Dr. John Chang studies the cellular and molecular mechanisms underlying T lymphocyte fate specification. Dr. Chang is the recipient of several awards, including the HHMI Physician-Scientist Early Career Award and the NIH Director's New Innovator Award, and is currently funded by grants from the National Institutes of Health and the Crohn's and Colitis Foundation of America. In 2016, Dr. Chang was elected to the American Society for Clinical Investigation and received the AGA-GRG Young Investigator Award in Basic Science.
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A central problem faced by multi-cellular organisms is the need for rare progenitor cells to continually produce terminally differentiated cells while also preserving a self-renewing lineage. In the mammalian immune system, T lymphocytes face a similar need for simultaneous differentiation and regeneration. The goal of our research is to understand the molecular mechanisms enabling activated T lymphocytes to give rise to differentially fated progeny.
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Lab Location University of California, San Diego Biomedical Research Facility 2 (BRF2) Room 5220L
Mailing Address University of California, San Diego 9500 Gilman Drive #0063 La Jolla, CA 92093-0063
Phone: 858-822-7568 Fax: 858-822-7652
Just published:
"Integrin activation controls regulatory T cell-mediated peripheral tolerance" Congratulations to Jane Klann!
"USP11 Enhances TGFbeta-induced Epithelial-Mesenchymal Plasticity and Human Breast Cancer Metastasis." Congratulations to Daniel Garcia!