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Underlying Mechanisms of Obesity-induced Obstructive Sleep Apnea (SLIM-OSA)

If you wish to participate or have questions about this study, please contact us at, or (858)246-2154. Alternatively, you may fill out our volunteer survey form so our research staff members can reach out to you. 

​Our research team at UC San Diego is conducting a study to gain major insights into the unanswered question "why does obesity (sometimes) cause sleep apnea". This research will have major therapeutic implications as it will allow the investigators to individualize therapy for afflicted patients. 

Principal Investigator and Collaborator:

Atul Malhotra, MD and Brandon Nokes, Post-doctoral fellow

Maximum compensation for completing entire study (exercises done over 6 weeks):



  • Age 30-65 years
  • BMI 35-40 kg/m2
  • Scheduled for sleeve gastrectomy (bariatric surgery)

What you may be asked to do during this study:

  • 5 in-clinic overnight visits to assess any changes in OSA presence and severity
  • 2 visits in Sorrento Valley for an MRI of the head and upper airway duirng the day or evening (not overnght)
  • Non-invasive measures of blood vessel function
  • Lung function assessments
  • Computerized reaction-time tests
  • Study questionnaires 
  • Blood draws
  • For more detailed information, please read this study's Consent Documents  or visit

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