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Publications

Original Research 

Kreitinger KY, Lui MMS, Owens RL, Schmickl CN, Grunvald E, Horgan S, Raphelson JR, Malhotra A. Screening for Obstructive Sleep Apnea in a Diverse Bariatric Surgery Population. Obesity (Silver Spring). 2020 Nov;28(11):2028-2034. doi: 10.1002/oby.23021. PMID: 33150742.

Malhotra A, Mesarwi O, Pepin J, Owens RL. Endotypes and phenotypes in obstructuve sleep apnea. Curr Opin Pulm Med. 2020 Nov;26(6)609-614. doi: 10.1097/MCP.0000000000000724. PMID: 32890019. 

Wardi G, Joel I, Villar J, Lava M, Gross E, Tolia V, Seethala RR, Owens RL, Sell Re, Montesi SB, Rahaghi FN, Bose S, Rai A, Stevenson EK, McSparron J, Tolia V, Beitler JR. Equipose in Appropriate Initial Volume Resuscitation for Patients in Septic Shock with Heart Failure: Results of a Multicenter Clinician Survey. J Investive Care Med. 2020 Nov;35(11):1338-1345. doi: 10.1177/0885066619871247. PMID: 31446829. 

Jaiswal SJ, Kang DY, Wineinger NE, Owens RL. Objectively measured sleep fragmentation is associated with incident delirium in older hospitalized patients: Analysis of data collected from an randomized controlled trial. J Sleep Res. 2020 Oct 13;e13205. doi: 10.10111/jsr.13205. [Online ahead of print] PMID: 33051948. 

Park JH, Derry KL, Owens RL. Dexmedetomidine as add-on sedation to reduce continuous infusion sedative in mechanically ventilated patients. Am J Health Syst Pharm. 2020 Oct 10;zxaa327. doi: 10.1093/ajhp/zxaa327. [Online ahead of print] PMID: 33038212.

Boehm LM, Pun BT, Stollings JL, Girard TD, Rock P, Hough CL, Hsieh SJ, Khan BA, Owens RL, Schmidt GA, Smith S, Ely EW. A multisite study of nurse-reported perceptions and practice of ABCDEF bundle components. Intensive Crit Care Nurs. 2020 Oct;60:102872. doi: 10.1016/j.iccn.2020.102872. PMID: 32389395. 

Bellinghausen AL, LaBuzetta JN, Chu F, Novelli F, Rodela AR, Owens RLLessons from an ICU recovery clinic: two cases of meralgia paresthetica after prone positioning to treat COVID-19 associated ARDS and modification of unit practices. Crit Care. 2020 Sep 27;24(1):580. doi: 10.1186/s13054-020-03289-4. PMID: 32981525. 

Khandwalla RM, Grant D, Birkeland K, Heywood JT, Fombu E, Owens RL, Steinhubl SR, AWAKE-H. F. Study Investigators. The AWAKE-HF Study: Sacubitril/Valsartan Impact on Daily Physical Activity and Sleep in Heart Failure. Am J Cardiovasc Drugs. 2020 Sep 26. doi: 10.1007/s40256-020-00440-y. [Online ahead of print]. PMID: 32978755. 

Jaiswal SJ, Quer G, Galarnyk M, Steinhubl SR, Topol EJ, Owens RL. Association of Sleep Duration and Variability With Body Mass Index: Sleep Measurements in a Large US Population of Wearable Sensor Users. JAMA Intern Med. 2020 Sep 14;e202834. doi: 10.1001/jamainternmed.2020.2834. [Online ahead of print] PMID: 32926073. 

Colvonen PJ, DeYoung PN, Bosompra NA, Owens RL. Limiting racial disparities and bias for wearable devices in health science research. Sleep. 2020 Sep 7;zsaa159. doi:10.1093/sleep/zsaa159. [Online ahead of print] PMID: 32893865. 

Macrea M, Ockowski S, Rochwerg B, Branson RD, Celli B, Coleman JM, Hess DR, Knight SL, Ohar JA, Orr JE, Piper AJ, Punjabi NM, Rahangdale S, Wijkstra PJ, Yim-Yeh S, Drummond MB, Owens RL. Long-Term Noninvasive Ventilation in Chronic Stable Hypercapnic Chronic Obstructive Pulmonary Disease. An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med. 2020 Aug 15;202(4):e74-e87. doi: 10.1164/rccm.202006-2382ST. PMID: 32795139. 

Schmickl CN, Li Y, Orr JE, Jen R, Sands SA, Edwards BA, DeYoung P, Owens RL, Malhotra A. Effect of Venlafaxine on Apnea-Hypopnea Index in Patients with Sleep Apnea: A Randomized, Double-Blind Crossover Study. Chest. 2020 Aug;158(2):765-775. doi: 10.1016/j.chest.2020.02.074. PMID: 32278781. 

Schmickl CN, Lettieri CJ, Orr JE, DeYoung P, Edwards BA, Owens RL, Malhotra A. The Arousal Threshold as a Drug-Target to Improve CPAP Adherence: Secondary Analysis of a Randomized Trial. Am J Respir Crit Care Med. 2020 Jul 16. doi: 10.1164/rccm.202003-0502LE. [Online ahead of print] PMID: 32673496.

Odish MF, Bellinghausen A, Golts E, Owens RL. E-cigarette, or vaping, product use-associated lung injury (EVALI) treated with veno-venous extracorporeal membrane oxygenation (VV-ECMO) and ultra-protective ventilator settings. BMJ Case Rep. 2020 Jul 2;13(7):e234771. doi: 10.1136/bcr-2020-234771. PMID: 32616535. 

Owens RL, Campana LM, Foster AM, Schomer AM, Israel E, Malhotra A. Nocturnal bilevel positive airway pressure for the treatment of asthma. Respir Physiol Neurobiol. 2020 Mar;274:103355. doi: 10.1016/j.resp.2019.103355. PMID: 31805396. 

Orr JE, Schmickl CN, Edwards BA, DeYoung P, Brena R, Sun XS, Jain S, Malhotra A, Owens RL. Pathogenesis of obstructive sleep apnea in individuals with the CPOD+OSA Overlap syndrome versus OSA alone. Physiol Rep. 2020 Feb;8(3):e14371. doi: 10.14814/phy2.14371. PMID: 32061184. 

Jen R, Orr JE, Li Y, DeYoung P, Smales E, Malhotra A, Owens RL. Accuracy of WatchPAT for the Diagnosis of Obstructive Sleep Apnea in Patients with Chronic Obstructive Pulmonary Disease. COPD. 2020 Feb;17(1):34-39. doi: 10.1080/15412555.2019.1707789. PMID: 31965862.

Jaiswal SJ, Vyas AD, Heisel AJ, Ackula H, Aggarwal A, Kim NH, Kerr KM, Madani M, Pretorius V, Auger W, Fernandes T, Malhotra A, Owens RL. Ramelteon for Prevention of Postoperative Delirium: A Randomized Controlled Trial in Patients Undergoing Elective Pulmonary Thromboendarterectomy. Crit Care Med. 2019 Dec;47(12):1751-1758. doi: 10.1097/CCM.0000000000004004. PMID: 31567351. 

Khandwalla RM, Birkeland K, Heywood JT, Steinhubl S, McCague K, Fombu E, Grant D, Riebman JB, Owens RL. Activity Sensors to Evaluate the Effect of Sacubitril/Valsartan on Quality-of-Life in Heart Failure: rational and design of the AWAKE-HF study. ESC Heart Fail. 2019 Dec;6(6):1313-1321. doi: 10.1002/ehf2.12514. PMID: 31638338. 

Macrea MM, Owens RL, Martin T, Smith D, Oursler KA, Malhotra A. The effect of isolated nocturnal oxygen desaturations on serum hs-CRP and IL-6 in patients with chronic obstructive pulmonary disease. Clin Respir J. 2019 Aug 1;13(2):120-124. doi: 10.1111/crj.12992. PMID: 30638307.


Li Y, Ye J, Han D, Zhao D, Cao X, Orr J, Jen R, Deacon-Diaz N, Sands SA, Owens R, Malhotra A.  The Effect of Upper Airway Surgery on Loop Gain in Obstructive Sleep Apnea.  J Clin Sleep Med. 2019 Jun 15;15(6):907-913. doi: 10.5664/jcsm.7848. PMID: 31138381

Ye L, Owens RL, Dykes P.  Individualized sleep promotion in acute care hospitals: Identifying factors that affect patient sleep.  Appl Nurs Res. 2019 Aug;48:63-67. Epub 2019 May 11.  PMID: 31266610

Orr JE, Coleman J, Criner GJ, Sundar KM, Tsai SC, Benjafield AV, Crocker ME, Willes L, Malhotra A, Owens RL, Wolfe LF.  Automatic EPAP intelligent volume-assured pressure support is effective in patients with chronic respiratory failure: A randomized trial.  Respirology. 2019 Apr 22. doi: 10.1111/resp.13546. [Epub ahead of print] PMID: 31012225

Huynh TG, Owens RL, Davidson JE.  Impact of Built Design on Nighttime Family Presence in the Intensive Care Unit.  HERD. 2019 Apr 2 [Epub ahead of print]  PMID: 30939938.

Li Y, Orr J, Jen R, Sands SA, DeYoung P, Smales E, Edwards B, Owens RL, Malhotra A.  Is there a Threshold that Triggers Cortical Arousals in Obstructive Sleep Apnea.  Sleep. 2019 Feb 22. pii: zsz047. doi: 10.1093/sleep/zsz047. [Epub ahead of print]. PMID: 30794310

Meier A, Yang J, Liu J, Beitler JR, Tu XM, Owens RL, Sundararajan RL, Malhotra A, Sell RE.  Female Physician Leadership During Cardiopulmonary Resuscitation Is Associated With Improved Patient Outcomes.  Crit Care Med. 2019 Jan;47(1):e8-e13. PMID: 30303843.

Girard TD, Exline MC, Carson SS, Hough CL, Rock P, Gong MN, Douglas IS, Malhotra A, Owens RL, Feinstein DJ, Khan B, Pisani MA, Hyzy RC, Schmidt GA, Schweickert WD, Hite RD, Bowton DL, Masica AL, Thompson JL, Chandrasekhar R, Pun BT, Strength C, Boehm LM, Jackson JC, Pandharipande PP, Brummel NE, Hughes CG, Patel MB, Stollings JL, Bernard GR, Dittus RS, Ely EW; MIND-USA Investigators.  Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness.  N Engl J Med. 2018 Dec 27;379(26):2506-2516. PMID: 30346242.

Sands SA, Edwards BA, Terrill PI, Butler JP, Owens RL, Taranto-Montemurro L, Azarbarzin A, Marques M, Hess LB, Smales ET, de Melo CM, White DP, Malhotra A, Wellman A.  Identifying obstructive sleep apnoea patients responsive to supplemental oxygen therapy.  Eur Respir J. 2018 Sep 27;52(3). PMID: 30139771.  

Hudgel DW, Patel SR, Ahasic AM, Bartlett SJ, Bessesen DH, Coaker MA, Fiander PM, Grunstein RR, Gurubhagavatula I, Kapur VK, Lettieri CJ, Naughton MT, Owens RL, Pepin JD, Tuomilehto H, Wilson KC; American Thoracic Society Assembly on Sleep and Respiratory Neurobiology.  The Role of Weight Management in the Treatment of Adult Obstructive Sleep Apnea. An Official American Thoracic Society Clinical Practice Guideline.  Am J Respir Crit Care Med. 2018 Sep 15;198(6):e70-e87. PMID: 30215551

Jaiswal SJ, McCarthy TJ, Wineinger NE, Kang DY, Song J, Garcia S, van Niekerk CJ, Lu CY, Loeks M, Owens RLMelatonin and Sleep in Preventing Hospitalized Delirium: A Randomized Clinical Trial. Am J Med. 2018 Sep;131(9):1110-1117. PMID: 29729237

Light M, Orr JE, Malhotra A, Owens RL. Continuous positive airway pressure device detects atrial fibrillation induced central sleep apnoea. Lancet. 2018 Jul 14;392(10142):160. doi: 10.1016/S0140-6736(18)31381-3. No abstract available. PMID: 30017134

Orr JE, Sands SA, Edwards BA, Deyoung PN, Deacon N, Jen R, Li Y, Owens RL, Malhotra A. Measuring Loop Gain via Home Sleep Testing in Patients with Obstructive Sleep Apnea. Am J Respir Crit Care Med. 2018 May 15;197(10):1353-1355. PMID: 29190428

Jaiswal SJ, McCarthy TJ, Wineinger NE, Kang DY, Song J, Garcia S, van Niekerk CJ, Lu CY, Loeks M, Owens RL. Melatonin and Sleep in Preventing Hospitalized Delirium: A Randomized Clinical Trial.  Am J Med. 2018 May 3. pii: S0002-9343(18)30386-3. doi: 10.1016/j.amjmed.2018.04.009. [Epub ahead of print]  PMID: 29729237

Bakker JP, Tavakkoli A, Rueschman M, Wang W, Andrews R, Malhotra A, Owens RL, Anand A, Dudley KA, Patel SR. Gastric Banding Surgery versus Continuous Positive Airway Pressure for Obstructive Sleep Apnea: A Randomized Controlled Trial. Am J Respir Crit Care Med. 2018 Apr 15;197(8):1080-1083. PMID: 29035093

Tainter CR, Nguyen AP, Pollock KA, O'Brien EO, Lee J, Schmidt U, Jahanasouz F, Owens RL, Meier A. The impact of a daily "medication time out" in the Intensive Care Unit. J Crit Care. 2018 Feb;43:366-369. doi: 10.1016/j.jcrc.2017.09.018. PMID: 28939276

Jaiswal SJ, Garcia S, Owens RL.  Sound and Light Levels Are Similarly Disruptive in ICU and non-ICU Wards.  J Hosp Med. 2017 Oct;12(10):798-804. PMID: 28991944

Li Y, Ye J, Han D, Cao X, Ding X, Zhang Y, Xu W, Orr J, Jen R, Sands S, Malhotra A, Owens R.  Physiology-Based Modeling May Predict Surgical Treatment Outcome for Obstructive Sleep Apnea.  J Clin Sleep Med. 2017 Sep 15;13(9):1029-1037. PMID: 28818154
*With accompanying editorial

Kang DY, DeYoung PN, Malhotra A, Owens RL, Coleman TP.  A State Space and Density Estimation Framework for Sleep Staging in Obstructive Sleep Apnea.  IEEE Trans Biomed Eng. 2017 May 8. [Epub ahead of print] PMID: 28499990.

Reviews and Editorials

Owens RL. Still just the tip of the iceberg. J Clin Sleep Med. 2020 Oct 15. doi: 10.5664/jcsm.8876. [Online ahead of print]. PMID: 33054966. 

Orr JE, Owens RL. Chronic Obstructive Pulmonary Disease and Breathing during Sleep. A Strain in the Neck. Am J Respir Crit Care Med. 2020 Feb 15;201(4):395-396. doi: 10.1164/rccm.201911-2174ED. PMID: 31810375. 

Schmickl CN, Landry SAOrr JE, Chin K, Murase K, Verbraecken J, Javaheri S, Edwards BA, Owens RL, Malhotra A. Acetazolamide for OSA and Central Sleep Apnea: A Comprehensive Systematic Review and Meta-Analysis. Chest. 2020 Aug 5;S0012-2692(20)31904-8. doi: 10.1016/j.chest.2020.06.078. PMID: 32768459. 

Chang VA, Owens RL, LaBuzetta JN. Impact of Sleep Deprivation in the Neurological Intensive Care Unit: A Narrative Review. Neurocrit Care. 2020 Apr;32(2):596-608. doi: 10.1007/s12028-019-00795-4. PMID: 31410770. 

Schmickl CN, Owens RLOrr JE, Edwards BA, Malhotra A. Side effects of acetazolamide: a systematic review and meta-analysis in assessing overall risk and dose dependence. BMJ Open Respir Res. 2020 Apr;7(1):e000557. doi: 10.1136/bmjresp-2020-000557. PMID: 32332024. 

Sunwoo BY, Owens RL. All that wheezes at night is not asthma. Respirology. 2019 Dec;24(12):1127-1128. doi: 10.1111/resp.13622. PMID: 31195427. 

Dorsch JJ, Martin JL, Malhotra A, Owens RL, Kamdar BB. Sleep in the Intensive Care Unit: Strategies for Improvement. Semin Respir Crit Care Med. 2019 Oct;40(5):614-628. doi: 10.1055/s-0039-1698378. PMID: 31826262.

Light MOwens RLSchmickl CN, Malhotra A. Precision Medicine for Obstructive Sleep Apnea. Sleep Med Clin. 2019 Sep;14(3):391-398. doi: 10.1016/j.jsmc.2019.05.005. PMID: 31375207.

Vitale KC, Owens R, Hopkins SR, Malhotra A.  Sleep Hygiene for Optimizing Recovery in Athletes: Review and Recommendations.  Int J Sports Med. 2019 Aug;40(8):535-543.  PMID: 31288293

Edwards BA, Redline S, Sands SA, Owens RLMore than the Sum of the Respiratory Events: Personalized Medicine Approaches for Obstructive Sleep Apnea.  Am J Respir Crit Care Med. 2019 Apr 25. [Epub ahead of print]  PMID: 31022356

Owens RL, Hicks CB. A Wake-up Call for Human Immunodeficiency Virus (HIV) Providers: Obstructive Sleep Apnea in People Living With HIV. Clin Infect Dis. 2018 Jul 18;67(3):472-476. PMID: 29746617

Orr JE, DeYoung PN, Owens RLThe Future of the Sleep Lab: It's Complicated.  J Clin Sleep Med. 2018 Apr 15;14(4):499-500. PMID: 29609726

Putman RK, Owens RL. Can a Floppy Upper Airway Lead to Stiff Lungs?  Ann Am Thorac Soc. 2017 Dec;14(12):1759-1760. PMID: 29192817

Owens RL, Macrea MM, Teodorescu M.  The overlaps of asthma or COPD with OSA: A focused review.  Respirology. 2017 Aug;22(6):1073-1083. PMID: 28677827

Owens RL, Huynh TG, Netzer G.  Sleep in the Intensive Care Unit in a Model of Family-Centered Care.  AACN Adv Crit Care. 2017 Summer;28(2):171-178. PMID: 28592477

Laghi F, Owens RL. COPD+OSA: can two bad things be good for you? Thorax. 2016 Dec 23. [Epub ahead of print] PMID: 28011858

Owens RL. Better Sleep in the Intensive Care Unit: Blue Pill or Red Pill… or No Pill? Anesthesiology. 2016 Nov;125(5):835-837. PMID: 27571258

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