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Publications

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Selected Publications

2018

  • Chen M, Geoffroy CG, Meves JM, et al. Leucine Zipper-Bearing Kinase Is a Critical Regulator of Astrocyte Reactivity in the Adult Mammalian CNS. Cell Rep. 2018;22(13):3587-3597.
  • Narang A, Zheng B. To Scar or Not to Scar. Trends Mol Med. 2018;24(6):522-524.
  • Meves JM, Geoffroy CG, Kim ND, Kim JJ, Zheng B. Oligodendrocytic but not neuronal Nogo restricts corticospinal axon sprouting after CNS injury. Exp Neurol. 2018;309:32-43.

2017

  • Geoffroy CG, Meves JM, Zheng B. (2017). The age factor in axonal repair after spinal cord injury: A focus on neuron-intrinsic mechanisms. Neurosci. Lett. pii: S0304-3940(16)30842-4.

2016

  • Meves JM, Zheng B. (2016). Synaptic Suppression of Axon Regeneration. Neuron 92, 267-269.
  • Chen M, Geoffroy CG, Wong HN, Tress O, Nguyen MT, Holzman LB, Jin Y, Zheng B. (2016). Leucine Zipper-bearing Kinase promotes axon growth in mammalian central nervous system neurons. Sci. Rep. 6, 31482.
  • Geoffroy CG, Hilton BJ, Tetzlaff W, Zheng B. (2016). Evidence for an Age-Dependent Decline in Axon Regeneration in the Adult Mammalian Central Nervous System. Cell Rep. 2016 Apr 12;15(2):238-46.

2015

  • Lorenzana, A. O., Lee, J. K., Mui, M., Chang, A., & Zheng, B. (2015). A surviving intact branch stabilizes remaining axon architecture after injury as revealed by in vivo imaging in the mouse spinal cord. Neuron 86, 947-54.
  • Geoffroy, C. G., Lorenzana, A. O., Kwan, J. P., Lin, K., Ghassemi, O., Ma, A., Xu, N., Creger, D., Liu, K., He, Z., and Zheng, B. (2015). Effects of PTEN and Nogo Codeletion on Corticospinal Axon Sprouting and Regeneration in Mice. J. Neurosci. 35, 6413-28.

2014

  • Chen, M., and Zheng, B. (2014). Axon plasticity in the mammalian central nervous system after injury. Trends Neurosci. 37, 583-93.
  • Meves J. M. and Zheng, B. (2014). Extrinsic inhibitors in axon sprouting and functional recovery after spinal cord injury. Neural Regen. Res. 9, 460-1.
  • Lemmon et al. (2014). Minimum Information About a Spinal Cord Injury Experiment (MIASCI) - a proposed reporting standard for spinal cord injury experiments. J. Neurotrauma 31, 1354-61.
  • Geoffroy, C. G. and Zheng, B. (2014). Myelin-associated inhibitors in axonal growth after CNS injury. Curr. Opin. Neurobiol. 27, 31-8.
  • Zheng, B. and Fouad, K. (2014). Myelin-associated axon growth inhibitors. In Textbook of Neural Repair & Rehabilitation, Volume I - Neural Repair and Plasticity. M. Selzer, S. Clarke, L. Cohen, G. Kwakkel, and R. Miller, eds. pp. 339-48. Cambridge University Press.

2012

  • Lu, P., Wang, Y., Graham, L., McHale, K., Gao, M., Wu, D., Brock, J., Blesch, A., Rosenzweig, E. S., Havton, L. A., Zheng, B., Conner, J. M., Marsala, M., Tuszynski, M. H. (2012). Long-distance growth and connectivity of neural stem cells after severe spinal cord injury: Cell-intrinsic mechanisms overcome spinal inhibition. Cell 150, 1264-73.
  • Dudanova, I., Kao, T. J., Herrmann, J. E., Zheng, B., Kania, A., Klein, R. (2012). Genetic evidence for a contribution of EphA:ephrinA reverse signaling to motor axon guidance. J. Neurosci. 32, 5209-15.
  • Dickendesher, T. L., Baldwin, K. T., Mironova, Y. A., Koriyama, Y., Raiker, S. J., Askew, K. L., Wood, A., Geoffroy, C. G., Zheng, B., Liepmann, C. D., Katagiri, Y., Benowitz, L. I., Geller, H. M., Giger, R. J. (2012). NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans. Nat. Neurosci. 15, 703-12.

2011

  • Chong, S. Y., Rosenberg, S. S., Fancy, S. P., Zhao, C., Shen, Y. A., Hahn, A. T., McGee, A. W., Xu, X., Zheng, B., Zhang, L. I., Rowitch, D. H., Franklin, R. J., Lu, Q. R., Chan, J. R. (2011). Neurite outgrowth inhibitor Nogo-A establishes spatial segregation and extent of oligodendrocyte myelination. Proc. Natl. Acad. Sci. USA. 109, 1299-304.
  • Ruby, K. M. and Zheng, B. (2011). Genetic engineering of human embryonic stem cells: focusing on targeted modification. In Stem Cell Bioengineering and Tissue Engineering Microenvironment. S. Prakash and D. Shum-Tim, eds. pp. 231-51. World Scientific Publishing Company.
  • Wang, L., Klein, R., Zheng, B., Marquardt, T. (2011). Anatomical Coupling of Sensory and Motor Nerve Trajectory via Axon Tracking. Neuron 71, 263-77.
  • Lee, J. K, and Zheng, B. (2011). Role of myelin-associated inhibitors in axonal repair after spinal cord injury. Exp Neurol. 235, 33-42.

2010

  • Lee, J. K., Chow, R., Xie, F., Chow, S. Y., Tolentino, K. E., and Zheng, B. (2010). Combined genetic attenuation of myelin and Semaphorin-mediated growth inhibition is insufficient to promote serotonergic axon regeneration. J. Neurosci. 30, 10899-10904.
  • Liu, K., Lu, Y., Lee, J. K., Samara, R., Willenberg, R., Sears-Kraxberger, I., Tedeschi, A., Park, K. K., Jin, D., Cai, B., Xu, B., Connolly, L., Steward, O., Zheng, B., and He, Z. (2010). PTEN deletion enhances the regenerative ability of adult corticospinal neurons. Nat. Neurosci. 13, 1075-1081.
  • Lee, J. K., Geoffroy, C. G., Chan, A. F., Tolentino, K. E., Crawford, M. J., Leal, M. A., Kang, B., and Zheng, B. (2010). Assessing spinal axon regeneration and sprouting in Nogo-, MAG-, and OMgp-deficient mice. Neuron 66, 663-670.
  • Hollis, E. R. 2nd, Jamshidi, P., Lorenzana, A. O., Lee, J. K., Gray, S. J., Samulski, R. J., Zheng, B., Tuszynski, M. H. (2010). Transient demyelination increases the efficiency of retrograde AAV transduction. Mol. Ther. 18, 1496-1500.
  • Masliah, E., Xie, F., Dayan, S., Rockenstein, E., Mante, M., Adame, A., Patrick, C. M., Chan, A. F., Zheng, B. (2010). Genetic deletion of Nogo/Rtn4 ameliorates behavioral and neuropathological outcomes in amyloid precursor protein transgenic mice. Neuroscience 169, 488-494.
  • Herrmann, J. E., Shah, R. R., Chan, A. F., and Zheng, B. (2010). EphA4 deficient mice maintain astroglial-fibrotic scar formation after spinal cord injury. Exp. Neurol. 223, 582-598.
  • Herrmann, J. E., Pence, M. A., Shapera, E. A., Shah, R. R., Geoffroy, C. G., and Zheng, B. (2010). Generation of an EphA4 conditional allele in mice. Genesis 48, 101-105.
  • Gil, V., Bichler, Z., Lee, J. K., Seira, O., Llorens, F., Bribian, A., Morales, R., Claverol-Tinture, E., Soriano, E., Sumoy, L., Zheng, B., Del Río, J. A. (2010). Developmental Expression of the Oligodendrocyte Myelin Glycoprotein in the Mouse Telencephalon. Cereb Cortex 20, 1769-1779.

2009

  • Lee, J. K.*, Case, L. C.*, Chan, A. F., Zhu, Y., Tessier-Lavigne, M., and Zheng, B. (2009). Generation of an OMgp allelic series in mice. Genesis 47, 751-6. *Equal contributors.
  • Lee, J. K, Chan, A. F., Luu, S. M., Zhu, Y, Ho, C., Tessier-Lavigne, M., and Zheng, B. (2009). Reassessment of corticospinal tract regeneration in Nogo deficient mice. J. Neurosci. 29, 8649-54.
  • Ruby, K. M, and Zheng, B. (2009). Gene targeting in a HUES line of human embryonic stem cells via electroporation. Stem Cells 27, 1496-506.

2008

  • Steward, O., Zheng, B., Tessier-Lavigne, M., Hofstadter, M., Sharp, K., Yee, K.M. (2008). Regenerative growth of corticospinal tract axons via the ventral column after spinal cord injury in mice. J. Neurosci. 28, 6836-47.
  • Lee, J. K., and Zheng, B. (2008). Axon regeneration aft er spinal cord injury: insight from genetically modified mouse models. Rest. Neurol. Neurosci. 26, 175-82.
  • Davalos, D.*, Lee, J. K.*, Smith, W. B., Brinkman, B., Ellisman, M. H., Zheng, B., and Akassoglou, K. (2008). Stable in vivo imaging of densely populated glia, axons and blood vessels in the mouse spinal cord using two-photon microscopy. J Neurosci Methods 169, 1-7. * Equal contributors.
  • Xie, F., and Zheng, B. (2008). White matter inhibitors in CNS axon regeneration failure. Exp. Neurol. 209, 302-12.

2007

  • Schachtrup, C., Lu, P., Jones, L. L., Lee, J. K., Lu, J., Sachs, B. D., Zheng, B. and Akassoglou, K. (2007). Fibrinogen inhibits neurite outgrowth via beta3 integrin-mediated phosphorylation of the EGF receptor. Proc. Natl. Acad. Sci. USA. 104, 11814-9.
  • Steward, O., Zheng, B., Banos, K., and Yee, K. M. (2007). Response to: Kim et al., "Axon Regeneration in Young Adult Mice Lacking Nogo-A/B." Neuron 38, 187-199. Neuron 54, 191-5.
  • Mingorance-Le Meur, A., Zheng, B., Soriano, E., and Del Rio, J. A. (2007). Involvement of the Myelin-Associated Inhibitor Nogo-A in Early Cortical Development and Neuronal Maturation. Cereb. Cortex 17, 2375-86.
  • Yaron, A, and Zheng, B. (2007). Navigating their way to the clinic: emerging roles for axon guidance molecules in neurological disorders and injury. Dev. Neurobiol. 67, 1216-31.

2006

  • Zheng, B., Lee, J. K., and Xie, F. (2006). Genetic mouse models for studying inhibitors of spinal axon regeneration. Trends in Neurosci. 29, 640-6.

2005

  • Anderson, D. K, Beattie, M., Blesch, A., Bresnahan, J., Bunge, M., Dietrich, D., Dietz, V., Dobkin, B., Fawcett, J., Fehlings, M., Fischer, I., Grossman, R., Guest, J., Hagg, T., Hall, E. D., Houle, J., Kleitman, N., McDonald, J., Murray, M., Privat, A., Reier, P., Steeves, J., Steward, O., Tetzlaff, W., Tuszynski, M. H., Waxman, S. G., Whittemore, S., Wolpaw, J., Young, W., Zheng, B. (2005). Recommended guidelines for studies of human subjects with spinal cord injury. Spinal Cord 43, 453-8.

Binhai's Publications 2003 - 2005 (selected)

  • Zheng, B.*, Atwal, J.*, Ho, C., Case, L., He, X. L., Garcia, K. C., Steward, O., and Tessier-Lavigne, M. (2005). Genetic deletion of Nogo Receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo. Proc. Natl. Acad. Sci. USA. 102, 1205-10. * Equal contributors.
  • Fontoura, P., Ho, P. P., DeVoss, J., Zheng, B., Lee, B. J., Kidd, B. A., Garren, H., Sobel, R. A., Robinson, W. H., Tessier-Lavigne, M., Steinman, L. (2004). Immunity to the extracellular domain of Nogo-A modulates experimental autoimmune encephalomyelitis. J. Immunol. 173, 6981-92.
  • Steward, O., Zheng, B., Ho, C., Anderson, K., and Tessier-Lavigne, M. (2004). The dorsolateral corticospinal tract in mice: an alternative route for corticospinal input to caudal segments following dorsal column lesions. J. Comp. Neurol. 472, 463-77.
  • Karnezis, T., Mandemakers, W., McQualter, J. L., Zheng, B., Ho., P. P., Jordan, K. A., Murray, B. M., Barres, B., Tessier-Lavigne, M., Bernard, C. C. (2004). The neurite outgrowth inhibitor Nogo A is involved in autoimmune-mediated demyelination. Nat. Neurosci. 7, 736-44.
  • Zheng, B., Ho, C., Li, S., Keirstead, H., Steward, O., and Tessier-Lavigne, M. (2003). Lack of enhanced spinal regeneration in Nogo-deficient mice. Neuron 38, 213-24.
  • Steward, O., Zheng, B., and Tessier-Lavigne, M. (2003). False resurrections: distinguishing regenerated from spared axons in the injured central nervous system. J. Comp. Neurol. 459, 1-8.

Binhai's Publications prior to 2003 (selected)

  • Zheng, B., Vogel, H., Donehower, L. A., and Bradley, A. (2002). Visual genotyping of a coat color tagged p53 mutant mouse line. Cancer Biol. Ther. 1, 433-5.
  • Cleary, M. A., van Raamsdonk, C. D., Levorse, J., Zheng, B., Bradley, A., and Tilghman, S. M. (2001). Disruption of an imprinted gene cluster by a targeted chromosomal translocation in mice. Nat. Genet. 29, 78-82.
  • Zheng, B., Albrecht, U., Kaasik, K., Sage, M., Lu, W., Vaishnav, S., Li, Q., Sun, Z. S., Eichele, G., Bradley, A., and Lee, C. C. (2001). Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock. Cell 105, 683-94.
  • Zheng, B., Mills, A. A., and Bradley, A. (2001). Introducing defined chromosomal rearrangements into the mouse genome. Methods 24, 81-94.
  • Shearman, L. P., Sriram, S., Weaver, D. R., Maywood, E. S., Chaves, I., Zheng, B., Kume, K., Lee, C. C., van der Horst, G. T., Hastings, M. H., and Reppert, S. M. (2000). Interacting molecular loops in the mammalian circadian clock. Science 288, 1013-9.
  • Zheng, B., Sage, M., Sheppeard, E. A., Jurecic, V., and Bradley, A. (2000). Engineering mouse chromosomes with Cre-loxP: range, efficiency, and somatic applications. Mol. Cell. Biol. 20, 648-55.
  • Zheng, B., Sage, M., Cai, W. W., Thompson, D. M., Tavsanli, B. C., Cheah, Y. C., and Bradley, A. (1999). Engineering a mouse balancer chromosome. Nat. Genet. 22, 375-8.
  • Zheng, B., Larkin, D. W., Albrecht, U., Sun, Z. S., Sage, M., Eichele, G., Lee, C. C., and Bradley, A. (1999). The mPer2 gene encodes a functional component of the mammalian circadian clock. Nature 400, 169-73.
  • Zheng, B., Mills, A. A., and Bradley, A. (1999). A system for rapid generation of coat color-tagged knockouts and defined chromosomal rearrangements in mice. Nucleic Acids Res. 27, 2354-60.
  • Mills, A. A., Zheng, B., Wang, X. J., Vogel, H., Roop, D. R., and Bradley, A. (1999). p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 398, 708-13.
  • Prolla, T. A., Baker, S. M., Harris, A. C., Tsao, J. L., Yao, X., Bronner, C. E., Zheng, B., Gordon, M., Reneker, J., Arnheim, N., Shibata, D., Bradley, A., and Liskay, R. M. (1998). Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair. Nat. Genet. 18, 276-9.