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Publications

2020
Yang W, Sung K, Xu W, Rodriguez MJ, Wu AC, Santos SA, Fang S, Uber RK, Dong SX, Guillory BC, Orain X, Raus J, Jolivalt C, Calcutt N, Rissman RA, Ding J, Wu C. A Missense Point Mutation in Nerve Growth Factor (NGFR100W) Results in Selective Peripheral Sensory Neuropathy. Prog Neurobiol2020 Jul 18;:101886doi: 10.1016/j.pneurobio.2020.101886. [Epub ahead of print] PubMed PMID: 32693191.

​Ruinan Shen; Xiaobei Zhao; Lu He; Yongbo Ding; Wei Xu; Suzhen Lin; Savannah Fang; Wanlin Yang; Kijung Sung; Brian Spencer; Robert A Rissman; Ming Lei; Jianqing Ding; Chengbiao Wu. Upregulation of RIN3 induces endosomal dysfunction in Alzheimer’s disease. Transl Neurodegener2020 Jun 18;9(1):26doi: 10.1186/s40035-020-00206-1. PubMed PMID: 32552912; PubMed Central PMCID: PMC7301499.Accepted for Translational Neurodegeneration

Li R, Li D, Wu C, Ye L, Wu Y, Yuan Y, Yang S, Xie L, Mao Y, Jiang T, Li Y, Wang J, Zhang H, Li X, Xiao J. Nerve growth factor activates autophagy in Schwann cells to enhance myelin debris clearance and to expedite nerve regeneration. Theranostics. 2020;10(4):1649-1677. doi: 10.7150/thno.40919. eCollection 2020. PubMed PMID: 32042328; PubMed Central PMCID: PMC6993217.
2019

​Wenzel ED, Speidell A, Flowers SA, Wu C, Avdoshina V, Mocchetti I. Histone deacetylase 6 inhibition rescues axonal transport impairments and prevents the neurotoxicity of HIV-1 envelope protein gp120. Cell Death Dis. 2019 Sep 12;10(9):674. doi: 10.1038/s41419-019-1920-7. PubMed PMID: 31515470; PubMed Central PMCID: PMC6742654.

Bearer EL, Wu C. Herpes Simplex Virus, Alzheimer's Disease and a Possible Role for Rab GTPases. Front Cell Dev Biol. 2019;7:134. doi: 10.3389/fcell.2019.00134. eCollection 2019. PubMed PMID: 31448273; PubMed Central PMCID: PMC6692634.

Escudero CA, Cabeza C, Moya-Alvarado G, Maloney MT, Flores CM, Wu C, Court FA, Mobley WC, Bronfman FC. c-Jun N-terminal kinase (JNK)-dependent internalization and Rab5-dependent endocytic sorting mediate long-distance retrograde neuronal death induced by axonal BDNF-p75 signaling. Sci Rep. 2019 Apr 15;9(1):6070. doi: 10.1038/s41598-019-42420-6. PubMed PMID: 30988348; PubMed Central PMCID: PMC6465280.

Sung K, Yang W, Wu C. Uncoupling neurotrophic function from nociception of nerve growth factor: what can be learned from a rare human disease?. Neural Regen Res. 2019 Apr;14(4):570-573. doi: 10.4103/1673-5374.247442. Review. PubMed PMID: 30632491; PubMed Central PMCID: PMC6352596.

Yang W, Sung K, Zhou F, Xu W, Rissman RA, Ding J, Wu C. Targeted Mutation (R100W) of the Gene Encoding NGF Leads to Deficits in the Peripheral Sensory Nervous System. Front Aging Neurosci. 2018;10:373. doi: 10.3389/fnagi.2018.00373. eCollection 2018. PubMed PMID: 30524266; PubMed Central PMCID: PMC6262302.

Chen XQ, Fang F, Florio JB, Rockenstein E, Masliah E, Mobley WC, Rissman RA, Wu C. T-complex protein 1-ring complex enhances retrograde axonal transport by modulating tau phosphorylation. Traffic. 2018 Nov;19(11):840-853. doi: 10.1111/tra.12610. Epub 2018 Sep 12. PubMed PMID: 30120810; PubMed Central PMCID: PMC6191364.select

2018

Sung K, Ferrari LF, Yang W, Chung C, Zhao X, Gu Y, Lin S, Zhang K, Cui B, Pearn ML, Maloney MT, Mobley WC, Levine JD, Wu C. Swedish Nerve Growth Factor Mutation (NGFR100W) Defines a Role for TrkA and p75NTR in Nociception. J Neurosci. 2018 Apr 4;38(14):3394-3413. doi: 10.1523/JNEUROSCI.1686-17.2018. Epub 2018 Feb 26. PubMed PMID: 29483280; PubMed Central PMCID: PMC5895035.

Pearn ML, Schilling JM, Jian M, Egawa J, Wu C, Mandyam CD, Fannon-Pavlich MJ, Nguyen U, Bertoglio J, Kodama M, Mahata SK, DerMardirossian C, Lemkuil BP, Han R, Mobley WC, Patel HH, Patel PM, Head BP. Inhibition of RhoA reduces propofol-mediated growth cone collapse, axonal transport impairment, loss of synaptic connectivity, and behavioural deficits. Br J Anaesth. 2018 Apr;120(4):745-760. doi: 10.1016/j.bja.2017.12.033. Epub 2018 Feb 15. PubMed PMID: 29576115.

Xu W, Fang F, Ding J, Wu C. Dysregulation of Rab5-mediated endocytic pathways in Alzheimer's disease. Traffic. 2018 Apr;19(4):253-262. doi: 10.1111/tra.12547. Epub 2018 Feb 5. Review. PubMed PMID: 29314494; PubMed Central PMCID: PMC5869093.

Mo Z, Zhao X, Liu H, Hu Q, Chen XQ, Pham J, Wei N, Liu Z, Zhou J, Burgess RW, Pfaff SL, Caskey CT, Wu C, Bai G, Yang XL. Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy. Nat Commun. 2018 Mar 8;9(1):1007. doi: 10.1038/s41467-018-03461-z. PubMed PMID: 29520015; PubMed Central PMCID: PMC5843656.

2017


Bett C, Lawrence J, Kurt TD, Orru C, Aguilar-Calvo P, Kincaid AE, Surewicz WK, Caughey B, Wu C, Sigurdson CJ. Enhanced neuroinvasion by smaller, soluble prions. Acta Neuropathol Commun. 2017 Apr 21;5(1):32. doi: 10.1186/s40478-017-0430-z.

Liu H, Wu C. Charcot Marie Tooth 2B Peripheral Sensory Neuropathy: How Rab7 Mutations Impact NGF Signaling? Int J Mol Sci. 2017 Feb 4;18(2). pii: E324. doi: 10.3390/ijms18020324. Review.

Plotkin JL, Wu C. Neurotrophin biology at NGF 2016: From fundamental science to clinical applications. Int J Dev Neurosci. 2017 Feb;56:27-34. doi: 10.1016/j.ijdevneu.2016.11.005. Epub 2016 Nov 22. Review.