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Extracorporeal membrane oxygenation (ECMO) is a mechanical life support for refractory respiratory and/or cardiac failure. Our research evaluates biomarker's changes associated with clinical interventions (ventilator changes, prone positioning, etc) for patients on ECMO. Quality improvement ECMO projects include evaluating nurses as the ECMO bedside specialist, physical therapy for severe ARDS patients on ECMO, and anticoagulation.