Research Interests: Axons are the primary target in many neurodegenerative diseases associated with both the central and peripheral nervous system. Dysfunction and degeneration of axons i.e. axonopathy, is often the earliest sign of neurodegeneration. We use molecular, cellular, biochemical, and imaging methods to investigate the cellular and molecular mechanisms of axonopathy and neurodegeneration. Our ultimate goal is to understand how impairment of axonal functions leads to neurodegenerative diseases such as Alzheimer’s disease (AD), Tauopathies, Huntington’s disease (HD), Down syndrome (DS), and Charcot-Marie-Tooth 2B (CMT2B) peripheral sensory neuropathy.