The overarching idea is that activation of different neuronal cell types has different signatures in the evoked CBF (ΔF), CMRO2 (ΔC), and the macroscopic current dipole responses (ΔD), and by measuring these responses noninvasively in the human brain we will be able to probe more deeply the underlying cellular and circuit activity.
For each neuronal population (e.g., excitatory and inhibitory), the current dipole moment (measured by MEG) and CBF/CMRO2 (measured by calibrated BOLD) can be expressed as convolution of the neuronal activity for neuronal population of cell type j with time-resolved weighting factor W(t) for that cell type (that can be thought of as cell-type-specific impulse response function, IRF). The weighting factors W(t) will be determined experimentally using selective optogenetic activation of specific cell types in mice. Read more about these ideas here.
This project combines data acquisition in mice and humans with computational modeling.