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Is Obsctruictive Sleep Apnea Important in the Development of Alzheimer's Disease?

If you wish to participate or have questions about this study, please contact us at, or (858)246-2154. Alternatively, you may fill out our volunteer survey form so our research staff members can reach out to you. 

​Our research team at UC San Diego is conducting a study to examine how Obstructive Sleep Apnea (OSA) may contribute to the potential risk of Alzheimer's disease. Participation in this study may or may not benefit you directly and may result in new knowledge that may help others.

Principal Investigator:

Atul Malhotra, MD 

Maximum compensation for completing entire study (performed over 16-18 weeks):



  • Age 65-85 years
  • Independently living and able to drive 
  • OSA (AHI ≥ 15/h) or no OSA 

What you may be asked to do during this study:

  • Rapid COVID Tests
  • 2 in-clinic daytime visits for medical history, physical exam, and neurocognitive assessments.
  • 3 in-clinic overnight visit to assess OSA presence and severity
  • Two of these visits will require breathing either regular air (room air) or supplemental oxygen while you              sleep.
  • 1 visits in Sorrento Valley for an MRI and PET scan of the head duirng the day or evening (not overnght)
  • A 3-month trial to either treat your sleep apnea (positive airway pressure therapy) or use therapeutic nightly                   oxygen.
  • Non-invasive measures of blood vessel function
  • Computerized reaction-time tests
  • Study questionnaires 
  • Blood draws
  • For more detailed information, please read this study's Consent Documents.