Publications

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2018

Faget L, Zell V, Souter, E, McPherson A, Ressler, R, Gutierrez-Reed N, Yoo JH, Dulcis D, Hnasko TS. Opponent control of behavioral reinforcement by inhibitory and excitatory projections from the ventral pallidum. Nature Communications. Nature Communications

Steinkellner T, Zell V, Farino ZJ, Sonders MS, Villeneuve M, Freyberg RJ, Przedborski S, Lu W, Freyberg Z, Hnasko TS. Role for VGLUT2 in selective vulnerability of midbrain dopamine neurons. Journal of Clinical Investigation.

2017

Fife HA, Gutierrez-Reed NA, Zell V, Bailly J, Lewis C, Aron AR, Hnasko TS. Causal role for the subthalamic nucleus in interrupting behavior. eLIFE.

Wang DV, Viereckel T, Konradsson-Geuken A, Broker CJ, Talishinsky A, Yoo JH, Galinato MH, Arvidsson E, Hnasko TS, Wallén-Mackenzie A, Ikemoto S. Glutamate co-transmission does not potentiate acquisition of conditioned behavior reinforced by dopamine neuron activation. Cell Reports.

Hutchison MA, Gu X, Adrover MF, Lee MR, Hnasko TS, Alvarez VA, Lu W.  Genetic inhibition of neurotransmission reveals role of glutamatergic input to dopamine neurons in high effort behavior. Molecular Psychiatry.

Yoo JH, Zell V, Wu J, Punta C, Ramajayam N, Shen X, Lilascharoen V, Lim BK, Hnasko TS.  Activation of pedunculopontine glutamate neurons is reinforcing. Journal of Neuroscience.

2016

Yoo JH*, Zell V*, Gutierrez-Reed N, Wu J, Ressler R, Shenasa MA, Johnson AB, Fife KH, Faget L, Hnasko TS.  Ventral tegmental area glutamate neurons co-release GABA and promote positive reinforcement.  Nature Communications

Faget L, Osakada F, Duan J, Ressler R, Johnson AB, Yoo JH, Proudfoot JA, Callaway EM, Hnasko TS. Afferent inputs to neurotransmitter-defined cell types in the ventral tegmental area.  Cell Reports

Soden ME, Miller SM, Burgeno LM, Phillips PEM, Hnasko TS, Zweifel LS.  Genetic isolation of hypothalamic neurons that regulate context-specific male social behavior.  Cell Reports.

Berland C, Cansell C, Hnasko TS, Magnan C, Luquet S.  Dietary triglycerides as signaling molecules that influence reward and motivation.  Current Opinion in Behavioral Sciences

2015
Cheung CC, Krause WC, Edwards RH, Yang CF, Shah NM, Hnasko TS, Ingraham HA.  Sex-dependent changes in metabolism and behavior, as well as reduced anxiety after eliminating ventromedial hypothalamus excitatory output. Molecular Metabolism.

Denis RG, Joly-Amado A, Webber E, Langlet F, Schaeffer M, Padilla SL, Cansell C, Dehouck B, Castel J, Delbès AS, Martinez S, Lacombe A, Rouch C, Kassis N, Fehrentz JA, Martinez J, Verdié P, Hnasko TS, Palmiter RD, Krashes MJ, Güler AD, Magnan C, Luquet S.  Palatability Can Drive Feeding Independent of AgRP Neurons. Cell Metabolism.

2014

Berthet A, Margolis EB, Zhang J, Hsieh I, Zhang J, Hnasko TS, Ahmad J, Edwards RH, Sesaki H, Huang EJ, Nakamura K.  Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons. Journal of Neuroscience.

Trudeau LE, Hnasko TS, Wallén-Mackenzie A, Morales M, Rayport S, Sulzer D.  The multilingual nature of dopamine neurons. Progress in Brain Research.

Cansell C, Castel J, Denis RG, Rouch C, Delbes AS, Martinez S, Mestivier D, Finan B, Maldonado-Aviles JG, Rijnsburger M, Tschöp MH, Dileone RJ, Eckel RH, la Fleur SE, Magnan C, Hnasko TS, Luquet S.  Dietary triglycerides act on mesolimbic structures to regulate the rewarding and motivational aspects of feeding. Molecular Psychiatry.

2013

Delwig A, Majumdar S, Ahern K, LaVail MM, Edwards RH, Hnasko TS, Copenhagen DR.  Glutamatergic neurotransmission from melanopsin retinal ganglion cells is required for neonatal photoaversion but not adult pupillary light reflex.  PLOS One, 8:e83974 (2013).  PMID: 24391855

Li H, Fertuzinhos S, Mohns E, Hnasko TS, Edwards RH, Sestan N, Crair MC. Laminar and columnar development of barrel cortex relies on thalamocortical neurotransmission. Neuron, 79:970-86 (2013). PMID: 24012009

Bui TV, Akay T, Loubani O, Hnasko TS, Jessell TM, Brownstone RM. Circuits for grasping: spinal dI3 interneurons mediate cutaneous control of motor behavior. Neuron, 78:191-204 (2013).  PMID: 23583114

2012

Hnasko TS, Hjelmstad GO, Fields HL, Edwards RH. Ventral Tegmental Area Glutamate Neurons: Electrophysiological Properties and Projections. The Journal of Neuroscience 32:15076-85 (2012). PDF

Hnasko TS, Edwards RH. Neurotransmitter co-release: mechanism and physiological role. Annual Reviews in Physiology 74:225-43 (2012). PDF

2011

Talapor AE, Endo T, Low P, Borgius L, Hagglund M, Dougherty KJ, Ryge J, Hnasko TS, Kiehn O. Identification of minimal neuronal networks involved in flexor-extensor alternation in the mammalian spinal cord. Neuron 71:1071-84 (2011).  PMID: 21943604

Goh GY, Huang H, Ullman J, Borre L, Hnasko TS, Trussell LO, Edwards RH. Presynaptic regulation of quantal size: K+/H+ exchange stimulates vesicular glutamate transport. Nature Neuroscience, 14:1285-92 (2011). PDF

Koch SM, Dela Cruz SG, Hnasko TS, Edwards RH, Huberman AD, Ullian EM. Pathway-specific genetic attenuation of glutamate release alters select features of competition-based visual circuit refinement. Neuron, 71:235-42 (2011). PDF

2010

Scherrer G, Low SA, Wang X, Zhang J, Yamanaka H, Urban R, Hnasko TS, Edwards RH, Basbaum AI. VGLUT2 expression in primary afferent neurons is essential for normal acute pain and heat hypersensitivity following peripheral injury. Proceedings of the National Academy of Sciences USA107:22296-01 (2010). PDF

*Stuber G, *Hnasko TS, Britt J, Edwards RH, Bonci A. Dopaminergic terminals in the nucleus accumbens but not the dorsal striatum co-release glutamate. Journal of Neuroscience, 30:8229-33 (2010).*equal contributions PDF

Hnasko TS, Chuhma N, Zhang H, Goh GY, Sulzer D, Palmiter RD, Rayport S, Edwards RH. Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo. Neuron 65:643-56 (2010). PDF

2009

Land BB, Bruchas MR, Schattauer S, Giardino WJ, Aita M, Messinger D, Hnasko TS, Palmiter RD, Chavkin C. Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking. Proceedings of the National Academy of Sciences USA 106:19168-73 (2009). PDF

2007

*Hnasko TS, *Sotak BA, Palmiter RD. Cocaine conditioned place preference in dopamine-deficient mice is mediated by serotonin. Journal of Neuroscience 27:12484-8 (2007). *equal contributions PDF

Hnasko TS, Hnasko RM, Sotak BN, Kapur RP, Palmiter RD. Genetic disruption of dopamine production results in pituitary adenomas and severe prolactinemia. Neuroendocrinology 86:48-57 (2007). PDF

Robinson S, Rainwater AJ, Hnasko TS, Palmiter RD. Viral restoration of dopamine signaling to the dorsal striatum restores instrumental conditioning to dopamine-deficient mice. Psychopharmacology 191:567-78 (2007). PDF

2006

Hnasko TS, Perez FA, Scouras A, Stoll EA, Luquet S, Gale SD, Phillips PE, Kremer EJ, Palmiter RD. Cre-recombinase mediated restoration of dopamine production to the dorsal striatum results in hyperphagia and hyperactivity. Proceedings of the National Academy of Sciences USA 103:8858-63 (2006). PDF

2005

Hnasko TS, Sotak BA, Palmiter RD. Morphine reward in dopamine-deficient mice. Nature438:854-7 (2005). PDF

Luquet S, Perez FA, Hnasko TS, Palmiter RD. NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science 310:683-5 (2005). PDF

Sotak BA, Hnasko TS, Robinson S, Kremer EJ, Palmiter RD. Dysregulation of dopamine signaling in the dorsal striatum inhibits feeding. Brain Research 1061:88-96 (2005). 

2004

Hnasko TS, Szczypka MS, Alaynick WA, During MJ, Palmiter RD. A role for dopamine in feeding responses produced by orexigenic agents. Brain Research 1023:309-318 (2004). 

2003

Heusner CA, Hnasko TS, Szczypka MS, Liu Y, During MJ, Palmiter RD. Viral restoration of dopamine to the nucleus accumbens is sufficient to induce a locomotor response to amphetamine. Brain Research 980:266-274 (2003).