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Research Studies: Progressive Supranuclear Palsy

Currently enrolling studies:

Four Repeat Tauopathy Neuroimaging Initiative (4RTNI-2)

  • This study is investigating the best method of analysis to track patients with corticobasal syndrome (CBS), corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), and oligo- or variant-progressive supranuclear palsy (o/vPSP). The results will provide information about the value of novel imaging techniques for diagnosis and value of novel imaging techniques in comparison to biofluid biomarkers.
  • The study will collect detailed clinical information, biofluids, and imaging data from individuals with corticobasal degeneration and progressive supranuclear palsy. There will be one visit every six months for a year (a total of three visits over one year). Oligo- or variant- progressive supranuclear palsy, and healthy participants will be asked for an additional visit approximately one year after the third visit (adding up to four visits over two years). A study partner/caregiver is required.

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

  • This is a 5-year longitudinal investigating the best method of analysis to track patients with corticobasal syndrome (CBS), corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), behavioral variant of frontotemporal degeneration (bvFTD), primary progressive aphasia (PPA), and other forms of frontotemporal lobar degeneration with the overall goal to prepare for treatment trials. The study will track familial FTD, sporadic FTD as well as asymptomatic participants with a strong history of familial FTD. The results will provide information about the value of novel imaging techniques for diagnosis and value of novel imaging techniques in comparison to biofluid biomarkers.
  • The study will collect detailed clinical information, biofluids, and imaging data from participants at baseline and every year after that for 4 years or until the study concludes. A study partner/caregiver is required.

WMMS: Development of a Wearable Multi-Modal Monitoring System (WMMS) to determine causes of Falls in Parkinson's Disease and Atypical Parkinsonian Disorders

  • The aim of this study is to develop and test clinical applications of a wearable device that will continuously record multiple physiologic parameters such as blood pressure, heart rate, motion, brain activity etc. in patient's real life settings.
  • This study is recruiting participants with Parkinson's disease and Aypical Parkinsonian Disorders such as Progressive Supranuclear Palsy (PSP), Corticobasal Syndrome (CBS), Corticobasal Degeneration (CBD) and Multiple System Atrophy (MSA) 

NIO752: A randomized, participants, investigator, sponsor blinded, placebo-controlled study of intrathecally administered NIO752 in participants with progressive supranuclear palsy.

  • The main purpose of study is to evaluate the safety, tolerability and pharmacokinetics of multiple asdencing doses of intracethally administered NIO752.
  • Enrollment will start in late Spring 2021.


For further information about this and other studies, please contact Aishwarya Niraula by email a2niraula@health.ucsd.edu or phone 858-246-3190.