Currently enrolling studies:
ABBVIE-M15-736: Advanced Parkinson's Disease: Double-Blind, Double-Dummy, Active-Controlled, Efficacy and Safety Study of ABBV-951 Vs Oral Carbidopa/Levodopa
- This study is evaluating the efficacy and safety of ABBV-951 subcutaneous infusion to control Parkinson's disease symptoms compared to oral Carbidopa (CD)/Levodopa (LD).The study is also seeking to test whether ABBV-951 is safe and well tolerated in patients with PD over the course of 12 weeks.
- Individuals looking to participate in this study must be responsive to Carbidopa (CD)/Levodopa (LD) medications for approximately 5 years and are now experiencing a wearing "OFF" phenomena.
MARIN: A Phase 3, 22-week, Multi-center, Randomized Withdrawal Study of TD-9855 in Treating Symptomatic Neurogenic Orthostatic Hypotension in Subjects with Primary Autonomic Failure
- The main objective of this study is to evaluate the durability of effect of the study drug in subjects with symptomatic orthostatic hypotension (nOH), due to Multiple System Atrophy (MSA), Parkinson's Disease (PD), or Pure Autonomic Failure (PAF) compared with placebo (PBO).
Neurodegenerative Disorders Cerebrospinal Fluid (CSF) Biorepository
- This study is investigating potential biomarkers for Parkinsonian disorders by collecting cerebrospinal fluid, the fluid that the brain sits in. Samples may also be used for future research.
- The study will collect clinical information and cerebrospinal fluid sample from individuals with any type of Parkinsonian disorder. Non-UCSD patients will first need to be seen at UCSD to confirm the diagnosis and medical history. Participation will include one study visit to complete a lumbar puncture.
Non-Invasive Continuous Ultrasonic Blood Pressure Monitoring
- This research study is evaluating the use of continuous blood pressure monitor ultrasonic patch to learn more about orthostatic hypotension. The study is recruiting healthy volunteers and individuals with Hypotension, Prehypertension and Stage 1 or 2 hypertension.
Non-Invasive Neurophysiological Characterization of Movement Disorders
- The goal of this study is to learn more about movement disorders including tremor, Parkinson's disease, dystonia, myoclonus, neuromyotonia, ataxia, functional movement disorders, and others using non-invasive neurophysiologic techniques and clinical evaluation.
- The study also aims to teach neurologists in-training as well as other trainees in neurophysiological techniques used in the diagnosis of movement disorders.
PDGENE - Parkinson's Foundation: PDGeneration: Mapping the Future of PD
- This study is focused on assessing the impact, feasibility and participant satisfaction of offering genetic counseling as part of clinical care for people with Parkinson's Disease.
- The study will collect clinical information and blood sample from individuals with Parkinson’s disease at one visit.
WMMS: Development of a Wearable Multi-Modal Monitoring System (WMMS) to determine causes of Falls in Parkinson's Disease and Atypical Parkinsonian Disorders
- The aim of this study is to develop and test clinical applications of a wearable device that will continuously record multiple physiologic parameters such as blood pressure, heart rate, motion, brain activity etc. in patient's real life settings.
- This study is recruiting participants with Parkinson's disease and Atypical Parkinsonian Disorders such as Progressive Supranuclear Palsy (PSP), Corticobasal Syndrome (CBS), Corticobasal Degeneration (CBD) and Multiple System Atrophy (MSA)
PADOVA-BN42358: A Phase IIB, Randomized, Double-Blind, Placebo-Controlled, Multicenter study to evaluate the efficacy and safety of intravenous Parsinezumab in participants with Early Parkinson's Disease
- The study will evaluate the efficacy, safety and pharmacokinetics of prasinezumab compared with placebo in patients with early Parkinson's Disease (PD) over the course of 76 weeks with infusions occurring every 4 weeks.
- Expected to start enrollment in late Spring/early Summer 2021.
Real-Time Microneedle Sensor Monitoring of Levodopa Levels in Parkinson's disease
- The project aims to develop a continuous, minimally invasive microneedle device called the "Levodopameter" which is designed to continuously measure levodopa levels in real time, with the future goals of identifying an individualized treatment regimen for Parkinson's disease patients to improve disease management.
- This study is recruiting participants with Parkinson's disease as well as healthy volunteers.
- More information about this study can be found here: https://www.clinicaltrials.gov/ct2/show/NCT04735627
Parkinson's Outcomes Project and Patient Registry Study
- The goal of this study is to better understand Parkinson’s disease as an illness and ultimately improve the care and survival of those with the disease.
- The study will collect clinical information from individuals with Parkinson’s disease at one visit. Currently, we are only enrolling established UCSD patients.
For further information about this and other studies, please contact Aishwarya Niraula by email email@example.com or phone 858-246-3190.
MJFF Biomarker T-cell mediated autoimmune responses in PD
- The study is aimed to define the role of T Cells in Parkinson's Disease through the investigation of T cell reactivity of alpha-synuclein protein.
- The study will collect clinical information and blood sample from individuals with Parkinson’s disease and healthy volunteers. Participants will be required to come in for one visit to donate 250 mL of blood.
MJFF Minority Outreach Project an educational Tool Kit for Hispanic PD Community
- The study aimed to develop and perform qualitative interviews with Hispanic PD Patients, their caregivers, and healthcare providers serving Hispanic predominant communities in order identify their perceived barriers related to participating in PD research and their understanding of PD.
- The study is currently closed for participation. We appreciate all volunteers that were part of this study and we hope to share our published paper on this project soon.