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Selected Publications from the UCSD Sleep Research Laboratory

For all publications from any of the Sleep Research faculty, click on their name on the People page to be taken to their UCSD Profile.


  1. Darquenne C, Elliott AR, Sibille B, Smales ET, DeYoung PN, Theilmann RJ, and Malhotra A. Upper airway dynamic imaging during tidal breathing in awake and asleep subjects with obstructive sleep apnea and healthy controls. Physiological Reports. 2018, In Press.


  1. Orr JE, Sands SA, Edwards BA, Deyoung PN, Deacon N, Jen R, Li Y, Owens RL, Malhotra A. Measuring Loop Gain via Home Sleep Testing in Patients with Obstructive Sleep Apnea. Am J Respir Crit Care Med. 2017 Nov 30. PMID: 29190428
  2. Kang DY, DeYoung PN, Malhotra A, Owens RL, Coleman TP. A State Space and Density Estimation Framework for Sleep Staging in Obstructive Sleep Apnea. IEEE Trans. Biomed. Eng. 2017 May 8. 
  3. Landry SA, Joosten SA, Sands SA, White DP, Malhotra A, Wellman A, Hamilton GS, Edwards BA. Response to a combination of oxygen and a hypnotic as treatment for obstructive sleep apnoea is predicted by a patient's therapeutic CPAP requirement.Respirology. 2017 Apr 13. PMID: 28409851.
  4. Hicks A, Cori JM, Jordan AS, Nicholas CL, Kubin L, Semmler JG, Malhotra A, McSharry DG, Trinder JA. Mechanisms of the deep slow-wave-sleep-related increase of upper airway muscle tone in healthy humans. J Appl Physiol (1985). 2017 Mar 02. PMID: 28255086.
  5. Orr JE, Smales C, Alexander TH, Stepnowsky C, Pillar G, Malhotra A, Sarmiento KF. Treatment of OSA with CPAP is Associated with Improvement in PTSD Symptoms among Veterans. J Clin Sleep Med. 2017 Jan 15;13(1):57-63. PMID: 27707436.


  1. Edwards BA, Andara C, Landry S, Sands SA, Joosten SA, Owens RL, White DP, Hamilton GS, Wellman A. Upper-Airway Collapsibility and Loop Gain Predict the Response to Oral Appliance Therapy in Patients with Obstructive Sleep Apnea. Am J Respir Crit Care Med. 2016 Dec 1;194(11):1413-1422. PMID: 27181367
  2. Li Y, Owens RL, Sands S, Orr J, Moraes W, DeYoung P, Smales E, Jen R, Malhotra A. The Effect of Donepezil on Arousal Threshold and Apnea-Hypopnea Index. A Randomized, Double-Blind, Cross-Over Study. Ann Am Thorac Soc. 2016 Nov; 13(11):2012-2018. PMID: 27442715.
  3. Edwards BA, Sands SA, Owens RL, Eckert DJ, Landry S, White DP, Malhotra A, Wellman A. The Combination of Supplemental Oxygen and a Hypnotic Markedly Improves Obstructive Sleep Apnea in Patients with a Mild to Moderate Upper Airway Collapsibility. Sleep. 2016 Nov 1; 39(11):1973-1983. PMID: 27634790.
  4. Jaiswal SJ, Malhotra A, Owens RL. Sleep and critical illness: bridging the two pillars at the ATS 2016. J Thorac Dis. 2016 Jul; 8(Suppl 7):S536-8. PMID: 27606086.
  5. Li Y, Deacon N, Jen R, Owens R. Non positive airway pressure therapies for sleep disordered breathing from the ATS 2016. J Thorac Dis. 2016 Jul; 8(Suppl 7):S547-9. PMID: 27606090.
  6. Orr JE, Auger WR, DeYoung PN, Kim NH, Malhotra A, Owens R. Usefulness of Low Cardiac Index to Predict Sleep-Disordered Breathing in Chronic Thromboembolic Pulmonary Hypertension. Am J Cardiol. 2016 Mar 15; 117(6):1001-5. PMID: 26805659.
  7. Bhattacharjee R, Kheirandish-Gozal L, Kaditis AG, Verhulst SL, Gozal D. C-reactive Protein as a Potential Biomarker of Residual Obstructive Sleep Apnea Following Adenotonsillectomy in ChildrenSleep. 2016 Feb 1;39(2):283-91. PMID: 26414898.
  8. Deacon NL, Jen R, Li Y, Malhotra A. Treatment of Obstructive Sleep Apnea. Prospects for Personalized Combined Modality Therapy. Ann Am Thorac Soc. 2016 Jan; 13(1):101-8. PMID: 26569377.

2015 and earlier

  1. Soler X, Gaio E, Powell FL, Ramsdell JW, Loredo JS, Malhotra A, Ries AL. High Prevalence of Obstructive Sleep Apnea in Patients with Moderate to Severe Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc. 2015 Aug; 12(8):1219-25. PMID: 25871443.
  2. Smales ET, Edwards BA, Deyoung PN, McSharry DG, Wellman A, Velasquez A, Owens R, Orr JE, Malhotra A. Trazodone Effects on Obstructive Sleep Apnea and Non-REM Arousal Threshold. Ann Am Thorac Soc. 2015 May; 12(5):758-64. PMID: 25719754.
  3. Soler X, Diaz-Piedra C, Ries AL. Pulmonary rehabilitation improves sleep quality in chronic lung disease. COPD. 2013 Apr; 10(2):156-63. PMID: 23514215.