Research Publications

These publications result from the work of our investigators.

Developmental excitatory-to-inhibitory GABA polarity switch is delayed in Ts65Dn mice, a genetic model of Down syndrome.
Lysenko LV, Kim J, Madamba F, Tyrtyshnaia AA, Ruparelia A, Kleschevnikov AM.
Neurobiol Dis. 2018 Jul;115:1-8. doi: 10.1016/j.nbd.2018.03.005. Epub 2018 Mar 14.
PMID: 29550538

Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome.
Kleschevnikov AM, Yu J, Kim J, Lysenko LV, Zeng Z, Yu YE, Mobley WC.
Neurobiol Dis. 2017 Jul;103:1-10. doi: 10.1016/j.nbd.2017.03.009. Epub 2017 Mar 22.
PMID: 28342823

Acute neuroinflammation provokes intracellular acidification in mouse hippocampus.
Tyrtyshnaia AA, Lysenko LV, Madamba F, Manzhulo IV, Khotimchenko MY, Kleschevnikov AM.
J Neuroinflammation. 2016 Nov 3;13(1):283.
PMID: 27809864

TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease.
Zhao X, Chen XQ, Han E, Hu Y, Paik P, Ding Z, Overman J, Lau AL, Shahmoradian SH, Chiu W, Thompson LM, Wu C, Mobley WC.
Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):E5655-64. doi: 10.1073/pnas.1603020113. Epub 2016 Sep 6.
PMID: 27601642

An Anti-ß-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome.
Belichenko PV, Madani R, Rey-Bellet L, Pihlgren M, Becker A, Plassard A, Vuillermot S, Giriens V, Nosheny RL, Kleschevnikov AM, Valletta JS, Bengtsson SK, Linke GR, Maloney MT, Hickman DT, Reis P, Granet A, Mlaki D, Lopez-Deber MP, Do L, Singhal N, Masliah E, Pearn ML, Pfeifer A, Muhs A, Mobley WC.
PLoS One. 2016 Mar 29;11(3):e0152471. doi: 10.1371/journal.pone.0152471. eCollection 2016.
PMID: 27023444

Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues.
Belichenko PV, Kleschevnikov AM, Becker A, Wagner GE, Lysenko LV, Yu YE, Mobley WC.
PLoS One. 2015 Jul 31;10(7):e0134861. doi: 10.1371/journal.pone.0134861. eCollection 2015.
PMID: 26230397

Increased cortical synaptic activation of TrkB and downstream signaling markers in a mouse model of Down Syndrome.
Nosheny RL, Belichenko PV, Busse BL, Weissmiller AM, Dang V, Das D, Fahimi A, Salehi A, Smith SJ, Mobley WC.
Neurobiol Dis. 2015 May;77:173-90. doi: 10.1016/j.nbd.2015.02.022. Epub 2015 Mar 6.
PMID: 25753471

Soluble γ-Secretase Modulators Selectively Inhibit the Production of the 42-Amino Acid Amyloid β Peptide Variant and Augment the Production of Multiple Carboxy-Truncated Amyloid β Species.
Wagner SL, Zhang C, Cheng S, Nguyen P, Zhang X, Rynearson KD, Wang R, Li Y, Sisodia SS, Mobley WC, Tanzi RE.
Biochemistry
Publish date: 2014 Jan 22. [Epub ahead of print]
PMID: 24401146

A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP.
Weissmiller AM, Natera-Naranjo O, Reyna SM, Pearn ML, Zhao X, Nguyen P, Cheng S, Goldstein LS, Tanzi RE, Wagner SL, Mobley WC, Wu C.
PLoS One. 2015 Feb 24;10(2):e0118379. doi: 10.1371/journal.pone.0118379. eCollection 2015.
PMID: 25710492

Aging and intellectual disability: insights from mouse models of Down syndrome.
Ruparelia A, Pearn ML, Mobley WC.
Dev Disabil Res Rev. 2013;18(1):43-50. doi: 10.1002/ddrr.1127. Review.
PMID: 23949828

Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome.
Wang X, Zhao Y, Zhang X, Badie H, Zhou Y, Mu Y, Loo LS, Cai L, Thompson RC, Yang B, Chen Y, Johnson PF, Wu C, Bu G, Mobley WC, Zhang D, Gage FH, Ranscht B, Zhang YW, Lipton SA, Hong W, Xu H.
Nat Med. 2013 Apr;19(4):473-80. doi: 10.1038/nm.3117. Epub 2013 Mar 24.
PMID: 23524343

Potential use of γ-secretase modulators in the treatment of Alzheimer disease.
Wagner SL, Tanzi RE, Mobley WC, Galasko D.
Arch Neurol. 2012 Oct;69(10):1255-8. Review.
PMID: 22801784

Cognitive and pharmacological insights from the Ts65Dn mouse model of Down syndrome.
Ruparelia A, Pearn ML, Mobley WC.
Curr Opin Neurobiol. 2012 Oct;22(5):880-6. doi: 10.1016/j.conb.2012.05.002. Epub 2012 May 30.
PMID: 22658745

Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome.
Kleschevnikov AM, Belichenko PV, Gall J, George L, Nosheny R, Maloney MT, Salehi A, Mobley WC.
Neurobiol Dis. 2012 Feb;45(2):683-91. doi: 10.1016/j.nbd.2011.10.009. Epub 2011 Oct 17.
PMID: 22062771

Three-dimensional synaptic ultrastructure in the dentate gyrus and hippocampal area CA3 in the Ts65Dn mouse model of Down syndrome.
Popov VI, Kleschevnikov AM, Klimenko OA, Stewart MG, Belichenko PV.
J Comp Neurol. 2011 May 1;519(7):1338-54. doi: 10.1002/cne.22573.
PMID: 21452200

Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome.
Salehi A, Faizi M, Colas D, Valletta J, Laguna J, Takimoto-Kimura R, Kleschevnikov A, Wagner SL, Aisen P, Shamloo M, Mobley WC.
Sci Transl Med. 2009 Nov 18;1(7):7ra17. doi: 10.1126/scitranslmed.3000258.
PMID: 20368182

The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome.
Belichenko NP, Belichenko PV, Kleschevnikov AM, Salehi A, Reeves RH, Mobley WC.
J Neurosci. 2009 May 6;29(18):5938-48. doi: 10.1523/JNEUROSCI.1547-09.2009.
PMID: 19420260

Widespread changes in dendritic and axonal morphology in Mecp2-mutant mouse models of Rett syndrome: evidence for disruption of neuronal networks.
Belichenko PV, Wright EE, Belichenko NP, Masliah E, Li HH, Mobley WC, Francke U.
J Comp Neurol. 2009 May 20;514(3):240-58. doi: 10.1002/cne.22009.
PMID: 19296534

Evidence for both neuronal cell autonomous and nonautonomous effects of methyl-CpG-binding protein 2 in the cerebral cortex of female mice with Mecp2 mutation.
Belichenko NP, Belichenko PV, Mobley WC.
Neurobiol Dis. 2009 Apr;34(1):71-7. doi: 10.1016/j.nbd.2008.12.016. Epub 2009 Jan 8.
PMID: 19167498

Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome.
Belichenko PV, Kleschevnikov AM, Masliah E, Wu C, Takimoto-Kimura R, Salehi A, Mobley WC.
J Comp Neurol. 2009 Feb 1;512(4):453-66. doi: 10.1002/cne.21895.
PMID: 19034952

Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships.
Belichenko PV, Kleschevnikov AM, Salehi A, Epstein CJ, Mobley WC.
J Comp Neurol. 2007 Oct 1;504(4):329-45.
PMID: 17663443

Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome.
Belichenko PV, Masliah E, Kleschevnikov AM, Villar AJ, Epstein CJ, Salehi A, Mobley WC.
J Comp Neurol. 2004 Dec 13;480(3):281-98.
PMID: 15515178

Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome.
Kleschevnikov AM, Belichenko PV, Villar AJ, Epstein CJ, Malenka RC, Mobley WC.
J Neurosci. 2004 Sep 15;24(37):8153-60.
PMID: 15371516

NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals.
Delcroix JD, Valletta JS, Wu C, Hunt SJ, Kowal AS, Mobley WC.
Neuron. 2003 Jul 3;39(1):69-84.
PMID: 12848933