The Center

The Center for Asthma and Sinus Disease at the University of California San Diego embodies the evolution of a long history of excellence in clinical care and investigative inquiries spanning the spectrum from basic mechanisms to clinical trials. The Center was formed in 2018 to provide an overarching superstructure to integrate clinical and research efforts in asthma and upper airway disease. The Center builds upon the progress achieved through multiple pre-existing collaborations that have formed a successful network bridging expertise in medical, surgical and research disciplines. The Center represents a partnership between:

• The Division of Rheumatology, Allergy, and Immunology (Department of Medicine)
• The Division of Pulmonary, Critical Care, and Sleep Medicine (Department of Medicine)
• The Department of Otolaryngology
• The La Jolla Institute for Immunology
Retrieving Data

The formation of the UCSD Center from disparate stakeholders (many of whom have made significant contributions to asthma research and clinical care over many years) has already paid dividends in the successful application for UCSD to be part of the prestigious National, Heart, and Blood Institutes PrecISE Network (Precision Interventions in Severe and/or Exacerbation Prone Asthma Network). The PrecISE Network is tasked with bringing an adaptive, biomarker-driven Master Protocol design to the study of multiple Phase II interventions in severe asthma. This strategy has gained an increasing foothold in cancer trials, but the PrecISE
network represents the first attempt to use this strategy in a large scale in respiratory disease.
Dr. Akuthota is the lead principal investigator for the NIH UG1 award that supports the UCSD
Centers participation in the network. Dr. Vijayanand from the La Jolla Institute for Immunology is a co-PI, as is biostatistician Dr. Sonia Jain. The UCSD investigators are integral members of the
PrecISE Steering Committee and participate in (and in some cases lead) several key