337/db20-0779 (2021).

Chai, G. et al. Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly. Neuron 109, 241-256 e249, doi:10.1016/j.neuron.2020.10.035 (2021).

Ghosh, S. G. et al. Biallelic variants in HPDL, encoding 4-hydroxyphenylpyruvate dioxygenase-like protein, lead to an infantile neurodegenerative condition. Genet Med 23, 524-533, doi:10.1038/s41436-020-01010-y (2021).

Samoudi, M. et al. In situ detection of protein interactions for recombinant therapeutic enzymes. Biotechnol Bioeng 118, 890-904, doi:10.1002/bit.27621 (2021).

Luo, Z. et al. CRIg(+) Macrophages Prevent Gut Microbial DNA-Containing Extracellular Vesicle-Induced Tissue Inflammation and Insulin Resistance. Gastroenterology 160, 863-874, doi:10.1053/j.gastro.2020.10.042 (2021).

Dore, K. & Malinow, R. Elevated PSD-95 Blocks Ion-flux Independent LTD: A Potential New Role for PSD-95 in Synaptic Plasticity. Neuroscience 456, 43-49, doi:10.1016/j.neuroscience.2020.02.020 (2021).

2020

Blondelle, J., Biju, A. & Lange, S. The Role of Cullin-RING Ligases in Striated Muscle Development, Function, and Disease. Int J Mol Sci 21, doi:10.3390/ijms21217936 (2020).

Bogomolovas, J. et al. Atypical ALPK2 kinase is not essential for cardiac development and function. Am J Physiol Heart Circ Physiol 318, H1509-H1515, doi:10.1152/ajpheart.00249.2020 (2020).

Boland, B. S. et al. Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses. Sci Immunol 5, doi:10.1126/sciimmunol.abb4432 (2020).

Breuss, M. W. et al. Autism risk in offspring can be assessed through quantification of male sperm mosaicism. Nat Med 26, 143-150, doi:10.1038/s41591-019-0711-0 (2020).

Church, D. C. & Pokorski, J. K. Cell Engineering with Functional Poly(oxanorbornene) Block Copolymers. Angew Chem Int Ed Engl 59, 11379-11383, doi:10.1002/anie.202005148 (2020).

Clark, A. E. et al. Zika virus is transmitted in neural progenitor cells via cell-to-cell spread and infection is inhibited by the autophagy inducer trehalose. J Virol, doi:10.1128/JVI.02024-20 (2020).

den Hartog, G. et al. Apurinic/Apyrimidinic Endonuclease 1 Restricts the Internalization of Bacteria Into Human Intestinal Epithelial Cells Through the Inhibition of Rac1. Front Immunol 11, 553994, doi:10.3389/fimmu.2020.553994 (2020).

Ghosh, S. G. et al. Recurrent homozygous damaging mutation in TMX2, encoding a protein disulfide isomerase, in four families with microlissencephaly. J Med Genet 57, 274-282, doi:10.1136/jmedgenet-2019-106409 (2020).

Holland, N. D. & Somorjai, I. M. L. The sensory peripheral nervous system in the tail of a cephalochordate studied by serial blockface scanning electron microscopy. J Comp Neurol 528, 2569-2582, doi:10.1002/cne.24913 (2020).

Jimenez Calvente, C., Del Pilar, H., Tameda, M., Johnson, C. D. & Feldstein, A. E. MicroRNA 223 3p Negatively Regulates the NLRP3 Inflammasome in Acute and Chronic Liver Injury. Mol Ther 28, 653-663, doi:10.1016/j.ymthe.2019.09.013 (2020).

Labarta-Bajo, L. et al. Type I IFNs and CD8 T cells increase intestinal barrier permeability after chronic viral infection. J Exp Med 217, doi:10.1084/jem.20192276 (2020).

Lange, S., Pinotsis, N., Agarkova, I. & Ehler, E. The M-band: The underestimated part of the sarcomere. Biochim Biophys Acta Mol Cell Res 1867, 118440, doi:10.1016/j.bbamcr.2019.02.003 (2020).

Lee, S. & Gleeson, J. G. Closing in on Mechanisms of Open Neural Tube Defects. Trends Neurosci 43, 519-532, doi:10.1016/j.tins.2020.04.009 (2020).

Lund, S. J. et al. Developmental Immaturity of Siglec Receptor Expression on Neonatal Alveolar Macrophages Predisposes to Severe Group B Streptococcal Infection. iScience 23, 101207, doi:10.1016/j.isci.2020.101207 (2020).

Marsala, M. et al. Spinal parenchymal occupation by neural stem cells after subpial delivery in adult immunodeficient rats. Stem Cells Transl Med 9, 177-188, doi:10.1002/sctm.19-0156 (2020).

Onishi, K. et al. LRRK2 mediates axon development by regulating Frizzled3 phosphorylation and growth cone-growth cone communication. Proc Natl Acad Sci U S A 117, 18037-18048, doi:10.1073/pnas.1921878117 (2020).

Ozdinler, P. H. et al. Better understanding the neurobiology of primary lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener 21, 35-46, doi:10.1080/21678421.2020.1837175 (2020).

Park, G. et al. Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid beta-Protein-Induced Synapse Loss in Alzheimer's Disease. Cell Rep 31, 107839, doi:10.1016/j.celrep.2020.107839 (2020).

Paschoal, V. A. et al. Positive Reinforcing Mechanisms between GPR120 and PPARgamma Modulate Insulin Sensitivity. Cell Metab 31, 1173-1188 e1175, doi:10.1016/j.cmet.2020.04.020 (2020).

Reilly, S. M. et al. Catecholamines suppress fatty acid re-esterification and increase oxidation in white adipocytes via STAT3. Nat Metab 2, 620-634, doi:10.1038/s42255-020-0217-6 (2020).

Schall, N. et al. Protein kinase G1 regulates bone regeneration and rescues diabetic fracture healing. JCI Insight 5, doi:10.1172/jci.insight.135355 (2020).

Sidhwani, P. et al. Cardiac function modulates endocardial cell dynamics to shape the cardiac outflow tract. Development 147, doi:10.1242/dev.185900 (2020).

Sperk, G. et al. Immunohistochemical distribution of 10 GABAA receptor subunits in the forebrain of the rhesus monkey Macaca mulatta. J Comp Neurol 528, 2551-2568, doi:10.1002/cne.24910 (2020).

Sulaeman, A. et al. Synergistic effect of vascular endothelial growth factor gene inactivation in endothelial cells and skeletal myofibres on muscle enzyme activity, capillary supply and endurance exercise in mice. Exp Physiol 105, 2168-2177, doi:10.1113/EP088924 (2020).

Tang, M. et al. Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions. Cell Res 30, 833-853, doi:10.1038/s41422-020-0338-1 (2020).

Teodorof-Diedrich, C. & Spector, S. A. Human Immunodeficiency Virus Type 1 and Methamphetamine-Mediated Mitochondrial Damage and Neuronal Degeneration in Human Neurons. J Virol 94, doi:10.1128/JVI.00924-20 (2020).

Terrey, M. et al. GTPBP1 resolves paused ribosomes to maintain neuronal homeostasis. Elife 9, doi:10.7554/eLife.62731 (2020).

Tsuboi, T. et al. Mitochondrial volume fraction and translation duration impact mitochondrial mRNA localization and protein synthesis. Elife 9, doi:10.7554/eLife.57814 (2020).

Valentine, K. M., Croft, M. & Shresta, S. Protection against dengue virus requires a sustained balance of antibody and T cell responses. Curr Opin Virol 43, 22-27, doi:10.1016/j.coviro.2020.07.018 (2020).

Wahwah, N. et al. Metabolic interaction between amino acid deprivation and cisplatin synergistically reduces phosphoribosyl-pyrophosphate and augments cisplatin cytotoxicity. Sci Rep 10, 19907, doi:10.1038/s41598-020-76958-7 (2020).

Wen, J. et al. CD4(+) T Cells Cross-Reactive with Dengue and Zika Viruses Protect against Zika Virus Infection. Cell Rep 31, 107566, doi:10.1016/j.celrep.2020.107566 (2020).

Young, R. E. et al. Smooth Muscle Differentiation Is Essential for Airway Size, Tracheal Cartilage Segmentation, but Dispensable for Epithelial Branching. Dev Cell 53, 73-85 e75, doi:10.1016/j.devcel.2020.02.001 (2020).

Zhang, J. et al. Cardiomyocyte Expression of ZO-1 Is Essential for Normal Atrioventricular Conduction but Does Not Alter Ventricular Function. Circ Res 127, 284-297, doi:10.1161/CIRCRESAHA.119.315539 (2020).

Zhao, P. et al. An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis. Science 367, 652-660, doi:10.1126/science.aay0542 (2020).

2019

Wu S, Turner KM, Nguyen N, Raviram R, Erb M, Santini J, Luebeck J, Rajkumar U, Diao Y, Li B, Zhang W, Jameson N, Corces MR, Granja JM, Chen X, Coruh C, Abnousi A, Houston J, Ye Z, Hu R, Yu M, Kim H, Law JA, Verhaak RGW, Hu M, Furnari FB, Chang HY, Ren B, Bafna V, Mischel PS. Circular ecDNA promotes accessible chromatin and high oncogene expression. Nature. 2019 Nov 20. PMID:31748743

Ackermann BE, Debelouchina GT. Heterochromatin Protein HP1alpha Gelation Dynamics Revealed by Solid-State NMR Spectroscopy. Angew Chem Int Ed Engl 2019;58(19):6300-5. PMCID: PMC6482055.

Aladesuyi Arogundade O, Stauffer JE, Saberi S, Diaz-Garcia S, Malik S, Basilim H, Rodriguez MJ, Ohkubo T, Ravits J. Antisense RNA foci are associated with nucleoli and TDP-43 mislocalization in C9orf72-ALS/FTD: a quantitative study. Acta Neuropathol 2019;137(3):527-30. PMCID: PMC6397670.

Bi J, Ichu TA, Zanca C, Yang H, Zhang W, Gu Y, Chowdhry S, Reed A, Ikegami S, Turner KM, Zhang W, Villa GR, Wu S, Quehenberger O, Yong WH, Kornblum HI, Rich JN, Cloughesy TF, Cavenee WK, Furnari FB, Cravatt BF, Mischel PS. Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling. Cell Metab 2019;30(3):525-38 e8. PMCID: PMC6742496.

Blondelle J, Marrocco V, Clark M, Desmond P, Myers S, Nguyen J, Wright M, Bremner S, Pierantozzi E, Ward S, Esteve E, Sorrentino V, Ghassemian M, Lange S. Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism. Commun Biol 2019;2:178. PMCID: PMC6509138.

Blondelle J, Tallapaka K, Seto JT, Ghassemian M, Clark M, Laitila JM, Bournazos A, Singer JD, Lange S. Cullin-3 dependent deregulation of ACTN1 represents a new pathogenic mechanism in nemaline myopathy. JCI Insight 2019;5. PMCID: PMC6542616.

Courchesne E, Pramparo T, Gazestani VH, Lombardo MV, Pierce K, Lewis NE. The ASD Living Biology: from cell proliferation to clinical phenotype. Mol Psychiatry 2019;24(1):88-107. PMCID: PMC6309606.

Gasset-Rosa F, Lu S, Yu H, Chen C, Melamed Z, Guo L, Shorter J, Da Cruz S, Cleveland DW. Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death. Neuron 2019;102(2):339-57 e7. PMCID: PMC6548321.

Gonen A, Choi SH, Miu P, Agatisa-Boyle C, Acks D, Taylor AM, McNamara CA, Tsimikas S, Witztum JL, Miller YI. A monoclonal antibody to assess oxidized cholesteryl esters associated with apoAI and apoB-100 lipoproteins in human plasma. J Lipid Res 2019;60(2):436-45. PMCID: PMC6358287.

Guichard A, Haque T, Bobik M, Xu XS, Klanseck C, Kushwah RBS, Berni M, Kaduskar B, Gantz VM, Bier E. Efficient allelic-drive in Drosophila. Nat Commun 2019;10(1):1640. PMCID: PMC6456580.

Khanna N, Zhang Y, Lucas JS, Dudko OK, Murre C. Chromosome dynamics near the sol-gel phase transition dictate the timing of remote genomic interactions. Nat Commun 2019;10(1):2771. PMCID: PMC6591236.

Lange S, Banerjee I, Carrion K, Serrano R, Habich L, Kameny R, Lengenfelder L, Dalton N, Meili R, Borgeson E, Peterson K, Ricci M, Lincoln J, Ghassemian M, Fineman JR, Del Alamo JC, Nigam V. miR-486 is modulated by stretch and increases ventricular growth. JCI Insight 2019.

Lange S, Pinotsis N, Agarkova I, Ehler E. The M-band: The underestimated part of the sarcomere. Biochim Biophys Acta Mol Cell Res 2019.

Lopez-Ramirez MA, Pham A, Girard R, Wyseure T, Hale P, Yamashita A, Koskimaki J, Polster S, Saadat L, Romero IA, Esmon CT, Lagarrigue F, Awad IA, Mosnier LO, Ginsberg MH. Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice. Blood 2019;133(3):193-204. PMCID: PMC6337879.

Ly P, Brunner SF, Shoshani O, Kim DH, Lan W, Pyntikova T, Flanagan AM, Behjati S, Page DC, Campbell PJ, Cleveland DW. Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements. Nat Genet 2019;51(4):705-15. PMCID: PMC6441390.

Ma X, Dewan S, Liu J, Tang M, Miller KL, Yu C, Lawrence N, McCulloch AD, Chen S. 3D printed micro-scale force gauge arrays to improve human cardiac tissue maturation and enable high throughput drug testing. Acta Biomater 2019;95:319-27. PMCID: PMC6584548.

Nair SJ, Yang L, Meluzzi D, Oh S, Yang F, Friedman MJ, Wang S, Suter T, Alshareedah I, Gamliel A, Ma Q, Zhang J, Hu Y, Tan Y, Ohgi KA, Jayani RS, Banerjee PR, Aggarwal AK, Rosenfeld MG. Phase separation of ligand-activated enhancers licenses cooperative chromosomal enhancer assembly. Nat Struct Mol Biol 2019;26(3):193-203. PMCID: PMC6709854.

Neri T, Hiriart E, van Vliet PP, Faure E, Norris RA, Farhat B, Jagla B, Lefrancois J, Sugi Y, Moore-Morris T, Zaffran S, Faustino RS, Zambon AC, Desvignes JP, Salgado D, Levine RA, de la Pompa JL, Terzic A, Evans SM, Markwald R, Puceat M. Human pre-valvular endocardial cells derived from pluripotent stem cells recapitulate cardiac pathophysiological valvulogenesis. Nat Commun 2019;10(1):1929. PMCID: PMC6486645.

Povero D, Pinatel EM, Leszczynska A, Goyal NP, Nishio T, Kim J, Kneiber D, de Araujo Horcel L, Eguchi A, Ordonez PM, Kisseleva T, Feldstein AE. Human induced pluripotent stem cell-derived extracellular vesicles reduce hepatic stellate cell activation and liver fibrosis. JCI Insight 2019;5. PMCID: PMC6675559.

Schwaerzer GK, Kalyanaraman H, Casteel DE, Dalton ND, Gu Y, Lee S, Zhuang S, Wahwah N, Schilling JM, Patel HH, Zhang Q, Makino A, Milewicz DM, Peterson KL, Boss GR, Pilz RB. Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog. Nat Commun 2019;10(1):3533. PMCID: PMC6684604.

Tecle E, Reynoso HS, Wang R, Gagneux P. The female reproductive tract contains multiple innate sialic acid-binding immunoglobulin-like lectins (Siglecs) that facilitate sperm survival. J Biol Chem 2019;294(31):11910-9. PMCID: PMC6682739.

Yu C, Ma X, Zhu W, Wang P, Miller KL, Stupin J, Koroleva-Maharajh A, Hairabedian A, Chen S. Scanningless and continuous 3D bioprinting of human tissues with decellularized extracellular matrix. Biomaterials 2019;194:1-13. PMCID: PMC6339581.

Zhang Y, Chopp M, Rex CS, Simmon VF, Sarraf ST, Zhang ZG, Mahmood A, Xiong Y. A Small Molecule Spinogenic Compound Enhances Functional Outcome and Dendritic Spine Plasticity in a Rat Model of Traumatic Brain Injury. J Neurotrauma 2019;36(4):589-600. PMCID: PMC6354611.

Zheng B, Lorenzana AO, Ma L. Understanding the axonal response to injury by in vivo imaging in the mouse spinal cord: A tale of two branches. Exp Neurol 2019;318:277-85. PMCID: PMC6588497.

2018

Baumgartel K, Green A, Hornberger D, Lapira J, Rex C, Wheeler DG, Peters M. PDE4D regulates Spine Plasticity and Memory in the Retrosplenial Cortex. Sci Rep 2018;8(1):3895. PMCID: PMC5832851.

Boogerd CJ, Zhu X, Aneas I, Sakabe N, Zhang L, Sobreira DR, Montefiori L, Bogomolovas J, Joslin AC, Zhou B, Chen J, Nobrega MA, Evans SM. Tbx20 Is Required in Mid-Gestation Cardiomyocytes and Plays a Central Role in Atrial Development. Circ Res 2018;123(4):428-42. PMCID: PMC6092109.

Breuss MW, Nguyen A, Song Q, Nguyen T, Stanley V, James KN, Musaev D, Chai G, Wirth SA, Anzenberg P, George RD, Johansen A, Ali S, Zia-Ur-Rehman M, Sultan T, Zaki MS, Gleeson JG. Mutations in LNPK, Encoding the Endoplasmic Reticulum Junction Stabilizer Lunapark, Cause a Recessive Neurodevelopmental Syndrome. Am J Hum Genet 2018;103(2):296-304. PMCID: PMC6080764.

Bustamante MF, Oliveira PG, Garcia-Carbonell R, Croft AP, Smith JM, Serrano RL, Sanchez-Lopez E, Liu X, Kisseleva T, Hay N, Buckley CD, Firestein GS, Murphy AN, Miyamoto S, Guma M. Hexokinase 2 as a novel selective metabolic target for rheumatoid arthritis. Ann Rheum Dis 2018;77(11):1636-43. PMCID: PMC6328432.

Chen M, Geoffroy CG, Meves JM, Narang A, Li Y, Nguyen MT, Khai VS, Kong X, Steinke CL, Carolino KI, Elziere L, Goldberg MP, Jin Y, Zheng B. Leucine Zipper-Bearing Kinase Is a Critical Regulator of Astrocyte Reactivity in the Adult Mammalian CNS. Cell Rep 2018;22(13):3587-97. PMCID: PMC5905706.

Choi SH, Wallace AM, Schneider DA, Burg E, Kim J, Alekseeva E, Ubags ND, Cool CD, Fang L, Suratt BT, Miller YI. AIBP augments cholesterol efflux from alveolar macrophages to surfactant and reduces acute lung inflammation. JCI Insight 2018;3(16). PMCID: PMC6141166.

Clark AE, Sabalza M, Gordts P, Spector DH. Human Cytomegalovirus Replication Is Inhibited by the Autophagy-Inducing Compounds Trehalose and SMER28 through Distinctively Different Mechanisms. J Virol 2018;92(6). PMCID: PMC5827393.

De La Zerda DJ, Stokes JA, Do J, Go A, Fu Z, Powell FL. Ibuprofen does not reverse ventilatory acclimatization to chronic hypoxia. Respir Physiol Neurobiol 2018;256:29-35.

Eguchi A, Koyama Y, Wree A, Johnson CD, Nakamura R, Povero D, Kneiber D, Tameda M, Contreras P, Spada A, Feldstein AE. Emricasan, a pan-caspase inhibitor, improves survival and portal hypertension in a murine model of common bile-duct ligation. J Mol Med (Berl) 2018;96(6):575-83. PMCID: PMC6347405.

Friedman B, Whitney MA, Savariar EN, Caneda C, Steinbach P, Xiong Q, Hingorani DV, Crisp J, Adams SR, Kenner M, Lippert CN, Nguyen QT, Guma M, Tsien RY, Corr M. Detection of Subclinical Arthritis in Mice by a Thrombin Receptor-Derived Imaging Agent. Arthritis Rheumatol 2018;70(1):69-79. PMCID: PMC5745304.

Guemez-Gamboa A, Caglayan AO, Stanley V, Gregor A, Zaki MS, Saleem SN, Musaev D, McEvoy-Venneri J, Belandres D, Akizu N, Silhavy JL, Schroth J, Rosti RO, Copeland B, Lewis SM, Fang R, Issa MY, Per H, Gumus H, Bayram AK, Kumandas S, Akgumus GT, Erson-Omay EZ, Yasuno K, Bilguvar K, Heimer G, Pillar N, Shomron N, Weissglas-Volkov D, Porat Y, Einhorn Y, Gabriel S, Ben-Zeev B, Gunel M, Gleeson JG. Loss of Protocadherin-12 Leads to Diencephalic-Mesencephalic Junction Dysplasia Syndrome. Ann Neurol 2018;84(5):638-47. PMCID: PMC6510237.

Hingorani DV, Lippert CN, Crisp JL, Savariar EN, Hasselmann JPC, Kuo C, Nguyen QT, Tsien RY, Whitney MA, Ellies LG. Impact of MMP-2 and MMP-9 enzyme activity on wound healing, tumor growth and RACPP cleavage. PLoS One 2018;13(9):e0198464. PMCID: PMC6152858 Biosciences, which has licensed the ACPP technology from the University of California Regents. This affiliation does not alter our adherence to PLOS ONE policies on sharing data and materials. The remaining authors declare that they have no other competing interests.

Holland ND. Formation of the initial kidney and mouth opening in larval amphioxus studied with serial blockface scanning electron microscopy (SBSEM). Evodevo 2018;9:16. PMCID: PMC6013890.

Hu M, Dailamy A, Lei XY, Parekh U, McDonald D, Kumar A, Mali P. Facile Engineering of Long-Term Culturable Ex Vivo Vascularized Tissues Using Biologically Derived Matrices. Adv Healthc Mater 2018;7(23):e1800845. PMCID: PMC6478398.

Huang ML, Michalak AL, Fisher CJ, Christy M, Smith RAA, Godula K. Small Molecule Antagonist of Cell Surface Glycosaminoglycans Restricts Mouse Embryonic Stem Cells in a Pluripotent State. Stem Cells 2018;36(1):45-54. PMCID: PMC6237099.

Kalyanaraman H, Schwaerzer G, Ramdani G, Castillo F, Scott BT, Dillmann W, Sah RL, Casteel DE, Pilz RB. Protein Kinase G Activation Reverses Oxidative Stress and Restores Osteoblast Function and Bone Formation in Male Mice With Type 1 Diabetes. Diabetes 2018;67(4):607-23. PMCID: PMC5860855.

Kyriakakis P, Catanho M, Hoffner N, Thavarajah W, Hu VJ, Chao SS, Hsu A, Pham V, Naghavian L, Dozier LE, Patrick GN, Coleman TP. Biosynthesis of Orthogonal Molecules Using Ferredoxin and Ferredoxin-NADP(+) Reductase Systems Enables Genetically Encoded PhyB Optogenetics. ACS Synth Biol 2018;7(2):706-17. PMCID: PMC5820651.

Lagarrigue F, Gingras AR, Paul DS, Valadez AJ, Cuevas MN, Sun H, Lopez-Ramirez MA, Goult BT, Shattil SJ, Bergmeier W, Ginsberg MH. Rap1 binding to the talin 1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation. Blood Adv 2018;2(18):2358-68. PMCID: PMC6156890.

Loureiro ME, Zorzetto-Fernandes AL, Radoshitzky S, Chi X, Dallari S, Marooki N, Leger P, Foscaldi S, Harjono V, Sharma S, Zid BM, Lopez N, de la Torre JC, Bavari S, Zuniga E. DDX3 suppresses type I interferons and favors viral replication during Arenavirus infection. PLoS Pathog 2018;14(7):e1007125. PMCID: PMC6042795.

Ma X, Yu C, Wang P, Xu W, Wan X, Lai CSE, Liu J, Koroleva-Maharajh A, Chen S. Rapid 3D bioprinting of decellularized extracellular matrix with regionally varied mechanical properties and biomimetic microarchitecture. Biomaterials 2018;185:310-21. PMCID: PMC6186504.

Maricic I, Marrero I, Eguchi A, Nakamura R, Johnson CD, Dasgupta S, Hernandez CD, Nguyen PS, Swafford AD, Knight R, Feldstein AE, Loomba R, Kumar V. Differential Activation of Hepatic Invariant NKT Cell Subsets Plays a Key Role in Progression of Nonalcoholic Steatohepatitis. J Immunol 2018;201(10):3017-35. PMCID: PMC6219905.

Marin-Valencia I, Novarino G, Johansen A, Rosti B, Issa MY, Musaev D, Bhat G, Scott E, Silhavy JL, Stanley V, Rosti RO, Gleeson JW, Imam FB, Zaki MS, Gleeson JG. A homozygous founder mutation in TRAPPC6B associates with a neurodevelopmental disorder characterised by microcephaly, epilepsy and autistic features. J Med Genet 2018;55(1):48-54. PMCID: PMC6056005.

McCall LI, Tripathi A, Vargas F, Knight R, Dorrestein PC, Siqueira-Neto JL. Experimental Chagas disease-induced perturbations of the fecal microbiome and metabolome. PLoS Negl Trop Dis 2018;12(3):e0006344. PMCID: PMC5864088.

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