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The Impact of Sleep Disordered Breathing in People who use Opioids (Aim 1)

If you wish to participate or have questions about this study, please contact us at, or (858)246-2154. Alternatively, you may fill out our volunteer survey form so our research staff members can reach out to you. 

​Our research team at UC San Diego is conducting a study to investigate whether Positive Airway Pressure (PAP) therapy may help relieve unstable breathing and determine if the treatment has a positive effect on sleep and pain perception in people who use opioids on a daily basis.

Principal Investigator and Collaborator:

Jeremy Orr, MD

Maximum compensation for completing entire study:



  • Age +18 years
  • Chronic Pain
  • Chronic opioid use (daily use for >3 months duration)
  • Apnea-hypopnea index >/= 5 events/hr

What you may be asked to do during this study:

  • 1 in-clinic Overnight visit to assess OSA presence and severity (10-12 hours)
  • 1 in-clinic Daytime visit (30-45 minutes)
  • 1 in-clinic Evening Visit (1-2 hours)
  • Cold water hand bath
  • Computerized reaction-time tests
  • Study questionnaires 
  • Wrist-worn activity tracker
  • Blood draws
  • For more detailed information, please read this study's Consent Documents  or visit

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