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Research Studies: Progressive Supranuclear Palsy

Currently Enrolling Studies

4-Repeat Tauopathy Neuroimaging Initiative - Cycle 2 (4RTNI-2)

  • This study is investigating the best method of analysis to track patients with corticobasal syndrome (CBS), corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), and oligo- or variant-progressive supranuclear palsy (o/vPSP). The results will provide information about the value of novel imaging techniques for diagnosis and value of novel imaging techniques in comparison to biofluid biomarkers.

  • The study will collect detailed clinical information, biofluids, and imaging data from individuals with corticobasal degeneration and progressive supranuclear palsy. There will be one visit every six months for a year (a total of three visits over one year). Oligo- or variant- progressive supranuclear palsy, and healthy participants will be asked for an additional visit approximately one year after the third visit (adding up to four visits over two years). A study partner/caregiver is required.

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

  • This is a 5-year longitudinal investigating the best method of analysis to track patients with corticobasal syndrome (CBS), corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), behavioral variant of frontotemporal degeneration (bvFTD), primary progressive aphasia (PPA), and other forms of frontotemporal lobar degeneration with the overall goal to prepare for treatment trials. The study will track familial FTD, sporadic FTD as well as asymptomatic participants with a strong history of familial FTD. The results will provide information about the value of novel imaging techniques for diagnosis and value of novel imaging techniques in comparison to biofluid biomarkers.

  • The study will collect detailed clinical information, biofluids, and imaging data from participants at baseline and every year after that for 4 years or until the study concludes. A study partner/caregiver is required.

WMMS: Development of a Wearable Multi-Modal Monitoring System (WMMS) to determine causes of Falls in Parkinson's Disease and Atypical Parkinsonian Disorders

  • The aim of this study is to develop and test clinical applications of a wearable device that will continuously record multiple physiologic parameters such as blood pressure, heart rate, motion, brain activity etc. in patient's real life settings.

  • This study is recruiting participants with Parkinson's disease and Atypical Parkinsonian Disorders such as Progressive Supranuclear Palsy (PSP), Corticobasal Syndrome (CBS), Corticobasal Degeneration (CBD) and Multiple System Atrophy (MSA)

Ongoing Studies Currently Closed to Enrollment

NIO752: A Randomized, Participants, Investigator, Sponsor Blinded, Placebo-Controlled Study of Intrathecally Administered NIO752 in Participants with Progressive Supranuclear Palsy.

  • The main purpose of study is to evaluate the safety, tolerability and pharmacokinetics of multiple ascending doses of intracethally administered NIO752.

TPN-101: A Phase 2a Study of TPN-101 in Patients with Progressive Supranuclear Palsy.

  • The study will assess the safety and tolerability of TPN-101 in people with PSP.

 

Questions?

For more information about our center's research studies, contact our Clinical Research Manager:

Jo Talledo Benrubi

atalledo@health.ucsd.edu 

(858) 246-2505

Or, movementdisorders@health.ucsd.edu